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Gender Differences in the Scandinavian Cystic Fibrosis Population

Olesen, Hanne Vebert; Pressler, Tacjana; Hjelte, Lena; Mared, Lena LU ; Lindblad, Anders; Knudsen, Per Kristian; Laerum, Birger N. and Johannesson, Marie (2010) In Pediatric Pulmonology 45(10). p.959-965
Abstract
Aims: To explore whether gender differences in the Scandinavian Cystic Fibrosis (CF) patients exist in the areas of key clinical parameters, complications, and medication. Methods: Cross-sectional data on 890 (416 female) pancreatic insufficient CF patients were evaluated regarding chronic infection, body mass index, lung function, medication, and diabetes, as well as data of Pseudomonas infection status, antibiotic treatment and hospitalization from 1-year follow-up. Results: We found no differences in lung function, body mass index, or frequency of diabetes. The adult group consisted of more males than females (208:168). We found no significant difference in prevalence of chronic Pseudomonas aeruginosa infection, but during the follow-up... (More)
Aims: To explore whether gender differences in the Scandinavian Cystic Fibrosis (CF) patients exist in the areas of key clinical parameters, complications, and medication. Methods: Cross-sectional data on 890 (416 female) pancreatic insufficient CF patients were evaluated regarding chronic infection, body mass index, lung function, medication, and diabetes, as well as data of Pseudomonas infection status, antibiotic treatment and hospitalization from 1-year follow-up. Results: We found no differences in lung function, body mass index, or frequency of diabetes. The adult group consisted of more males than females (208:168). We found no significant difference in prevalence of chronic Pseudomonas aeruginosa infection, but during the follow-up the incidence of new chronic infection was higher in adult females (10/33 vs. 4/56). Females had higher prevalence of Burkholderia infection (21/416 vs. 11/474). Adult females had more days on intravenous antibiotics (median 39 vs. 26 days/year), and days in hospital (median 2 vs. 0 days/year). More adult females received inhaled and oral steroids. In the pediatric cohort, females were treated more often with macrolides as an anti-inflammatory agent. Conclusion: We found no gender difference in key clinical parameters in our CF population. However, our study showed a higher risk of Pseudomonas and Burkholderia infection among the female patients. Additionally, we found that female patients require more intensified treatment regarding antibiotics, macrolides, steroids and days of hospitalization, indicating a true female disadvantage even with modern aggressive treatment. The finding of more males than females in the adult population suggesting a male advantage, warrants a mortality study. Pediatr Pulmonol. 2010; 45:959-965. (C) 2010 Wiley-Liss, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
steroid, lung function, Burkholderia, Pseudomonas, cystic fibrosis, gender
in
Pediatric Pulmonology
volume
45
issue
10
pages
959 - 965
publisher
John Wiley & Sons
external identifiers
  • wos:000282993700003
  • scopus:79952539612
ISSN
8755-6863
DOI
10.1002/ppul.21265
language
English
LU publication?
yes
id
0b9f04be-765d-40b6-9df1-81da679021a3 (old id 1725525)
date added to LUP
2010-11-23 17:10:21
date last changed
2018-05-29 12:26:54
@article{0b9f04be-765d-40b6-9df1-81da679021a3,
  abstract     = {Aims: To explore whether gender differences in the Scandinavian Cystic Fibrosis (CF) patients exist in the areas of key clinical parameters, complications, and medication. Methods: Cross-sectional data on 890 (416 female) pancreatic insufficient CF patients were evaluated regarding chronic infection, body mass index, lung function, medication, and diabetes, as well as data of Pseudomonas infection status, antibiotic treatment and hospitalization from 1-year follow-up. Results: We found no differences in lung function, body mass index, or frequency of diabetes. The adult group consisted of more males than females (208:168). We found no significant difference in prevalence of chronic Pseudomonas aeruginosa infection, but during the follow-up the incidence of new chronic infection was higher in adult females (10/33 vs. 4/56). Females had higher prevalence of Burkholderia infection (21/416 vs. 11/474). Adult females had more days on intravenous antibiotics (median 39 vs. 26 days/year), and days in hospital (median 2 vs. 0 days/year). More adult females received inhaled and oral steroids. In the pediatric cohort, females were treated more often with macrolides as an anti-inflammatory agent. Conclusion: We found no gender difference in key clinical parameters in our CF population. However, our study showed a higher risk of Pseudomonas and Burkholderia infection among the female patients. Additionally, we found that female patients require more intensified treatment regarding antibiotics, macrolides, steroids and days of hospitalization, indicating a true female disadvantage even with modern aggressive treatment. The finding of more males than females in the adult population suggesting a male advantage, warrants a mortality study. Pediatr Pulmonol. 2010; 45:959-965. (C) 2010 Wiley-Liss, Inc.},
  author       = {Olesen, Hanne Vebert and Pressler, Tacjana and Hjelte, Lena and Mared, Lena and Lindblad, Anders and Knudsen, Per Kristian and Laerum, Birger N. and Johannesson, Marie},
  issn         = {8755-6863},
  keyword      = {steroid,lung function,Burkholderia,Pseudomonas,cystic fibrosis,gender},
  language     = {eng},
  number       = {10},
  pages        = {959--965},
  publisher    = {John Wiley & Sons},
  series       = {Pediatric Pulmonology},
  title        = {Gender Differences in the Scandinavian Cystic Fibrosis Population},
  url          = {http://dx.doi.org/10.1002/ppul.21265},
  volume       = {45},
  year         = {2010},
}