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Alignment between PIN1 Polarity and Microtubule Orientation in the Shoot Apical Meristem Reveals a Tight Coupling between Morphogenesis and Auxin Transport

Heisler, Marcus G.; Hamant, Olivier; Krupinski, Pawel LU ; Uyttewaal, Magalie; Ohno, Carolyn; Jönsson, Henrik LU ; Traas, Jan and Meyerowitz, Elliot M. (2010) In PLoS Biology 8(10).
Abstract
Morphogenesis during multicellular development is regulated by intercellular signaling molecules as well as by the mechanical properties of individual cells. In particular, normal patterns of organogenesis in plants require coordination between growth direction and growth magnitude. How this is achieved remains unclear. Here we show that in Arabidopsis thaliana, auxin patterning and cellular growth are linked through a correlated pattern of auxin efflux carrier localization and cortical microtubule orientation. Our experiments reveal that both PIN1 localization and microtubule array orientation are likely to respond to a shared upstream regulator that appears to be biomechanical in nature. Lastly, through mathematical modeling we show that... (More)
Morphogenesis during multicellular development is regulated by intercellular signaling molecules as well as by the mechanical properties of individual cells. In particular, normal patterns of organogenesis in plants require coordination between growth direction and growth magnitude. How this is achieved remains unclear. Here we show that in Arabidopsis thaliana, auxin patterning and cellular growth are linked through a correlated pattern of auxin efflux carrier localization and cortical microtubule orientation. Our experiments reveal that both PIN1 localization and microtubule array orientation are likely to respond to a shared upstream regulator that appears to be biomechanical in nature. Lastly, through mathematical modeling we show that such a biophysical coupling could mediate the feedback loop between auxin and its transport that underlies plant phyllotaxis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS Biology
volume
8
issue
10
publisher
Public Library of Science
external identifiers
  • wos:000283495100015
  • scopus:78149401660
ISSN
1544-9173
DOI
10.1371/journal.pbio.1000516
language
English
LU publication?
yes
id
b5fab2a1-7f7d-4a80-88b1-5f6740ac519c (old id 1720247)
date added to LUP
2010-12-09 13:29:51
date last changed
2018-06-24 04:29:14
@article{b5fab2a1-7f7d-4a80-88b1-5f6740ac519c,
  abstract     = {Morphogenesis during multicellular development is regulated by intercellular signaling molecules as well as by the mechanical properties of individual cells. In particular, normal patterns of organogenesis in plants require coordination between growth direction and growth magnitude. How this is achieved remains unclear. Here we show that in Arabidopsis thaliana, auxin patterning and cellular growth are linked through a correlated pattern of auxin efflux carrier localization and cortical microtubule orientation. Our experiments reveal that both PIN1 localization and microtubule array orientation are likely to respond to a shared upstream regulator that appears to be biomechanical in nature. Lastly, through mathematical modeling we show that such a biophysical coupling could mediate the feedback loop between auxin and its transport that underlies plant phyllotaxis.},
  author       = {Heisler, Marcus G. and Hamant, Olivier and Krupinski, Pawel and Uyttewaal, Magalie and Ohno, Carolyn and Jönsson, Henrik and Traas, Jan and Meyerowitz, Elliot M.},
  issn         = {1544-9173},
  language     = {eng},
  number       = {10},
  publisher    = {Public Library of Science},
  series       = {PLoS Biology},
  title        = {Alignment between PIN1 Polarity and Microtubule Orientation in the Shoot Apical Meristem Reveals a Tight Coupling between Morphogenesis and Auxin Transport},
  url          = {http://dx.doi.org/10.1371/journal.pbio.1000516},
  volume       = {8},
  year         = {2010},
}