Blood biomarkers for Alzheimer’s disease in clinical practice and trials
Hansson, Oskar LU
; Blennow, Kaj
LU
; Zetterberg, Henrik
LU
and Dage, Jeffrey
(2023)
In Nature Aging
3(5).
p.506-519
- Abstract
Blood-based biomarkers hold great promise to revolutionize the diagnostic and prognostic work-up of Alzheimer’s disease (AD) in clinical practice. This is very timely, considering the recent development of anti-amyloid-β (Aβ) immunotherapies. Several assays for measuring phosphorylated tau (p-tau) in plasma exhibit high diagnostic accuracy in distinguishing AD from all other neurodegenerative diseases in patients with cognitive impairment. Prognostic models based on plasma p-tau levels can also predict future development of AD dementia in patients with mild cognitive complaints. The use of such high-performing plasma p-tau assays in the clinical practice of specialist memory clinics would reduce the need for more costly investigations... (More)
Blood-based biomarkers hold great promise to revolutionize the diagnostic and prognostic work-up of Alzheimer’s disease (AD) in clinical practice. This is very timely, considering the recent development of anti-amyloid-β (Aβ) immunotherapies. Several assays for measuring phosphorylated tau (p-tau) in plasma exhibit high diagnostic accuracy in distinguishing AD from all other neurodegenerative diseases in patients with cognitive impairment. Prognostic models based on plasma p-tau levels can also predict future development of AD dementia in patients with mild cognitive complaints. The use of such high-performing plasma p-tau assays in the clinical practice of specialist memory clinics would reduce the need for more costly investigations involving cerebrospinal fluid samples or positron emission tomography. Indeed, blood-based biomarkers already facilitate identification of individuals with pre-symptomatic AD in the context of clinical trials. Longitudinal measurements of such biomarkers will also improve the detection of relevant disease-modifying effects of new drugs or lifestyle interventions.
(Less)
- author
- Hansson, Oskar
LU
; Blennow, Kaj
LU
; Zetterberg, Henrik
LU
and Dage, Jeffrey
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Aging
- volume
- 3
- issue
- 5
- pages
- 14 pages
- publisher
- Springer
- external identifiers
-
- pmid:37202517
- scopus:85160094360
- DOI
- 10.1038/s43587-023-00403-3
- language
- English
- LU publication?
- yes
- id
- 16a5844f-6ea2-46a3-9bb0-c11dc3898640
- date added to LUP
- 2023-08-22 14:02:14
- date last changed
- 2024-04-20 02:18:11
@article{16a5844f-6ea2-46a3-9bb0-c11dc3898640,
abstract = {{<p>Blood-based biomarkers hold great promise to revolutionize the diagnostic and prognostic work-up of Alzheimer’s disease (AD) in clinical practice. This is very timely, considering the recent development of anti-amyloid-β (Aβ) immunotherapies. Several assays for measuring phosphorylated tau (p-tau) in plasma exhibit high diagnostic accuracy in distinguishing AD from all other neurodegenerative diseases in patients with cognitive impairment. Prognostic models based on plasma p-tau levels can also predict future development of AD dementia in patients with mild cognitive complaints. The use of such high-performing plasma p-tau assays in the clinical practice of specialist memory clinics would reduce the need for more costly investigations involving cerebrospinal fluid samples or positron emission tomography. Indeed, blood-based biomarkers already facilitate identification of individuals with pre-symptomatic AD in the context of clinical trials. Longitudinal measurements of such biomarkers will also improve the detection of relevant disease-modifying effects of new drugs or lifestyle interventions.</p>}},
author = {{Hansson, Oskar and Blennow, Kaj and Zetterberg, Henrik and Dage, Jeffrey}},
language = {{eng}},
number = {{5}},
pages = {{506--519}},
publisher = {{Springer}},
series = {{Nature Aging}},
title = {{Blood biomarkers for Alzheimer’s disease in clinical practice and trials}},
url = {{http://dx.doi.org/10.1038/s43587-023-00403-3}},
doi = {{10.1038/s43587-023-00403-3}},
volume = {{3}},
year = {{2023}},
}