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Progression of bone metastases in patients with prostate cancer - automated detection of new lesions and calculation of bone scan index

Kaboteh, Reza; Gjertsson, Peter; Leek, Håkan LU ; Lomsky, Milan; Ohlsson, Mattias LU ; Sjöstrand, Karl LU and Edenbrandt, Lars LU (2013) In EJNMMI Research 3(1).
Abstract

BACKGROUND: The objective of this study was firstly to develop and evaluate an automated method for the detection of new lesions and changes in bone scan index (BSI) in serial bone scans and secondly to evaluate the prognostic value of the method in a group of patients receiving chemotherapy.

METHODS: The automated method for detection of new lesions was evaluated in a group of 266 patients using the classifications by three experienced bone scan readers as a gold standard. The prognostic value of the method was assessed in a group of 31 metastatic hormone-refractory prostate cancer patients who were receiving docetaxel. Cox proportional hazards were used to investigate the association between percentage change in BSI, number of... (More)

BACKGROUND: The objective of this study was firstly to develop and evaluate an automated method for the detection of new lesions and changes in bone scan index (BSI) in serial bone scans and secondly to evaluate the prognostic value of the method in a group of patients receiving chemotherapy.

METHODS: The automated method for detection of new lesions was evaluated in a group of 266 patients using the classifications by three experienced bone scan readers as a gold standard. The prognostic value of the method was assessed in a group of 31 metastatic hormone-refractory prostate cancer patients who were receiving docetaxel. Cox proportional hazards were used to investigate the association between percentage change in BSI, number of new lesions and overall survival. Kaplan-Meier estimates of the survival function were used to indicate a significant difference between patients with an increase/decrease in BSI or those with two or more new lesions or less than two new lesions.

RESULTS: The automated method detected progression defined as two or more new lesions with a sensitivity of 93% and a specificity of 87%. In the treatment group, both BSI changes and the number of new metastases were significantly associated with survival. Two-year survival for patients with increasing and decreasing BSI from baseline to follow-up scans were 18% and 57% (p = 0.03), respectively. Two-year survival for patients fulfilling and not fulfilling the criterion of two or more new lesions was 35% and 38% (n.s.), respectively.

CONCLUSIONS: An automated method can be used to calculate the number of new lesions and changes in BSI in serial bone scans. These imaging biomarkers contained prognostic information in a small group of patients with prostate cancer receiving chemotherapy.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Journal Article
in
EJNMMI Research
volume
3
issue
1
publisher
BioMed Central
external identifiers
  • scopus:84887289342
  • wos:000209435800064
ISSN
2191-219X
DOI
10.1186/2191-219X-3-64
language
English
LU publication?
yes
id
16c4097c-3870-4e48-9d11-7a59e5cb2b44
date added to LUP
2017-04-24 14:19:47
date last changed
2018-01-16 13:25:43
@article{16c4097c-3870-4e48-9d11-7a59e5cb2b44,
  abstract     = {<p>BACKGROUND: The objective of this study was firstly to develop and evaluate an automated method for the detection of new lesions and changes in bone scan index (BSI) in serial bone scans and secondly to evaluate the prognostic value of the method in a group of patients receiving chemotherapy.</p><p>METHODS: The automated method for detection of new lesions was evaluated in a group of 266 patients using the classifications by three experienced bone scan readers as a gold standard. The prognostic value of the method was assessed in a group of 31 metastatic hormone-refractory prostate cancer patients who were receiving docetaxel. Cox proportional hazards were used to investigate the association between percentage change in BSI, number of new lesions and overall survival. Kaplan-Meier estimates of the survival function were used to indicate a significant difference between patients with an increase/decrease in BSI or those with two or more new lesions or less than two new lesions.</p><p>RESULTS: The automated method detected progression defined as two or more new lesions with a sensitivity of 93% and a specificity of 87%. In the treatment group, both BSI changes and the number of new metastases were significantly associated with survival. Two-year survival for patients with increasing and decreasing BSI from baseline to follow-up scans were 18% and 57% (p = 0.03), respectively. Two-year survival for patients fulfilling and not fulfilling the criterion of two or more new lesions was 35% and 38% (n.s.), respectively.</p><p>CONCLUSIONS: An automated method can be used to calculate the number of new lesions and changes in BSI in serial bone scans. These imaging biomarkers contained prognostic information in a small group of patients with prostate cancer receiving chemotherapy.</p>},
  author       = {Kaboteh, Reza and Gjertsson, Peter and Leek, Håkan and Lomsky, Milan and Ohlsson, Mattias and Sjöstrand, Karl and Edenbrandt, Lars},
  issn         = {2191-219X},
  keyword      = {Journal Article},
  language     = {eng},
  month        = {08},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {EJNMMI Research},
  title        = {Progression of bone metastases in patients with prostate cancer - automated detection of new lesions and calculation of bone scan index},
  url          = {http://dx.doi.org/10.1186/2191-219X-3-64},
  volume       = {3},
  year         = {2013},
}