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Gene expression regulation and lineage evolution: the North and South tale of the hybrid polyploid Squalius alburnoides complex

Pala, Irene LU ; Schartl, Manfred; Brito, Miguel; Vacas, Joana Malta and Coelho, Maria Manuela (2010) In Royal Society of London. Proceedings B. Biological Sciences 277(1699). p.3519-3525
Abstract
The evolution of hybrid polyploid vertebrates, their viability and their perpetuation over evolutionary time have always been questions of great interest. However, little is known about the impact of hybridization and polyploidization on the regulatory networks that guarantee the appropriate quantitative and qualitative gene expression programme. The Squalius alburnoides complex of hybrid fish is an attractive system to address these questions, as it includes a wide variety of diploid and polyploid forms, and intricate systems of genetic exchange. Through the study of genome-specific allele expression of seven housekeeping and tissue-specific genes, we found that a gene copy silencing mechanism of dosage compensation exists throughout the... (More)
The evolution of hybrid polyploid vertebrates, their viability and their perpetuation over evolutionary time have always been questions of great interest. However, little is known about the impact of hybridization and polyploidization on the regulatory networks that guarantee the appropriate quantitative and qualitative gene expression programme. The Squalius alburnoides complex of hybrid fish is an attractive system to address these questions, as it includes a wide variety of diploid and polyploid forms, and intricate systems of genetic exchange. Through the study of genome-specific allele expression of seven housekeeping and tissue-specific genes, we found that a gene copy silencing mechanism of dosage compensation exists throughout the distribution range of the complex. Here we show that the allele-specific patterns of silencing vary within the complex, according to the geographical origin and the type of genome involved in the hybridization process. In southern populations, triploids of S. alburnoides show an overall tendency for silencing the allele from the minority genome, while northern population polyploids exhibit preferential biallelic gene expression patterns, irrespective of genomic composition. The present findings further suggest that gene copy silencing and variable expression of specific allele combinations may be important processes in vertebrate polyploid evolution. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hybrid lineage, allele silencing, allopolyploid, gene expression, evolution
in
Royal Society of London. Proceedings B. Biological Sciences
volume
277
issue
1699
pages
3519 - 3525
publisher
Royal Society
external identifiers
  • wos:000283448800018
  • scopus:78149245728
ISSN
1471-2954
DOI
10.1098/rspb.2010.1071
language
English
LU publication?
yes
id
b43558c1-58b0-473f-9df3-edce2a57ba68 (old id 1720232)
date added to LUP
2010-12-06 11:37:46
date last changed
2018-05-29 11:54:05
@article{b43558c1-58b0-473f-9df3-edce2a57ba68,
  abstract     = {The evolution of hybrid polyploid vertebrates, their viability and their perpetuation over evolutionary time have always been questions of great interest. However, little is known about the impact of hybridization and polyploidization on the regulatory networks that guarantee the appropriate quantitative and qualitative gene expression programme. The Squalius alburnoides complex of hybrid fish is an attractive system to address these questions, as it includes a wide variety of diploid and polyploid forms, and intricate systems of genetic exchange. Through the study of genome-specific allele expression of seven housekeeping and tissue-specific genes, we found that a gene copy silencing mechanism of dosage compensation exists throughout the distribution range of the complex. Here we show that the allele-specific patterns of silencing vary within the complex, according to the geographical origin and the type of genome involved in the hybridization process. In southern populations, triploids of S. alburnoides show an overall tendency for silencing the allele from the minority genome, while northern population polyploids exhibit preferential biallelic gene expression patterns, irrespective of genomic composition. The present findings further suggest that gene copy silencing and variable expression of specific allele combinations may be important processes in vertebrate polyploid evolution.},
  author       = {Pala, Irene and Schartl, Manfred and Brito, Miguel and Vacas, Joana Malta and Coelho, Maria Manuela},
  issn         = {1471-2954},
  keyword      = {hybrid lineage,allele silencing,allopolyploid,gene expression,evolution},
  language     = {eng},
  number       = {1699},
  pages        = {3519--3525},
  publisher    = {Royal Society},
  series       = {Royal Society of London. Proceedings B. Biological Sciences},
  title        = {Gene expression regulation and lineage evolution: the North and South tale of the hybrid polyploid Squalius alburnoides complex},
  url          = {http://dx.doi.org/10.1098/rspb.2010.1071},
  volume       = {277},
  year         = {2010},
}