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Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.

Nguyen, Huu Phuc; Björkqvist, Maria LU ; Bode, Felix J; Stephan, Michael and von Hörsten, Stephan (2010) In PLoS Currents 2.
Abstract
To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.
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author
organization
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type
Contribution to journal
publication status
published
subject
in
PLoS Currents
volume
2
publisher
Public Library of Science
external identifiers
  • PMID:20981129
  • Scopus:84873337254
ISSN
2157-3999
DOI
10.1371/currents.RRN1190
language
English
LU publication?
yes
id
08f77473-f58c-4e91-9629-5c6112cbca7d (old id 1710672)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20981129?dopt=Abstract
date added to LUP
2010-11-05 14:15:42
date last changed
2017-01-01 07:54:39
@article{08f77473-f58c-4e91-9629-5c6112cbca7d,
  abstract     = {To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.},
  articleno    = {RRN1190},
  author       = {Nguyen, Huu Phuc and Björkqvist, Maria and Bode, Felix J and Stephan, Michael and von Hörsten, Stephan},
  issn         = {2157-3999},
  language     = {eng},
  publisher    = {Public Library of Science},
  series       = {PLoS Currents},
  title        = {Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.},
  url          = {http://dx.doi.org/10.1371/currents.RRN1190},
  volume       = {2},
  year         = {2010},
}