Meandering nanochannels for imaging of ultra-long DNA molecules
Freitag, C. ; Fritzsche, J. ; Persson, F. LU ; Mir, Kalim U. and Tegenfeldt, J. O. LU
(2011)
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
3.
p.1758-1760
- Abstract
A new chip design for handling and studying chromosomal DNA is described. Folding the nanochannels enables us to image an entire yeast chromosome in a single field of view. Together with existing mapping techniques our new design opens up the possibility of directly analyzing entire chromosomes in a single field of view using fluorescence microscopy. This would enable, for example, identification of microorganisms on a single-cell basis and the complete physical mapping of the human genome, chromosome by chromosome.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/16a122b6-54b5-4dc9-9acf-6a3f6fc5bfd2
- author
- Freitag, C.
; Fritzsche, J.
; Persson, F.
LU
; Mir, Kalim U.
and Tegenfeldt, J. O.
LU
- organization
- publishing date
- 2011-12-01
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Chromosomal DNA, DNA analysis, Genomics, Nanofluidics
- host publication
- 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
- volume
- 3
- pages
- 3 pages
- conference name
- 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
- conference location
- Seattle, WA, United States
- conference dates
- 2011-10-02 - 2011-10-06
- external identifiers
-
- scopus:84883809915
- ISBN
- 9781618395955
- language
- English
- LU publication?
- yes
- id
- 16a122b6-54b5-4dc9-9acf-6a3f6fc5bfd2
- date added to LUP
- 2018-10-20 08:56:19
- date last changed
- 2023-10-20 13:24:57
@inproceedings{16a122b6-54b5-4dc9-9acf-6a3f6fc5bfd2,
abstract = {{<p>A new chip design for handling and studying chromosomal DNA is described. Folding the nanochannels enables us to image an entire yeast chromosome in a single field of view. Together with existing mapping techniques our new design opens up the possibility of directly analyzing entire chromosomes in a single field of view using fluorescence microscopy. This would enable, for example, identification of microorganisms on a single-cell basis and the complete physical mapping of the human genome, chromosome by chromosome.</p>}},
author = {{Freitag, C. and Fritzsche, J. and Persson, F. and Mir, Kalim U. and Tegenfeldt, J. O.}},
booktitle = {{15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011}},
isbn = {{9781618395955}},
keywords = {{Chromosomal DNA; DNA analysis; Genomics; Nanofluidics}},
language = {{eng}},
month = {{12}},
pages = {{1758--1760}},
title = {{Meandering nanochannels for imaging of ultra-long DNA molecules}},
volume = {{3}},
year = {{2011}},
}