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Meandering nanochannels for imaging of ultra-long DNA molecules

Freitag, C. ; Fritzsche, J. ; Persson, F. LU ; Mir, Kalim U. and Tegenfeldt, J. O. LU orcid (2011) 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 3. p.1758-1760
Abstract

A new chip design for handling and studying chromosomal DNA is described. Folding the nanochannels enables us to image an entire yeast chromosome in a single field of view. Together with existing mapping techniques our new design opens up the possibility of directly analyzing entire chromosomes in a single field of view using fluorescence microscopy. This would enable, for example, identification of microorganisms on a single-cell basis and the complete physical mapping of the human genome, chromosome by chromosome.

Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Chromosomal DNA, DNA analysis, Genomics, Nanofluidics
host publication
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
volume
3
pages
3 pages
conference name
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
conference location
Seattle, WA, United States
conference dates
2011-10-02 - 2011-10-06
external identifiers
  • scopus:84883809915
ISBN
9781618395955
language
English
LU publication?
yes
id
16a122b6-54b5-4dc9-9acf-6a3f6fc5bfd2
date added to LUP
2018-10-20 08:56:19
date last changed
2021-02-17 05:33:15
@inproceedings{16a122b6-54b5-4dc9-9acf-6a3f6fc5bfd2,
  abstract     = {<p>A new chip design for handling and studying chromosomal DNA is described. Folding the nanochannels enables us to image an entire yeast chromosome in a single field of view. Together with existing mapping techniques our new design opens up the possibility of directly analyzing entire chromosomes in a single field of view using fluorescence microscopy. This would enable, for example, identification of microorganisms on a single-cell basis and the complete physical mapping of the human genome, chromosome by chromosome.</p>},
  author       = {Freitag, C. and Fritzsche, J. and Persson, F. and Mir, Kalim U. and Tegenfeldt, J. O.},
  booktitle    = {15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011},
  isbn         = {9781618395955},
  language     = {eng},
  month        = {12},
  pages        = {1758--1760},
  title        = {Meandering nanochannels for imaging of ultra-long DNA molecules},
  volume       = {3},
  year         = {2011},
}