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Methylchloroisothiazolinone and/or Methylisothiazolinone Contact Allergies in Thailand

Sukakul, Thanisorn LU orcid ; Limphoka, Pichaya and Boonchai, Waranya (2021) In Dermatitis : contact, atopic, occupational, drug 32(6). p.375-380
Abstract

BACKGROUND: Methylchloroisothiazolinone, in combination with methylisothiazolinone (MCI/MI), and MI alone are common preservatives. The incidences of MCI/MI and MI-alone contact allergies have risen markedly worldwide, leading to changes in their use in products.

OBJECTIVES: The aim of the study was to determine the incidences of positive patch test reactions and factors associated with MCI and/or MI contact allergies during the recent decade in Thailand.

METHODS: Medical records of patients who underwent patch testing at Siriraj Hospital from 2009 to 2018 were retrospectively reviewed. The incidences of positive reactions, histories, and clinical data of MCI/MI and MI-alone contact allergy patients were... (More)

BACKGROUND: Methylchloroisothiazolinone, in combination with methylisothiazolinone (MCI/MI), and MI alone are common preservatives. The incidences of MCI/MI and MI-alone contact allergies have risen markedly worldwide, leading to changes in their use in products.

OBJECTIVES: The aim of the study was to determine the incidences of positive patch test reactions and factors associated with MCI and/or MI contact allergies during the recent decade in Thailand.

METHODS: Medical records of patients who underwent patch testing at Siriraj Hospital from 2009 to 2018 were retrospectively reviewed. The incidences of positive reactions, histories, and clinical data of MCI/MI and MI-alone contact allergy patients were analyzed.

RESULTS: Of 2789 patients undergoing patch testing, most were female (76.1%). The mean ± SD age was 42.7 ± 15.7 years. Positive reactions to MCI/MI increased from 2009 to 2016 before declining. The MCI/MI contact allergy was most common in females, middle-aged patients, and those with metal allergy histories, with the hands and arms being the predominant sites. However, MI-alone contact allergy was more common in males and mainly at the trunk. Its incidence significantly declined for the last 5 years.

CONCLUSIONS: The incidences of MCI/MI and MI-alone contact allergies began to decline because the Food and Drug Administration Thailand regulations restricted their use. The risk factors for the allergies reported in this study provide important information for patient care.

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author
; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Dermatitis : contact, atopic, occupational, drug
volume
32
issue
6
pages
375 - 380
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:32209866
  • scopus:85087289380
ISSN
1710-3568
DOI
10.1097/DER.0000000000000537
language
English
LU publication?
no
id
16b2a166-2547-4ea5-9c03-dd176fc391d1
date added to LUP
2021-04-12 13:07:39
date last changed
2024-06-13 09:25:50
@article{16b2a166-2547-4ea5-9c03-dd176fc391d1,
  abstract     = {{<p>BACKGROUND: Methylchloroisothiazolinone, in combination with methylisothiazolinone (MCI/MI), and MI alone are common preservatives. The incidences of MCI/MI and MI-alone contact allergies have risen markedly worldwide, leading to changes in their use in products.</p><p>OBJECTIVES: The aim of the study was to determine the incidences of positive patch test reactions and factors associated with MCI and/or MI contact allergies during the recent decade in Thailand.</p><p>METHODS: Medical records of patients who underwent patch testing at Siriraj Hospital from 2009 to 2018 were retrospectively reviewed. The incidences of positive reactions, histories, and clinical data of MCI/MI and MI-alone contact allergy patients were analyzed.</p><p>RESULTS: Of 2789 patients undergoing patch testing, most were female (76.1%). The mean ± SD age was 42.7 ± 15.7 years. Positive reactions to MCI/MI increased from 2009 to 2016 before declining. The MCI/MI contact allergy was most common in females, middle-aged patients, and those with metal allergy histories, with the hands and arms being the predominant sites. However, MI-alone contact allergy was more common in males and mainly at the trunk. Its incidence significantly declined for the last 5 years.</p><p>CONCLUSIONS: The incidences of MCI/MI and MI-alone contact allergies began to decline because the Food and Drug Administration Thailand regulations restricted their use. The risk factors for the allergies reported in this study provide important information for patient care.</p>}},
  author       = {{Sukakul, Thanisorn and Limphoka, Pichaya and Boonchai, Waranya}},
  issn         = {{1710-3568}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{375--380}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Dermatitis : contact, atopic, occupational, drug}},
  title        = {{Methylchloroisothiazolinone and/or Methylisothiazolinone Contact Allergies in Thailand}},
  url          = {{http://dx.doi.org/10.1097/DER.0000000000000537}},
  doi          = {{10.1097/DER.0000000000000537}},
  volume       = {{32}},
  year         = {{2021}},
}