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Colour change in the human histamine wheal made visible by LYYN: a technique to enhance colour differences.

Holm, Olle; Lindell, Erik and Malm, Lars LU (2010) In Skin Research and Technology 16. p.385-389
Abstract
Background: Colour differences in photographs can be enhanced using a digital image-processing technique called LYYN. Objective: To investigate colour changes in the histamine wheal after skin prick tests (SPTs). Methods: Histamine SPTs were performed on the forearm of six medical students, and the reactions of the skin were photographed every 2 min for 30 min. Colour differences in the photographs were then enhanced using the LYYN technique. These images were processed using ImageJ to yield numerical values. Results: In the LYYN-processed images, there was a rapid colour change in the histamine wheals between the 18th and the 20th minute (P<0.01). Histamine perfusion in isolated rabbit ears indicated vasodilatation in post-capillary... (More)
Background: Colour differences in photographs can be enhanced using a digital image-processing technique called LYYN. Objective: To investigate colour changes in the histamine wheal after skin prick tests (SPTs). Methods: Histamine SPTs were performed on the forearm of six medical students, and the reactions of the skin were photographed every 2 min for 30 min. Colour differences in the photographs were then enhanced using the LYYN technique. These images were processed using ImageJ to yield numerical values. Results: In the LYYN-processed images, there was a rapid colour change in the histamine wheals between the 18th and the 20th minute (P<0.01). Histamine perfusion in isolated rabbit ears indicated vasodilatation in post-capillary vessels and desensitized histamine 1 (H1) receptors after a mean of 17 min. It is possible that a similar desensitization takes place in the human histamine wheal, and a study of two histamine SPTs 90 min apart at the same site supports this hypothesis. Conclusion: The LYYN technique was sensitive enough to discover a rapid colour change in the histamine wheal, a change that has not been described before. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Skin Research and Technology
volume
16
pages
385 - 389
publisher
Wiley-Blackwell
external identifiers
  • wos:000282980800001
  • pmid:20923457
  • scopus:78650451887
ISSN
0909-752X
DOI
10.1111/j.1600-0846.2010.00457.x
language
English
LU publication?
yes
id
d41272a5-be77-4181-b68d-3fc1bbb0ff1b (old id 1711390)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20923457?dopt=Abstract
date added to LUP
2010-11-05 12:54:12
date last changed
2018-05-29 10:27:40
@article{d41272a5-be77-4181-b68d-3fc1bbb0ff1b,
  abstract     = {Background: Colour differences in photographs can be enhanced using a digital image-processing technique called LYYN. Objective: To investigate colour changes in the histamine wheal after skin prick tests (SPTs). Methods: Histamine SPTs were performed on the forearm of six medical students, and the reactions of the skin were photographed every 2 min for 30 min. Colour differences in the photographs were then enhanced using the LYYN technique. These images were processed using ImageJ to yield numerical values. Results: In the LYYN-processed images, there was a rapid colour change in the histamine wheals between the 18th and the 20th minute (P&lt;0.01). Histamine perfusion in isolated rabbit ears indicated vasodilatation in post-capillary vessels and desensitized histamine 1 (H1) receptors after a mean of 17 min. It is possible that a similar desensitization takes place in the human histamine wheal, and a study of two histamine SPTs 90 min apart at the same site supports this hypothesis. Conclusion: The LYYN technique was sensitive enough to discover a rapid colour change in the histamine wheal, a change that has not been described before.},
  author       = {Holm, Olle and Lindell, Erik and Malm, Lars},
  issn         = {0909-752X},
  language     = {eng},
  pages        = {385--389},
  publisher    = {Wiley-Blackwell},
  series       = {Skin Research and Technology},
  title        = {Colour change in the human histamine wheal made visible by LYYN: a technique to enhance colour differences.},
  url          = {http://dx.doi.org/10.1111/j.1600-0846.2010.00457.x},
  volume       = {16},
  year         = {2010},
}