Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.
Nguyen, Huu Phuc ; Björkqvist, Maria LU
; Bode, Felix J
; Stephan, Michael
and von Hörsten, Stephan
(2010)
In PLoS Currents
2.
- Abstract
- To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1710672
- author
- Nguyen, Huu Phuc
; Björkqvist, Maria
LU
; Bode, Felix J
; Stephan, Michael
and von Hörsten, Stephan
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS Currents
- volume
- 2
- article number
- RRN1190
- publisher
- Public Library of Science
- external identifiers
-
- pmid:20981129
- scopus:84873337254
- pmid:20981129
- ISSN
- 2157-3999
- DOI
- 10.1371/currents.RRN1190
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
- id
- 08f77473-f58c-4e91-9629-5c6112cbca7d (old id 1710672)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20981129?dopt=Abstract
- date added to LUP
- 2016-04-04 09:45:01
- date last changed
- 2025-01-06 12:36:06
@article{08f77473-f58c-4e91-9629-5c6112cbca7d,
abstract = {{To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.}},
author = {{Nguyen, Huu Phuc and Björkqvist, Maria and Bode, Felix J and Stephan, Michael and von Hörsten, Stephan}},
issn = {{2157-3999}},
language = {{eng}},
publisher = {{Public Library of Science}},
series = {{PLoS Currents}},
title = {{Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.}},
url = {{http://dx.doi.org/10.1371/currents.RRN1190}},
doi = {{10.1371/currents.RRN1190}},
volume = {{2}},
year = {{2010}},
}