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Intracellular ZnO Nanorods Conjugated with Protoporphyrin for Local Mediated Photochemistry and Efficient Treatment of Single Cancer Cell

Kishwar, S.; Asif, M. H.; Nur, O.; Willander, M. and Larsson, Per-Olof LU (2010) In Nanoscale Research Letters 5(10). p.1669-1674
Abstract
ZnO nanorods (NRs) with high surface area to volume ratio and biocompatibility is used as an efficient photosensitizer carrier system and at the same time providing intrinsic white light needed to achieve cancer cell necrosis. In this letter, ZnO nanorods used for the treatment of breast cancer cell (T47D) are presented. To adjust the sample for intracellular experiments, we have grown the ZnO nanorods on the tip of borosilicate glass capillaries (0.5 mu m diameter) by aqueous chemical growth technique. The grown ZnO nanorods were conjugated using protoporphyrin dimethyl ester (PPDME), which absorbs the light emitted by the ZnO nanorods. Mechanism of cytotoxicity appears to involve the generation of singlet oxygen inside the cell. The... (More)
ZnO nanorods (NRs) with high surface area to volume ratio and biocompatibility is used as an efficient photosensitizer carrier system and at the same time providing intrinsic white light needed to achieve cancer cell necrosis. In this letter, ZnO nanorods used for the treatment of breast cancer cell (T47D) are presented. To adjust the sample for intracellular experiments, we have grown the ZnO nanorods on the tip of borosilicate glass capillaries (0.5 mu m diameter) by aqueous chemical growth technique. The grown ZnO nanorods were conjugated using protoporphyrin dimethyl ester (PPDME), which absorbs the light emitted by the ZnO nanorods. Mechanism of cytotoxicity appears to involve the generation of singlet oxygen inside the cell. The novel findings of cell-localized toxicity indicate a potential application of PPDME-conjugated ZnO NRs in the necrosis of breast cancer cell within few minutes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Protoporphyrin dimethyl ester, Photodynamic therapy, ZnO nanorods, Cancer cell necrosis
in
Nanoscale Research Letters
volume
5
issue
10
pages
1669 - 1674
publisher
Springer
external identifiers
  • wos:000283124800022
  • scopus:77958481479
ISSN
1931-7573
DOI
10.1007/s11671-010-9693-z
language
English
LU publication?
yes
id
9e6edf62-32ff-4955-886b-845f6a63a40d (old id 1720686)
date added to LUP
2010-12-03 14:19:20
date last changed
2018-06-03 03:23:55
@article{9e6edf62-32ff-4955-886b-845f6a63a40d,
  abstract     = {ZnO nanorods (NRs) with high surface area to volume ratio and biocompatibility is used as an efficient photosensitizer carrier system and at the same time providing intrinsic white light needed to achieve cancer cell necrosis. In this letter, ZnO nanorods used for the treatment of breast cancer cell (T47D) are presented. To adjust the sample for intracellular experiments, we have grown the ZnO nanorods on the tip of borosilicate glass capillaries (0.5 mu m diameter) by aqueous chemical growth technique. The grown ZnO nanorods were conjugated using protoporphyrin dimethyl ester (PPDME), which absorbs the light emitted by the ZnO nanorods. Mechanism of cytotoxicity appears to involve the generation of singlet oxygen inside the cell. The novel findings of cell-localized toxicity indicate a potential application of PPDME-conjugated ZnO NRs in the necrosis of breast cancer cell within few minutes.},
  author       = {Kishwar, S. and Asif, M. H. and Nur, O. and Willander, M. and Larsson, Per-Olof},
  issn         = {1931-7573},
  keyword      = {Protoporphyrin dimethyl ester,Photodynamic therapy,ZnO nanorods,Cancer cell necrosis},
  language     = {eng},
  number       = {10},
  pages        = {1669--1674},
  publisher    = {Springer},
  series       = {Nanoscale Research Letters},
  title        = {Intracellular ZnO Nanorods Conjugated with Protoporphyrin for Local Mediated Photochemistry and Efficient Treatment of Single Cancer Cell},
  url          = {http://dx.doi.org/10.1007/s11671-010-9693-z},
  volume       = {5},
  year         = {2010},
}