Alterations of telomere length and DNA methylation in hairdressers: A cross-sectional study.
Li, Huiqi LU ; Åkerman, Gabriella LU ; Lidén, Carola ; Alhamdow, Ayman LU ; Wojdacz, Tomasz K ; Broberg Palmgren, Karin LU
and Albin, Maria
LU
(2016)
In Environmental and Molecular Mutagenesis
57(2).
p.159-167
- Abstract
- Working as hairdressers has been associated with increased risk for cancer, particularly bladder cancer. To evaluate if current hairdressers have elevated risks of adverse health effects, we measured several biomarkers related to cancer-related DNA alterations. We enrolled 295 hairdressers and 92 non-hairdressers (all female non-smokers) from Stockholm and southern Sweden. Questionnaire data were collected for each participant, including work tasks for the hairdressers. We measured telomere length in peripheral blood leucocytes using quantitative PCR and DNA methylation status of genes relevant for bladder cancer using methylation sensitive high resolution melting analysis. The hairdressers had shorter telomeres (β = -0.069, P = 0.019)... (More)
- Working as hairdressers has been associated with increased risk for cancer, particularly bladder cancer. To evaluate if current hairdressers have elevated risks of adverse health effects, we measured several biomarkers related to cancer-related DNA alterations. We enrolled 295 hairdressers and 92 non-hairdressers (all female non-smokers) from Stockholm and southern Sweden. Questionnaire data were collected for each participant, including work tasks for the hairdressers. We measured telomere length in peripheral blood leucocytes using quantitative PCR and DNA methylation status of genes relevant for bladder cancer using methylation sensitive high resolution melting analysis. The hairdressers had shorter telomeres (β = -0.069, P = 0.019) compared with non-hairdressers. Shorter telomeres were found in hairdressers up to 32 years old performing hair waving more than once per week as compared with hairdressers in the same age group performing hair waving less often (β = -0.12, P = 0.037). Hair waving was associated with less frequent CDKN2A methylation (odds ratio, OR = 0.19, P = 0.033). Shorter telomeres in hairdressers may indicate a genotoxic effect. Performing hair waving was associated with short telomere length, although the effect was only observed in young hairdressers. No clear patterns were discerned with regard to DNA methylation of bladder cancer-related genes. The observed changes of methylation were not all in the expected direction and warrant further investigation. Environ. Mol. Mutagen., 2015. © 2015 Wiley Periodicals, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8505615
- author
- Li, Huiqi
LU
; Åkerman, Gabriella
LU
; Lidén, Carola
; Alhamdow, Ayman
LU
; Wojdacz, Tomasz K
; Broberg Palmgren, Karin
LU
and Albin, Maria
LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Environmental and Molecular Mutagenesis
- volume
- 57
- issue
- 2
- pages
- 159 - 167
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:26637967
- scopus:84957882614
- wos:000370333500006
- pmid:26637967
- ISSN
- 1098-2280
- DOI
- 10.1002/em.21991
- language
- English
- LU publication?
- yes
- id
- 16cea407-ad3d-49c8-9895-135958c66ff6 (old id 8505615)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26637967?dopt=Abstract
- date added to LUP
- 2016-04-04 08:56:34
- date last changed
- 2022-03-15 17:21:48
@article{16cea407-ad3d-49c8-9895-135958c66ff6,
abstract = {{Working as hairdressers has been associated with increased risk for cancer, particularly bladder cancer. To evaluate if current hairdressers have elevated risks of adverse health effects, we measured several biomarkers related to cancer-related DNA alterations. We enrolled 295 hairdressers and 92 non-hairdressers (all female non-smokers) from Stockholm and southern Sweden. Questionnaire data were collected for each participant, including work tasks for the hairdressers. We measured telomere length in peripheral blood leucocytes using quantitative PCR and DNA methylation status of genes relevant for bladder cancer using methylation sensitive high resolution melting analysis. The hairdressers had shorter telomeres (β = -0.069, P = 0.019) compared with non-hairdressers. Shorter telomeres were found in hairdressers up to 32 years old performing hair waving more than once per week as compared with hairdressers in the same age group performing hair waving less often (β = -0.12, P = 0.037). Hair waving was associated with less frequent CDKN2A methylation (odds ratio, OR = 0.19, P = 0.033). Shorter telomeres in hairdressers may indicate a genotoxic effect. Performing hair waving was associated with short telomere length, although the effect was only observed in young hairdressers. No clear patterns were discerned with regard to DNA methylation of bladder cancer-related genes. The observed changes of methylation were not all in the expected direction and warrant further investigation. Environ. Mol. Mutagen., 2015. © 2015 Wiley Periodicals, Inc.}},
author = {{Li, Huiqi and Åkerman, Gabriella and Lidén, Carola and Alhamdow, Ayman and Wojdacz, Tomasz K and Broberg Palmgren, Karin and Albin, Maria}},
issn = {{1098-2280}},
language = {{eng}},
number = {{2}},
pages = {{159--167}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Environmental and Molecular Mutagenesis}},
title = {{Alterations of telomere length and DNA methylation in hairdressers: A cross-sectional study.}},
url = {{http://dx.doi.org/10.1002/em.21991}},
doi = {{10.1002/em.21991}},
volume = {{57}},
year = {{2016}},
}