Advanced

Determination of non-steroidal anti-inflammatory drugs in sewage sludge by direct hollow fiber supported liquid membrane extraction and liquid chromatography-mass spectrometry

Sagrista, Ester; Larsson, Estelle LU ; Ezoddin, Maryam; Hidalgo, Manuela; Salvado, Victoria and Jönsson, Jan Åke LU (2010) In Journal of Chromatography A 1217(40). p.6153-6158
Abstract
In this study, a three-phase hollow fiber liquid-phase microextraction (HF-LPME) method combined with liquid chromatography-mass spectrometry was developed for direct determination of four non-steroidal anti-inflammatory drugs (ketoprofen, naproxen, diclofenac and ibuprofen) in sewage sludge. The drugs were extracted from non-spiked and spiked slurry samples with different amounts of sludge into an organic phase and then back-extracted into an aqueous phase held in the lumen of the hollow fiber. High enrichment factors ranging from 2761 to 3254 in pure water were achieved. In sludge samples, repeatability and inter-clay precision were tested with relative standard deviation values between 10-18% and 7-15%, respectively. Average... (More)
In this study, a three-phase hollow fiber liquid-phase microextraction (HF-LPME) method combined with liquid chromatography-mass spectrometry was developed for direct determination of four non-steroidal anti-inflammatory drugs (ketoprofen, naproxen, diclofenac and ibuprofen) in sewage sludge. The drugs were extracted from non-spiked and spiked slurry samples with different amounts of sludge into an organic phase and then back-extracted into an aqueous phase held in the lumen of the hollow fiber. High enrichment factors ranging from 2761 to 3254 in pure water were achieved. In sludge samples, repeatability and inter-clay precision were tested with relative standard deviation values between 10-18% and 7-15%, respectively. Average concentrations of 29 +/- 9, 138 +/- 2, 39 +/- 5 and 122 +/- 7 ng/g were determined in dried sludge from Kallby sewage treatment plant (Sweden) for ketoprofen, naproxen, diclofenac and ibuprofen, respectively. (C) 2010 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
NSAIDs, Sewage sludge, Hollow fiber supported liquid membrane, HF-LPME
in
Journal of Chromatography A
volume
1217
issue
40
pages
6153 - 6158
publisher
Elsevier
external identifiers
  • wos:000282725800004
  • scopus:77956652058
ISSN
0021-9673
DOI
10.1016/j.chroma.2010.08.005
language
English
LU publication?
yes
id
d00661c0-6ec4-4bdd-b5a4-c6ce54706b4d (old id 1727041)
date added to LUP
2010-11-23 09:48:47
date last changed
2018-06-24 04:08:15
@article{d00661c0-6ec4-4bdd-b5a4-c6ce54706b4d,
  abstract     = {In this study, a three-phase hollow fiber liquid-phase microextraction (HF-LPME) method combined with liquid chromatography-mass spectrometry was developed for direct determination of four non-steroidal anti-inflammatory drugs (ketoprofen, naproxen, diclofenac and ibuprofen) in sewage sludge. The drugs were extracted from non-spiked and spiked slurry samples with different amounts of sludge into an organic phase and then back-extracted into an aqueous phase held in the lumen of the hollow fiber. High enrichment factors ranging from 2761 to 3254 in pure water were achieved. In sludge samples, repeatability and inter-clay precision were tested with relative standard deviation values between 10-18% and 7-15%, respectively. Average concentrations of 29 +/- 9, 138 +/- 2, 39 +/- 5 and 122 +/- 7 ng/g were determined in dried sludge from Kallby sewage treatment plant (Sweden) for ketoprofen, naproxen, diclofenac and ibuprofen, respectively. (C) 2010 Elsevier B.V. All rights reserved.},
  author       = {Sagrista, Ester and Larsson, Estelle and Ezoddin, Maryam and Hidalgo, Manuela and Salvado, Victoria and Jönsson, Jan Åke},
  issn         = {0021-9673},
  keyword      = {NSAIDs,Sewage sludge,Hollow fiber supported liquid membrane,HF-LPME},
  language     = {eng},
  number       = {40},
  pages        = {6153--6158},
  publisher    = {Elsevier},
  series       = {Journal of Chromatography A},
  title        = {Determination of non-steroidal anti-inflammatory drugs in sewage sludge by direct hollow fiber supported liquid membrane extraction and liquid chromatography-mass spectrometry},
  url          = {http://dx.doi.org/10.1016/j.chroma.2010.08.005},
  volume       = {1217},
  year         = {2010},
}