Effect of postconditioning on infarct size in patients with ST elevation myocardial infarction
(2010) In Heart 96(21). p.1710-1715- Abstract
- Background Small studies suggest that postconditioning reperfusion interrupted by brief repetitive cycles of reocclusions, may protect the myocardium in the clinical setting. Objective To test the hypothesis that postconditioning limits infarct size in relation to the area at risk in patients with ST elevation myocardial infarction (STEMI). Methods 76 patients (aged 37-87 years) eligible for primary percutaneous coronary intervention due to STEMI were randomised to standard percutaneous coronary intervention (n=38) or postconditioning, consisting of four cycles of 60 s reperfusion and 60 s of reocclusion before permanent reperfusion (n=38). Results The area at risk was determined from angiographic abnormally contracting segments. Infarct... (More)
- Background Small studies suggest that postconditioning reperfusion interrupted by brief repetitive cycles of reocclusions, may protect the myocardium in the clinical setting. Objective To test the hypothesis that postconditioning limits infarct size in relation to the area at risk in patients with ST elevation myocardial infarction (STEMI). Methods 76 patients (aged 37-87 years) eligible for primary percutaneous coronary intervention due to STEMI were randomised to standard percutaneous coronary intervention (n=38) or postconditioning, consisting of four cycles of 60 s reperfusion and 60 s of reocclusion before permanent reperfusion (n=38). Results The area at risk was determined from angiographic abnormally contracting segments. Infarct size was quantified from delayed enhancement MRI on days 6-9. Infarct size, expressed in relation to the area at risk, did not differ between the control group (44%; 30, 56) (median and quartiles) and the post-conditioned group (47%; 23, 63). The slope of the regression lines relating infarct size to the area at risk differed between the two groups. Infarct size was significantly (p=0.001) reduced by postconditioning in patients with large areas at risk. The area under the curve and peak troponin T release and CKMB during 48 h did not differ between patients in the control and postconditioning groups. Conclusions This prospective, randomised trial suggests that postconditioning does not reduce infarct size in patients with STEMI in the overall study group. The data indicate that postconditioning may be of value in patients with large areas at risk. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1720891
- author
- Sorensson, Peder ; Saleh, Nawzad ; Bouvier, Frederic ; Bohm, Felix ; Settergren, Magnus ; Caidahl, Kenneth ; Tornvall, Per ; Arheden, Håkan LU ; Ryden, Lars and Pernow, John
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Heart
- volume
- 96
- issue
- 21
- pages
- 1710 - 1715
- publisher
- BMJ Publishing Group
- external identifiers
-
- wos:000283050700006
- scopus:78049281398
- pmid:20956486
- ISSN
- 1355-6037
- DOI
- 10.1136/hrt.2010.199430
- language
- English
- LU publication?
- yes
- id
- f7b7ba24-b29a-496a-b531-ff4eacb6c275 (old id 1720891)
- date added to LUP
- 2016-04-01 10:21:22
- date last changed
- 2022-03-12 04:55:36
@article{f7b7ba24-b29a-496a-b531-ff4eacb6c275,
abstract = {{Background Small studies suggest that postconditioning reperfusion interrupted by brief repetitive cycles of reocclusions, may protect the myocardium in the clinical setting. Objective To test the hypothesis that postconditioning limits infarct size in relation to the area at risk in patients with ST elevation myocardial infarction (STEMI). Methods 76 patients (aged 37-87 years) eligible for primary percutaneous coronary intervention due to STEMI were randomised to standard percutaneous coronary intervention (n=38) or postconditioning, consisting of four cycles of 60 s reperfusion and 60 s of reocclusion before permanent reperfusion (n=38). Results The area at risk was determined from angiographic abnormally contracting segments. Infarct size was quantified from delayed enhancement MRI on days 6-9. Infarct size, expressed in relation to the area at risk, did not differ between the control group (44%; 30, 56) (median and quartiles) and the post-conditioned group (47%; 23, 63). The slope of the regression lines relating infarct size to the area at risk differed between the two groups. Infarct size was significantly (p=0.001) reduced by postconditioning in patients with large areas at risk. The area under the curve and peak troponin T release and CKMB during 48 h did not differ between patients in the control and postconditioning groups. Conclusions This prospective, randomised trial suggests that postconditioning does not reduce infarct size in patients with STEMI in the overall study group. The data indicate that postconditioning may be of value in patients with large areas at risk.}},
author = {{Sorensson, Peder and Saleh, Nawzad and Bouvier, Frederic and Bohm, Felix and Settergren, Magnus and Caidahl, Kenneth and Tornvall, Per and Arheden, Håkan and Ryden, Lars and Pernow, John}},
issn = {{1355-6037}},
language = {{eng}},
number = {{21}},
pages = {{1710--1715}},
publisher = {{BMJ Publishing Group}},
series = {{Heart}},
title = {{Effect of postconditioning on infarct size in patients with ST elevation myocardial infarction}},
url = {{http://dx.doi.org/10.1136/hrt.2010.199430}},
doi = {{10.1136/hrt.2010.199430}},
volume = {{96}},
year = {{2010}},
}