Putaminal Upregulation of FosB/Delta FosB-Like Immunoreactivity in Parkinson's Disease Patients with Dyskinesia
Lindgren, Hanna LU ; Rylander, Daniella LU ; Iderberg, Hanna LU ; Andersson, M. ; O'Sullivan, S. S. ; Williams, D. R. ; Lees, A. J. and Cenci Nilsson, Angela LU
(2011)
In Journal of Parkinson's Disease
1(4).
p.347-357
- Abstract
- The transcription factor Delta FosB is a mediator of maladaptive neuroplasticity in animal models of Parkinson's disease (PD) and L-DOPA-induced dyskinesia. Using an antibody that recognizes all known isoforms of FosB and Delta FosB, we have examined the expression of these proteins in post-mortem basal ganglia sections from PD patients. The patient cases were classified as being dyskinetic or non-dyskinetic based on their clinical records. Sections from neurologically healthy controls were also included in the study. Compared to both controls and non-dyskinetic cases, the dyskinetic group showed a higher density of FosB/Delta FosB-immunopositive cells in the posterior putamen, which represents the motor region of the striatum in primates.... (More)
- The transcription factor Delta FosB is a mediator of maladaptive neuroplasticity in animal models of Parkinson's disease (PD) and L-DOPA-induced dyskinesia. Using an antibody that recognizes all known isoforms of FosB and Delta FosB, we have examined the expression of these proteins in post-mortem basal ganglia sections from PD patients. The patient cases were classified as being dyskinetic or non-dyskinetic based on their clinical records. Sections from neurologically healthy controls were also included in the study. Compared to both controls and non-dyskinetic cases, the dyskinetic group showed a higher density of FosB/Delta FosB-immunopositive cells in the posterior putamen, which represents the motor region of the striatum in primates. In contrast, the number of FosB/Delta FosB-positive cells did not differ significantly among the groups in the caudate, a region primarily involved with the processing of cognitive and limbic-related information. Only sparse FosB/Delta FosB immunoreactivity was found in the in the pallidum externum and internum, and no significant group differences were detected in these nuclei. The putaminal elevation of FosB/Delta FosB-like immunoreactivity in patients who had been affected by L-DOPA-induced dyskinesia is consistent with results from both rat and non-human primate models of this movement disorder. The present findings support the hypothesis of an involvement of Delta FosB-related transcription factors in the molecular mechanisms of L-DOPA-induced dyskinesia. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3470415
- author
- Lindgren, Hanna
LU
; Rylander, Daniella
LU
; Iderberg, Hanna
LU
; Andersson, M.
; O'Sullivan, S. S.
; Williams, D. R.
; Lees, A. J.
and Cenci Nilsson, Angela
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Motor complications, immediate-early genes, striatonigral, striatopallidal, medium-spiny neurons, neurodegeneration, dopaminergic, therapies
- in
- Journal of Parkinson's Disease
- volume
- 1
- issue
- 4
- pages
- 347 - 357
- publisher
- IOS Press
- external identifiers
-
- wos:000308484300005
- scopus:84863229146
- pmid:23933656
- ISSN
- 1877-718X
- DOI
- 10.3233/JPD-2011-11068
- language
- English
- LU publication?
- yes
- id
- 16b957ac-c6a7-46d8-95cf-f7003aadb1ed (old id 3470415)
- date added to LUP
- 2016-04-01 10:20:40
- date last changed
- 2022-05-13 08:00:00
@article{16b957ac-c6a7-46d8-95cf-f7003aadb1ed,
abstract = {{The transcription factor Delta FosB is a mediator of maladaptive neuroplasticity in animal models of Parkinson's disease (PD) and L-DOPA-induced dyskinesia. Using an antibody that recognizes all known isoforms of FosB and Delta FosB, we have examined the expression of these proteins in post-mortem basal ganglia sections from PD patients. The patient cases were classified as being dyskinetic or non-dyskinetic based on their clinical records. Sections from neurologically healthy controls were also included in the study. Compared to both controls and non-dyskinetic cases, the dyskinetic group showed a higher density of FosB/Delta FosB-immunopositive cells in the posterior putamen, which represents the motor region of the striatum in primates. In contrast, the number of FosB/Delta FosB-positive cells did not differ significantly among the groups in the caudate, a region primarily involved with the processing of cognitive and limbic-related information. Only sparse FosB/Delta FosB immunoreactivity was found in the in the pallidum externum and internum, and no significant group differences were detected in these nuclei. The putaminal elevation of FosB/Delta FosB-like immunoreactivity in patients who had been affected by L-DOPA-induced dyskinesia is consistent with results from both rat and non-human primate models of this movement disorder. The present findings support the hypothesis of an involvement of Delta FosB-related transcription factors in the molecular mechanisms of L-DOPA-induced dyskinesia.}},
author = {{Lindgren, Hanna and Rylander, Daniella and Iderberg, Hanna and Andersson, M. and O'Sullivan, S. S. and Williams, D. R. and Lees, A. J. and Cenci Nilsson, Angela}},
issn = {{1877-718X}},
keywords = {{Motor complications; immediate-early genes; striatonigral; striatopallidal; medium-spiny neurons; neurodegeneration; dopaminergic; therapies}},
language = {{eng}},
number = {{4}},
pages = {{347--357}},
publisher = {{IOS Press}},
series = {{Journal of Parkinson's Disease}},
title = {{Putaminal Upregulation of FosB/Delta FosB-Like Immunoreactivity in Parkinson's Disease Patients with Dyskinesia}},
url = {{http://dx.doi.org/10.3233/JPD-2011-11068}},
doi = {{10.3233/JPD-2011-11068}},
volume = {{1}},
year = {{2011}},
}