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In vitro Studies and Safety Assessment of Doppler Ultrasound as a Diagnostic Tool in Rhinosinusitis.

Sahlstrand Johnson, Pernilla LU ; Jönsson, Peter LU ; Persson, Hans W; Holmer, Nils-Gunnar; Jannert, Magnus and Jansson, Tomas (2010) In Ultrasound in Medicine and Biology 36. p.2123-2131
Abstract
We have previously proposed the use of Doppler ultrasound to noninvasively stage a sinus infection. In this study, we first investigated the acoustic properties of nonpurulent and mucopurulent sinus secretions. The density, viscosity, speed of sound and attenuation of 18 samples of sinus fluid were examined. We then assessed the safety of the method by determining the temperature increase when ultrasound is transmitted through a bone sample of the same thickness as the anterior wall of the maxillary sinus. As a measure of the probability to generate acoustic streaming, we determined the ratio of sound attenuation over the viscosity of the sinus fluid and compared this with the value obtained from acoustic streaming measurements on a model... (More)
We have previously proposed the use of Doppler ultrasound to noninvasively stage a sinus infection. In this study, we first investigated the acoustic properties of nonpurulent and mucopurulent sinus secretions. The density, viscosity, speed of sound and attenuation of 18 samples of sinus fluid were examined. We then assessed the safety of the method by determining the temperature increase when ultrasound is transmitted through a bone sample of the same thickness as the anterior wall of the maxillary sinus. As a measure of the probability to generate acoustic streaming, we determined the ratio of sound attenuation over the viscosity of the sinus fluid and compared this with the value obtained from acoustic streaming measurements on a model system. The results indicated that detectable levels of acoustic streaming can be generated in serous sinus fluid, which has a low viscosity, but is very unlikely in mucopurulent secretions. The attenuation of the mucopurulent sinus fluid was 10 times higher than that of the serous cyst fluid, but the viscosity of the mucopurulent secretion was a thousand times higher than that of serous fluid. The safety experiments gave a temperature increase of the bone of <1.5°C at I(spta) of 640 mW/cm(2), below the temperature increase considered to be harmful by the World Federation for Ultrasound in Medicine and Biology. (E-mail: pernilla.sahlstrand_johnson@med.lu.se). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Ultrasound in Medicine and Biology
volume
36
pages
2123 - 2131
publisher
Elsevier
external identifiers
  • wos:000284334400019
  • pmid:20950936
  • scopus:78449273106
ISSN
0301-5629
DOI
10.1016/j.ultrasmedbio.2010.08.018
language
English
LU publication?
yes
id
940b8bc1-54eb-4723-95b0-6e3cafb6868c (old id 1711089)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20950936?dopt=Abstract
date added to LUP
2010-11-05 15:27:06
date last changed
2018-05-29 09:25:49
@article{940b8bc1-54eb-4723-95b0-6e3cafb6868c,
  abstract     = {We have previously proposed the use of Doppler ultrasound to noninvasively stage a sinus infection. In this study, we first investigated the acoustic properties of nonpurulent and mucopurulent sinus secretions. The density, viscosity, speed of sound and attenuation of 18 samples of sinus fluid were examined. We then assessed the safety of the method by determining the temperature increase when ultrasound is transmitted through a bone sample of the same thickness as the anterior wall of the maxillary sinus. As a measure of the probability to generate acoustic streaming, we determined the ratio of sound attenuation over the viscosity of the sinus fluid and compared this with the value obtained from acoustic streaming measurements on a model system. The results indicated that detectable levels of acoustic streaming can be generated in serous sinus fluid, which has a low viscosity, but is very unlikely in mucopurulent secretions. The attenuation of the mucopurulent sinus fluid was 10 times higher than that of the serous cyst fluid, but the viscosity of the mucopurulent secretion was a thousand times higher than that of serous fluid. The safety experiments gave a temperature increase of the bone of &lt;1.5°C at I(spta) of 640 mW/cm(2), below the temperature increase considered to be harmful by the World Federation for Ultrasound in Medicine and Biology. (E-mail: pernilla.sahlstrand_johnson@med.lu.se).},
  author       = {Sahlstrand Johnson, Pernilla and Jönsson, Peter and Persson, Hans W and Holmer, Nils-Gunnar and Jannert, Magnus and Jansson, Tomas},
  issn         = {0301-5629},
  language     = {eng},
  pages        = {2123--2131},
  publisher    = {Elsevier},
  series       = {Ultrasound in Medicine and Biology},
  title        = {In vitro Studies and Safety Assessment of Doppler Ultrasound as a Diagnostic Tool in Rhinosinusitis.},
  url          = {http://dx.doi.org/10.1016/j.ultrasmedbio.2010.08.018},
  volume       = {36},
  year         = {2010},
}