Phenotypic protein profiling of different B cell sub-populations using antibody CD-microarrays
Ellmark, Peter LU
; Högerkorp, Carl-Magnus
LU
; Ek, Sara
LU
; Beelov, Larissa
; Berglund, Mattias
; Rosenquist, Richard
; Christopherson, Richard
and Borrebaeck, Carl
LU
(2008)
In Cancer Letters
265.
p.98-106
- Abstract
- Antibody microarrays enable extensive protein expression profiling, and provide a valuable complement to DNA microarray-based gene expression profiling. In this study, we used DotScan™ antibody microarrays that contain antibodies against 82 different cell surface antigens, to determine phenotypic protein expression profiles for human B cell sub-populations. We then demonstrated that the B cell protein profile can be used to delineate the relationship between normal B cells and malignant counterparts. Principle component analysis showed that the lymphomas did not cluster with the normal memory B cells or germinal centre B cells, but they did cluster with germinal centre founder cells and naïve B cells.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1028778
- author
- Ellmark, Peter
LU
; Högerkorp, Carl-Magnus
LU
; Ek, Sara
LU
; Beelov, Larissa
; Berglund, Mattias
; Rosenquist, Richard
; Christopherson, Richard
and Borrebaeck, Carl
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer Letters
- volume
- 265
- pages
- 98 - 106
- publisher
- Elsevier
- external identifiers
-
- pmid:18353541
- wos:000256730200010
- scopus:43449096332
- pmid:18353541
- ISSN
- 1872-7980
- DOI
- 10.1016/j.canlet.2008.02.006
- language
- English
- LU publication?
- yes
- id
- 173039bc-1900-4f72-b0f0-acff3001dfa1 (old id 1028778)
- date added to LUP
- 2016-04-01 13:26:11
- date last changed
- 2025-10-14 11:40:42
@article{173039bc-1900-4f72-b0f0-acff3001dfa1,
abstract = {{Antibody microarrays enable extensive protein expression profiling, and provide a valuable complement to DNA microarray-based gene expression profiling. In this study, we used DotScan™ antibody microarrays that contain antibodies against 82 different cell surface antigens, to determine phenotypic protein expression profiles for human B cell sub-populations. We then demonstrated that the B cell protein profile can be used to delineate the relationship between normal B cells and malignant counterparts. Principle component analysis showed that the lymphomas did not cluster with the normal memory B cells or germinal centre B cells, but they did cluster with germinal centre founder cells and naïve B cells.}},
author = {{Ellmark, Peter and Högerkorp, Carl-Magnus and Ek, Sara and Beelov, Larissa and Berglund, Mattias and Rosenquist, Richard and Christopherson, Richard and Borrebaeck, Carl}},
issn = {{1872-7980}},
language = {{eng}},
pages = {{98--106}},
publisher = {{Elsevier}},
series = {{Cancer Letters}},
title = {{Phenotypic protein profiling of different B cell sub-populations using antibody CD-microarrays}},
url = {{http://dx.doi.org/10.1016/j.canlet.2008.02.006}},
doi = {{10.1016/j.canlet.2008.02.006}},
volume = {{265}},
year = {{2008}},
}