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An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes

Haukvik, Unn Kristin; Saetre, Peter; McNeil, Thomas LU ; Bjerkan, Petr S.; Andreassen, Ole A.; Werge, Thomas; Jonsson, Erik G. and Agartz, Ingrid (2010) In Progress in Neuro-Psychopharmacology and Biological Psychiatry 34(7). p.1259-1265
Abstract
Background Smaller hippocampal volume has repeatedly been reported in schizophrenia patients Obstetric complications (OCs) and single nucleotide polymorphism (SNP) variation in schizophrenia susceptibility genes have independently been related to hippocampal volume We investigated putative independent and interaction effects of severe hypoxia-related OCs and variation in four hypoxia-regulated schizophrenia susceptibility genes (BDNF, DTNBP1, GRM3 and NRG1) on hippocampal volume in schizophrenia patients and healthy controls. Methods Clinical assessment, structural MRI scans, and blood samples for genotyping of 32 SNPs were obtained from 54 schizophrenia patients and 53 control subjects Information on obstetric complications was collected... (More)
Background Smaller hippocampal volume has repeatedly been reported in schizophrenia patients Obstetric complications (OCs) and single nucleotide polymorphism (SNP) variation in schizophrenia susceptibility genes have independently been related to hippocampal volume We investigated putative independent and interaction effects of severe hypoxia-related OCs and variation in four hypoxia-regulated schizophrenia susceptibility genes (BDNF, DTNBP1, GRM3 and NRG1) on hippocampal volume in schizophrenia patients and healthy controls. Methods Clinical assessment, structural MRI scans, and blood samples for genotyping of 32 SNPs were obtained from 54 schizophrenia patients and 53 control subjects Information on obstetric complications was collected from original birth records Results Severe OCs were related to hippocampal volume in both patients with schizophrenia and healthy control subjects Of the 32 SNPs studied, effects of severe OCs on hippocampal volume were associated with allele variation in GRM3 rs13242038, but the interaction effect was not specific for schizophrenia. SNP variation in any of the four investigated genes alone did not significantly affect hippocampal volume. Conclusions. The findings suggest a gene-environment (G x E) interaction between GRM3 gene variants and severe obstetric complications on hippocampus volume, independent of a diagnosis of schizophrenia Due to the modest sample size, the results must be considered preliminary and require replication in independent samples. (C) 2010 Elsevier Inc All rights reserved (Less)
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organization
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Contribution to journal
publication status
published
subject
keywords
Obstetric complications, Hypoxia-regulated genes, GRM3, Hippocampus, Schizophrenia
in
Progress in Neuro-Psychopharmacology and Biological Psychiatry
volume
34
issue
7
pages
1259 - 1265
publisher
Elsevier
external identifiers
  • wos:000283038300014
  • scopus:77956424719
ISSN
0278-5846
DOI
10.1016/j.pnpbp.2010.07.001
language
English
LU publication?
yes
id
8c91e9c9-7443-4787-bc3c-edb9f167fabd (old id 1720619)
date added to LUP
2010-12-03 14:49:32
date last changed
2018-07-01 03:05:06
@article{8c91e9c9-7443-4787-bc3c-edb9f167fabd,
  abstract     = {Background Smaller hippocampal volume has repeatedly been reported in schizophrenia patients Obstetric complications (OCs) and single nucleotide polymorphism (SNP) variation in schizophrenia susceptibility genes have independently been related to hippocampal volume We investigated putative independent and interaction effects of severe hypoxia-related OCs and variation in four hypoxia-regulated schizophrenia susceptibility genes (BDNF, DTNBP1, GRM3 and NRG1) on hippocampal volume in schizophrenia patients and healthy controls. Methods Clinical assessment, structural MRI scans, and blood samples for genotyping of 32 SNPs were obtained from 54 schizophrenia patients and 53 control subjects Information on obstetric complications was collected from original birth records Results Severe OCs were related to hippocampal volume in both patients with schizophrenia and healthy control subjects Of the 32 SNPs studied, effects of severe OCs on hippocampal volume were associated with allele variation in GRM3 rs13242038, but the interaction effect was not specific for schizophrenia. SNP variation in any of the four investigated genes alone did not significantly affect hippocampal volume. Conclusions. The findings suggest a gene-environment (G x E) interaction between GRM3 gene variants and severe obstetric complications on hippocampus volume, independent of a diagnosis of schizophrenia Due to the modest sample size, the results must be considered preliminary and require replication in independent samples. (C) 2010 Elsevier Inc All rights reserved},
  author       = {Haukvik, Unn Kristin and Saetre, Peter and McNeil, Thomas and Bjerkan, Petr S. and Andreassen, Ole A. and Werge, Thomas and Jonsson, Erik G. and Agartz, Ingrid},
  issn         = {0278-5846},
  keyword      = {Obstetric complications,Hypoxia-regulated genes,GRM3,Hippocampus,Schizophrenia},
  language     = {eng},
  number       = {7},
  pages        = {1259--1265},
  publisher    = {Elsevier},
  series       = {Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  title        = {An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes},
  url          = {http://dx.doi.org/10.1016/j.pnpbp.2010.07.001},
  volume       = {34},
  year         = {2010},
}