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One-Hour Plasma Glucose Identifies Insulin Resistance and beta-Cell Dysfunction in Individuals With Normal Glucose Tolerance Cross-sectional data from the Relationship between Insulin Sensitivity and Cardiovascular Risk (RISC) study

Manco, Melania; Panunzi, Simona; Macfarlane, David P.; Golay, Alain; Melander, Olle LU ; Konrad, Thomas; Petrie, John R. and Mingrone, Geltrude (2010) In Diabetes Care 33(9). p.2090-2097
Abstract
OBJECTIVE- Some individuals with normal glucose tolerance (NGT) exhibit a 1-h excursion of plasma glucose during oral glucose tolerance testing as high as that of individuals with impaired glucose tolerance (IGT). The aim of this study was to characterize their metabolic phenotype. RESEARCH DESIGN AND METHODS- A total of 1,205 healthy volunteers (aged 29-61 years) underwent assessment of 1) oral glucose tolerance and 2) insulin sensitivity (standardized euglycemic-hyperinsulinemic clamp), as part of the Relationship between Insulin Sensitivity and Cardiovascular Risk (RISC) study. RESULTS- One-hour plasma glucose correlated better than 2-h plasma glucose with total insulin secretion (r = 0.43), beta-cell glucose sensitivity (r = -0.46),... (More)
OBJECTIVE- Some individuals with normal glucose tolerance (NGT) exhibit a 1-h excursion of plasma glucose during oral glucose tolerance testing as high as that of individuals with impaired glucose tolerance (IGT). The aim of this study was to characterize their metabolic phenotype. RESEARCH DESIGN AND METHODS- A total of 1,205 healthy volunteers (aged 29-61 years) underwent assessment of 1) oral glucose tolerance and 2) insulin sensitivity (standardized euglycemic-hyperinsulinemic clamp), as part of the Relationship between Insulin Sensitivity and Cardiovascular Risk (RISC) study. RESULTS- One-hour plasma glucose correlated better than 2-h plasma glucose with total insulin secretion (r = 0.43), beta-cell glucose sensitivity (r = -0.46), and beta-cell rate sensitivity (r = -0.18). Receiver operating characteristic analysis identified 8.95 mmol/l as the best cutoff value for prediction of IGT from 1-h plasma glucose (sensitivity 77% and specificity 80%). Participants with NGT with 1-h plasma glucose >8.95 mmol/l had larger waist circumference, higher BMI, lower insulin sensitivity, higher fasting glucose, and higher insulin secretion than their counterparts with 1-h plasma glucose <= 8.95 mmol/l (P < 0.001 for all comparisons). Moreover, they exhibited lower beta-cell glucose sensitivity (P < 0.001), beta-cell rate sensitivity (P < 0.001), and potentiation factor (P = 0.026). When compared with conventionally defined IGT, they were not different in waist circumference and BMI, hepatic insulin extraction, beta-cell glucose sensitivity, beta-cell rate sensitivity, and potentiation factor but did have greater insulin sensitivity along with reduced basal (P = 0.001) and total insulin secretion (P = 0.002). CONCLUSIONS- Higher values of 1-h plasma glucose may identify an intermediate condition between NGT and IGT characterized by greater insulin resistance, reduced beta-cell glucose sensitivity, and reduced beta-cell rate sensitivity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
33
issue
9
pages
2090 - 2097
publisher
American Diabetes Association
external identifiers
  • wos:000282560300038
  • scopus:79951663631
ISSN
1935-5548
DOI
10.2337/dc09-2261
language
English
LU publication?
yes
id
6f63d8f1-e487-49ee-9150-7b8a6295f70f (old id 1727941)
date added to LUP
2010-11-23 09:25:25
date last changed
2018-06-24 04:10:26
@article{6f63d8f1-e487-49ee-9150-7b8a6295f70f,
  abstract     = {OBJECTIVE- Some individuals with normal glucose tolerance (NGT) exhibit a 1-h excursion of plasma glucose during oral glucose tolerance testing as high as that of individuals with impaired glucose tolerance (IGT). The aim of this study was to characterize their metabolic phenotype. RESEARCH DESIGN AND METHODS- A total of 1,205 healthy volunteers (aged 29-61 years) underwent assessment of 1) oral glucose tolerance and 2) insulin sensitivity (standardized euglycemic-hyperinsulinemic clamp), as part of the Relationship between Insulin Sensitivity and Cardiovascular Risk (RISC) study. RESULTS- One-hour plasma glucose correlated better than 2-h plasma glucose with total insulin secretion (r = 0.43), beta-cell glucose sensitivity (r = -0.46), and beta-cell rate sensitivity (r = -0.18). Receiver operating characteristic analysis identified 8.95 mmol/l as the best cutoff value for prediction of IGT from 1-h plasma glucose (sensitivity 77% and specificity 80%). Participants with NGT with 1-h plasma glucose &gt;8.95 mmol/l had larger waist circumference, higher BMI, lower insulin sensitivity, higher fasting glucose, and higher insulin secretion than their counterparts with 1-h plasma glucose &lt;= 8.95 mmol/l (P &lt; 0.001 for all comparisons). Moreover, they exhibited lower beta-cell glucose sensitivity (P &lt; 0.001), beta-cell rate sensitivity (P &lt; 0.001), and potentiation factor (P = 0.026). When compared with conventionally defined IGT, they were not different in waist circumference and BMI, hepatic insulin extraction, beta-cell glucose sensitivity, beta-cell rate sensitivity, and potentiation factor but did have greater insulin sensitivity along with reduced basal (P = 0.001) and total insulin secretion (P = 0.002). CONCLUSIONS- Higher values of 1-h plasma glucose may identify an intermediate condition between NGT and IGT characterized by greater insulin resistance, reduced beta-cell glucose sensitivity, and reduced beta-cell rate sensitivity.},
  author       = {Manco, Melania and Panunzi, Simona and Macfarlane, David P. and Golay, Alain and Melander, Olle and Konrad, Thomas and Petrie, John R. and Mingrone, Geltrude},
  issn         = {1935-5548},
  language     = {eng},
  number       = {9},
  pages        = {2090--2097},
  publisher    = {American Diabetes Association},
  series       = {Diabetes Care},
  title        = {One-Hour Plasma Glucose Identifies Insulin Resistance and beta-Cell Dysfunction in Individuals With Normal Glucose Tolerance Cross-sectional data from the Relationship between Insulin Sensitivity and Cardiovascular Risk (RISC) study},
  url          = {http://dx.doi.org/10.2337/dc09-2261},
  volume       = {33},
  year         = {2010},
}