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Latent Autoimmune Diabetes in Adults Differs Genetically From Classical Type 1 Diabetes Diagnosed After the Age of 35 Years

Andersen, Mette K. ; Lundgren, Virve ; Turunen, Joni A. ; Forsblom, Carol ; Isomaa, Bo ; Groop, Per-Henrik ; Groop, Leif LU and Tuomi, Tiinamaija (2010) In Diabetes Care 33(9). p.2062-2064
Abstract
OBJECTIVE- We studied differences between patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes, and classical type 1 diabetes diagnosed after age 35 years. RESEARCH DESIGN AND METHODS- Polymorphisms in HLA-DQB1, INS, PTPN22, and CTLA4 were genotyped in patients with LADA (n = 213), type 1 diabetes diagnosed at >35 years of age (T1D(>35y); n = 257) or <20 years of age (T1D(<20y); n = 158), and type 2 diabetes. RESULTS- Although patients with LADA had an increased frequency of HLA-DQB1 and PTPN22 risk genotypes and alleles compared with type 2 diabetic subjects, the frequency was significantly lower compared with T1D(>35y) patients. Genotype frequencies, measures of insulin secretion, and metabolic traits... (More)
OBJECTIVE- We studied differences between patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes, and classical type 1 diabetes diagnosed after age 35 years. RESEARCH DESIGN AND METHODS- Polymorphisms in HLA-DQB1, INS, PTPN22, and CTLA4 were genotyped in patients with LADA (n = 213), type 1 diabetes diagnosed at >35 years of age (T1D(>35y); n = 257) or <20 years of age (T1D(<20y); n = 158), and type 2 diabetes. RESULTS- Although patients with LADA had an increased frequency of HLA-DQB1 and PTPN22 risk genotypes and alleles compared with type 2 diabetic subjects, the frequency was significantly lower compared with T1D(>35y) patients. Genotype frequencies, measures of insulin secretion, and metabolic traits within LADA differed according to GAD antibody (GADA) quartiles, but even the highest quartile differed from type 1 diabetes. Having two or more risk genotypes was associated with lower C-peptide concentrations in LADA. CONCLUSIONS- LADA patients differed genetically and phenotypically from both T1D(>35y) and type 2 diabetic patients in a manner dependent on GADA levels. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
33
issue
9
pages
2062 - 2064
publisher
American Diabetes Association
external identifiers
  • wos:000282560300031
  • scopus:79951607479
  • pmid:20805278
ISSN
1935-5548
DOI
10.2337/dc09-2188
language
English
LU publication?
yes
id
52b2c1d9-55c8-49cb-bc55-1572601f7181 (old id 1727931)
date added to LUP
2016-04-01 13:07:57
date last changed
2024-05-08 05:20:05
@article{52b2c1d9-55c8-49cb-bc55-1572601f7181,
  abstract     = {{OBJECTIVE- We studied differences between patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes, and classical type 1 diabetes diagnosed after age 35 years. RESEARCH DESIGN AND METHODS- Polymorphisms in HLA-DQB1, INS, PTPN22, and CTLA4 were genotyped in patients with LADA (n = 213), type 1 diabetes diagnosed at &gt;35 years of age (T1D(&gt;35y); n = 257) or &lt;20 years of age (T1D(&lt;20y); n = 158), and type 2 diabetes. RESULTS- Although patients with LADA had an increased frequency of HLA-DQB1 and PTPN22 risk genotypes and alleles compared with type 2 diabetic subjects, the frequency was significantly lower compared with T1D(&gt;35y) patients. Genotype frequencies, measures of insulin secretion, and metabolic traits within LADA differed according to GAD antibody (GADA) quartiles, but even the highest quartile differed from type 1 diabetes. Having two or more risk genotypes was associated with lower C-peptide concentrations in LADA. CONCLUSIONS- LADA patients differed genetically and phenotypically from both T1D(&gt;35y) and type 2 diabetic patients in a manner dependent on GADA levels.}},
  author       = {{Andersen, Mette K. and Lundgren, Virve and Turunen, Joni A. and Forsblom, Carol and Isomaa, Bo and Groop, Per-Henrik and Groop, Leif and Tuomi, Tiinamaija}},
  issn         = {{1935-5548}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{2062--2064}},
  publisher    = {{American Diabetes Association}},
  series       = {{Diabetes Care}},
  title        = {{Latent Autoimmune Diabetes in Adults Differs Genetically From Classical Type 1 Diabetes Diagnosed After the Age of 35 Years}},
  url          = {{http://dx.doi.org/10.2337/dc09-2188}},
  doi          = {{10.2337/dc09-2188}},
  volume       = {{33}},
  year         = {{2010}},
}