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Hormonal exposures and the risk of uveal melanoma

Behrens, Thomas ; Kaerlev, Linda ; Cree, Ian ; Lutz, Jean-Michel ; Afonso, Noemia ; Eriksson, Mikael LU orcid ; Guenel, Pascal ; Merletti, Franco ; Morales-Suarez-Varela, Maria and Stengrevics, Aivars , et al. (2010) In Cancer Causes and Control 21(10). p.1625-1634
Abstract
Several studies suggest that hormonal mechanisms may be associated with the development of uveal melanoma. Therefore, the association between the risk of uveal melanoma and exposure to hormonal exposures was investigated in a case-control study from nine European countries. Incident cases of uveal melanoma were frequency-matched to population and hospital controls by country, age, and sex. Female subjects were asked about their reproductive history, use of menopausal hormone replacement therapy and oral contraceptives. Among men, occupational handling of oils while working with transformers or capacitors which contain polychlorinated biphenyls (PCB) was solicited. Unconditional logistic regression analyses were calculated, adjusting for... (More)
Several studies suggest that hormonal mechanisms may be associated with the development of uveal melanoma. Therefore, the association between the risk of uveal melanoma and exposure to hormonal exposures was investigated in a case-control study from nine European countries. Incident cases of uveal melanoma were frequency-matched to population and hospital controls by country, age, and sex. Female subjects were asked about their reproductive history, use of menopausal hormone replacement therapy and oral contraceptives. Among men, occupational handling of oils while working with transformers or capacitors which contain polychlorinated biphenyls (PCB) was solicited. Unconditional logistic regression analyses were calculated, adjusting for several potential confounders. Analyses were stratified by sex. Two hundred and ninety-three cases (165 men, 128 women) and 3,198 control subjects (2,121 men, 1,077 women) were interviewed. Among women, no associations were observed with hormonal status variables, intake of hormonal therapy or intake of oral contraceptives. Men showed an increased risk with occupational exposure to transformer/capacitor oils (OR = 2.74; Bonferroni-corrected 99.3% CI 1.07-7.02). However, these results were based on few exposed subjects only. The results of this study do not support the hypothesis of a hormonal influence in the carcinogenesis of uveal melanoma. Our finding of a potentially increased risk with PCB-containing oils requires further research. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hormone replacement therapy, Case-control study, Eye melanoma, Multicentre study, PCB
in
Cancer Causes and Control
volume
21
issue
10
pages
1625 - 1634
publisher
Springer
external identifiers
  • wos:000281934800010
  • scopus:77956978528
ISSN
1573-7225
DOI
10.1007/s10552-010-9591-9
language
English
LU publication?
yes
id
aac17f23-6688-42dc-8b1e-fd5e47673e8b (old id 1728104)
date added to LUP
2016-04-01 11:08:11
date last changed
2025-04-04 14:45:30
@article{aac17f23-6688-42dc-8b1e-fd5e47673e8b,
  abstract     = {{Several studies suggest that hormonal mechanisms may be associated with the development of uveal melanoma. Therefore, the association between the risk of uveal melanoma and exposure to hormonal exposures was investigated in a case-control study from nine European countries. Incident cases of uveal melanoma were frequency-matched to population and hospital controls by country, age, and sex. Female subjects were asked about their reproductive history, use of menopausal hormone replacement therapy and oral contraceptives. Among men, occupational handling of oils while working with transformers or capacitors which contain polychlorinated biphenyls (PCB) was solicited. Unconditional logistic regression analyses were calculated, adjusting for several potential confounders. Analyses were stratified by sex. Two hundred and ninety-three cases (165 men, 128 women) and 3,198 control subjects (2,121 men, 1,077 women) were interviewed. Among women, no associations were observed with hormonal status variables, intake of hormonal therapy or intake of oral contraceptives. Men showed an increased risk with occupational exposure to transformer/capacitor oils (OR = 2.74; Bonferroni-corrected 99.3% CI 1.07-7.02). However, these results were based on few exposed subjects only. The results of this study do not support the hypothesis of a hormonal influence in the carcinogenesis of uveal melanoma. Our finding of a potentially increased risk with PCB-containing oils requires further research.}},
  author       = {{Behrens, Thomas and Kaerlev, Linda and Cree, Ian and Lutz, Jean-Michel and Afonso, Noemia and Eriksson, Mikael and Guenel, Pascal and Merletti, Franco and Morales-Suarez-Varela, Maria and Stengrevics, Aivars and Sabroe, Svend and Cyr, Diane and Llopis-Gonzalez, Agustin and Gorini, Giuseppe and Sharkova, Galina and Hardell, Lennart and Ahrens, Wolfgang}},
  issn         = {{1573-7225}},
  keywords     = {{Hormone replacement therapy; Case-control study; Eye melanoma; Multicentre study; PCB}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1625--1634}},
  publisher    = {{Springer}},
  series       = {{Cancer Causes and Control}},
  title        = {{Hormonal exposures and the risk of uveal melanoma}},
  url          = {{http://dx.doi.org/10.1007/s10552-010-9591-9}},
  doi          = {{10.1007/s10552-010-9591-9}},
  volume       = {{21}},
  year         = {{2010}},
}