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No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain

Nicholl, Barbara I.; Holliday, Kate L.; Macfarlane, Gary J.; Thomson, Wendy; Davies, Kelly A.; O'Neill, Terence W.; Bartfai, Gyorgy; Boonen, Steven; Casanueva, Felipe and Finn, Joseph D., et al. (2010) In Annals of the Rheumatic Diseases 69(11). p.2009-2012
Abstract
Objectives The aim of this study was to investigate the association between the catechol-O-methyltransferase (COMT) 'pain sensitivity' haplotypes and chronic widespread pain (CWP) in two distinct cohorts. Methods Cases of CWP and controls free of pain were selected from two population-based studies: the Epidemiology of Functional Disorders study (EPIFUND) (UK) and the European Male Ageing Study (European). The number of cases and controls were 164 and 172, and 204 and 935, respectively. Identical American College of Rheumatology criteria were used in both studies to ascertain CWP status. The EPIFUND study had three time points and cases were classified as subjects with CWP at two or three time points and controls as those free of pain at... (More)
Objectives The aim of this study was to investigate the association between the catechol-O-methyltransferase (COMT) 'pain sensitivity' haplotypes and chronic widespread pain (CWP) in two distinct cohorts. Methods Cases of CWP and controls free of pain were selected from two population-based studies: the Epidemiology of Functional Disorders study (EPIFUND) (UK) and the European Male Ageing Study (European). The number of cases and controls were 164 and 172, and 204 and 935, respectively. Identical American College of Rheumatology criteria were used in both studies to ascertain CWP status. The EPIFUND study had three time points and cases were classified as subjects with CWP at two or three time points and controls as those free of pain at all three time points. Four single nucleotide polymorphisms (SNP): rs6269, rs4633, rs4818 and rs4680 (V158M) were genotyped using Sequenom technology. Allele and genotype frequencies were compared and haplotype analysis was conducted using PLINK software. Results No differences in allele or genotype frequencies for any of the four SNP were observed between cases and controls for either cohort. Haplotype analysis also showed no difference in the frequency of haplotypes between cases and controls. Conclusions There was no evidence of association between the COMT 'pain sensitivity' haplotypes and CWP in two population-based cohorts. (Less)
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publication status
published
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in
Annals of the Rheumatic Diseases
volume
69
issue
11
pages
2009 - 2012
publisher
British Medical Association
external identifiers
  • wos:000283060600020
  • scopus:78149489881
ISSN
1468-2060
DOI
10.1136/ard.2009.126086
language
English
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yes
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1ebb3f6f-22f2-4ae1-a74d-0ff1d5c7d836 (old id 1721200)
date added to LUP
2010-12-01 11:32:20
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2018-05-29 12:32:20
@article{1ebb3f6f-22f2-4ae1-a74d-0ff1d5c7d836,
  abstract     = {Objectives The aim of this study was to investigate the association between the catechol-O-methyltransferase (COMT) 'pain sensitivity' haplotypes and chronic widespread pain (CWP) in two distinct cohorts. Methods Cases of CWP and controls free of pain were selected from two population-based studies: the Epidemiology of Functional Disorders study (EPIFUND) (UK) and the European Male Ageing Study (European). The number of cases and controls were 164 and 172, and 204 and 935, respectively. Identical American College of Rheumatology criteria were used in both studies to ascertain CWP status. The EPIFUND study had three time points and cases were classified as subjects with CWP at two or three time points and controls as those free of pain at all three time points. Four single nucleotide polymorphisms (SNP): rs6269, rs4633, rs4818 and rs4680 (V158M) were genotyped using Sequenom technology. Allele and genotype frequencies were compared and haplotype analysis was conducted using PLINK software. Results No differences in allele or genotype frequencies for any of the four SNP were observed between cases and controls for either cohort. Haplotype analysis also showed no difference in the frequency of haplotypes between cases and controls. Conclusions There was no evidence of association between the COMT 'pain sensitivity' haplotypes and CWP in two population-based cohorts.},
  author       = {Nicholl, Barbara I. and Holliday, Kate L. and Macfarlane, Gary J. and Thomson, Wendy and Davies, Kelly A. and O'Neill, Terence W. and Bartfai, Gyorgy and Boonen, Steven and Casanueva, Felipe and Finn, Joseph D. and Forti, Gianni and Giwercman, Aleksander and Huhtaniemi, Ilpo T. and Kula, Krzysztof and Punab, Margus and Silman, Alan J. and Vanderschueren, Dirk and Wu, Frederick C. W. and McBeth, John},
  issn         = {1468-2060},
  language     = {eng},
  number       = {11},
  pages        = {2009--2012},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain},
  url          = {http://dx.doi.org/10.1136/ard.2009.126086},
  volume       = {69},
  year         = {2010},
}