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Low Production of Reactive Oxygen Species Drives Systemic Lupus Erythematosus

Urbonaviciute, Vilma ; Luo, Huqiao ; Sjöwall, Christopher ; Bengtsson, Anders LU and Holmdahl, Rikard LU (2019) In Trends in Molecular Medicine
Abstract

Systemic lupus erythematosus (SLE) is a common autoimmune disease. Recent findings have shown that a major single nucleotide variant predisposing to SLE is associated with low production of reactive oxygen species (ROS). A variant amino acid in a frequent NCF1 allele causing deficient ROS production leads to an exaggerated type I interferon (IFN) response, earlier disease onset, and higher susceptibility to SLE. It is the so far strongest identified single nucleotide variant, with an odds ratio (OR) of >3 and an allele frequency of >10%. Its functional role is in sharp contrast to the earlier belief that excessive ROS production is exclusively pathogenic rather than protective. It opens new possibilities to understand the... (More)

Systemic lupus erythematosus (SLE) is a common autoimmune disease. Recent findings have shown that a major single nucleotide variant predisposing to SLE is associated with low production of reactive oxygen species (ROS). A variant amino acid in a frequent NCF1 allele causing deficient ROS production leads to an exaggerated type I interferon (IFN) response, earlier disease onset, and higher susceptibility to SLE. It is the so far strongest identified single nucleotide variant, with an odds ratio (OR) of >3 and an allele frequency of >10%. Its functional role is in sharp contrast to the earlier belief that excessive ROS production is exclusively pathogenic rather than protective. It opens new possibilities to understand the pathogenesis of SLE and to develop novel diagnostics and treatment strategies.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
interferon, NADPH oxidase, neutrophil cytosolic factor 1, reactive oxygen species, systemic lupus erythematosus
in
Trends in Molecular Medicine
publisher
Elsevier
external identifiers
  • scopus:85068561488
  • pmid:31303528
ISSN
1471-4914
DOI
10.1016/j.molmed.2019.06.001
language
English
LU publication?
yes
id
171cbec6-f94a-4734-8da4-c12fd9828048
date added to LUP
2019-07-18 09:24:51
date last changed
2023-11-19 11:28:11
@misc{171cbec6-f94a-4734-8da4-c12fd9828048,
  abstract     = {{<p>Systemic lupus erythematosus (SLE) is a common autoimmune disease. Recent findings have shown that a major single nucleotide variant predisposing to SLE is associated with low production of reactive oxygen species (ROS). A variant amino acid in a frequent NCF1 allele causing deficient ROS production leads to an exaggerated type I interferon (IFN) response, earlier disease onset, and higher susceptibility to SLE. It is the so far strongest identified single nucleotide variant, with an odds ratio (OR) of &gt;3 and an allele frequency of &gt;10%. Its functional role is in sharp contrast to the earlier belief that excessive ROS production is exclusively pathogenic rather than protective. It opens new possibilities to understand the pathogenesis of SLE and to develop novel diagnostics and treatment strategies.</p>}},
  author       = {{Urbonaviciute, Vilma and Luo, Huqiao and Sjöwall, Christopher and Bengtsson, Anders and Holmdahl, Rikard}},
  issn         = {{1471-4914}},
  keywords     = {{interferon; NADPH oxidase; neutrophil cytosolic factor 1; reactive oxygen species; systemic lupus erythematosus}},
  language     = {{eng}},
  month        = {{07}},
  publisher    = {{Elsevier}},
  series       = {{Trends in Molecular Medicine}},
  title        = {{Low Production of Reactive Oxygen Species Drives Systemic Lupus Erythematosus}},
  url          = {{http://dx.doi.org/10.1016/j.molmed.2019.06.001}},
  doi          = {{10.1016/j.molmed.2019.06.001}},
  year         = {{2019}},
}