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Multimodal imaging to study the morphochemistry of basal cell carcinoma

Vogler, Nadine; Meyer, Tobias; Akimov, Denis; Latka, Ines; Krafft, Christoph; Bendsöe, Niels LU ; Svanberg, Katarina LU ; Dietzek, Benjamin and Popp, Juergen (2010) In Journal of Biophotonics 3(10-11). p.728-736
Abstract
Basal cell carcinoma is the most abundant malignant neoplasm in humans, the pathology of which is characterized by an abnormal proliferation of basal cells. Basal cell carcinoma can show a variety of different morphologies, which are based on different cellular biology. Furthermore, the carcinoma often grows invisibly to the eye imbedded in the surrounding skin. Therefore, in some cases its clinical detection is challenging. Thus, our work aims at establishing an unsupervised tissue classification method based on multimodal imaging and the application of chemometrics to discriminate basal cell carcinoma from non-diseased tissue. A case study applying multimodal imaging to ex-vivo sections of basal cell carcinoma is presented. In doing so,... (More)
Basal cell carcinoma is the most abundant malignant neoplasm in humans, the pathology of which is characterized by an abnormal proliferation of basal cells. Basal cell carcinoma can show a variety of different morphologies, which are based on different cellular biology. Furthermore, the carcinoma often grows invisibly to the eye imbedded in the surrounding skin. Therefore, in some cases its clinical detection is challenging. Thus, our work aims at establishing an unsupervised tissue classification method based on multimodal imaging and the application of chemometrics to discriminate basal cell carcinoma from non-diseased tissue. A case study applying multimodal imaging to ex-vivo sections of basal cell carcinoma is presented. In doing so, we apply a combination of various linear and non-linear imaging modalities, i.e. fluorescence, Raman and second-harmonic generation microscopy, to study the morphochemistry of basal cell carcinoma. The joint information content obtained by such multimodal approach in studying various aspects of the malignant tissue alterations associated with basal cell carcinoma is discussed. [GRAPHICS] Multimodal imaging combining coherent anti-Stokes Raman scattering, second-harmonic generation and two-photo fluorescence is combined with Raman spectroscopy to investigate the morphochemistry of human basal cell carcinoma. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Biophotonics
volume
3
issue
10-11
pages
728 - 736
publisher
John Wiley & Sons
external identifiers
  • wos:000283273700012
  • scopus:77957330740
ISSN
1864-063X
DOI
10.1002/jbio.201000071
language
English
LU publication?
yes
id
856672aa-2ab5-4c7c-b466-75108db7874b (old id 1720803)
date added to LUP
2010-12-03 14:17:47
date last changed
2018-07-08 03:07:26
@article{856672aa-2ab5-4c7c-b466-75108db7874b,
  abstract     = {Basal cell carcinoma is the most abundant malignant neoplasm in humans, the pathology of which is characterized by an abnormal proliferation of basal cells. Basal cell carcinoma can show a variety of different morphologies, which are based on different cellular biology. Furthermore, the carcinoma often grows invisibly to the eye imbedded in the surrounding skin. Therefore, in some cases its clinical detection is challenging. Thus, our work aims at establishing an unsupervised tissue classification method based on multimodal imaging and the application of chemometrics to discriminate basal cell carcinoma from non-diseased tissue. A case study applying multimodal imaging to ex-vivo sections of basal cell carcinoma is presented. In doing so, we apply a combination of various linear and non-linear imaging modalities, i.e. fluorescence, Raman and second-harmonic generation microscopy, to study the morphochemistry of basal cell carcinoma. The joint information content obtained by such multimodal approach in studying various aspects of the malignant tissue alterations associated with basal cell carcinoma is discussed. [GRAPHICS] Multimodal imaging combining coherent anti-Stokes Raman scattering, second-harmonic generation and two-photo fluorescence is combined with Raman spectroscopy to investigate the morphochemistry of human basal cell carcinoma.},
  author       = {Vogler, Nadine and Meyer, Tobias and Akimov, Denis and Latka, Ines and Krafft, Christoph and Bendsöe, Niels and Svanberg, Katarina and Dietzek, Benjamin and Popp, Juergen},
  issn         = {1864-063X},
  language     = {eng},
  number       = {10-11},
  pages        = {728--736},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Biophotonics},
  title        = {Multimodal imaging to study the morphochemistry of basal cell carcinoma},
  url          = {http://dx.doi.org/10.1002/jbio.201000071},
  volume       = {3},
  year         = {2010},
}