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A Biophysical Model of Electrical Activity in Human β-Cells.

Pedersen, Morten Gram LU (2010) In Biophysical Journal 99(10). p.3200-3207
Abstract
Electrical activity in pancreatic β-cells plays a pivotal role in glucose-stimulated insulin secretion by coupling metabolism to calcium-triggered exocytosis. Mathematical models based on rodent data have helped in understanding the mechanisms underlying the electrophysiological patterns observed in laboratory animals. However, human β-cells differ in several aspects, and in particular in their electrophysiological characteristics, from rodent β-cells. Hence, from a clinical perspective and to obtain insight into the defects in insulin secretion relevant for diabetes mellitus, it is important to study human β-cells. This work presents the first mathematical model of electrical activity based entirely on published ion channel... (More)
Electrical activity in pancreatic β-cells plays a pivotal role in glucose-stimulated insulin secretion by coupling metabolism to calcium-triggered exocytosis. Mathematical models based on rodent data have helped in understanding the mechanisms underlying the electrophysiological patterns observed in laboratory animals. However, human β-cells differ in several aspects, and in particular in their electrophysiological characteristics, from rodent β-cells. Hence, from a clinical perspective and to obtain insight into the defects in insulin secretion relevant for diabetes mellitus, it is important to study human β-cells. This work presents the first mathematical model of electrical activity based entirely on published ion channel characteristics of human β-cells. The model reproduces satisfactorily a series of experimentally observed patterns in human β-cells, such as spiking and rapid bursting electrical activity, and their response to a range of ion channel antagonists. The possibility of Human Ether-a-Go-Go-related- and leak channels as drug targets for diabetes treatment is discussed based on model results. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biophysical Journal
volume
99
issue
10
pages
3200 - 3207
publisher
Cell Press
external identifiers
  • wos:000284438700013
  • pmid:21081067
  • scopus:78549279833
ISSN
1542-0086
DOI
10.1016/j.bpj.2010.09.004
language
English
LU publication?
yes
id
3042c162-f8db-45ae-a6e4-b3522114e31a (old id 1731929)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21081067?dopt=Abstract
date added to LUP
2010-12-01 12:36:35
date last changed
2018-07-15 03:08:45
@article{3042c162-f8db-45ae-a6e4-b3522114e31a,
  abstract     = {Electrical activity in pancreatic β-cells plays a pivotal role in glucose-stimulated insulin secretion by coupling metabolism to calcium-triggered exocytosis. Mathematical models based on rodent data have helped in understanding the mechanisms underlying the electrophysiological patterns observed in laboratory animals. However, human β-cells differ in several aspects, and in particular in their electrophysiological characteristics, from rodent β-cells. Hence, from a clinical perspective and to obtain insight into the defects in insulin secretion relevant for diabetes mellitus, it is important to study human β-cells. This work presents the first mathematical model of electrical activity based entirely on published ion channel characteristics of human β-cells. The model reproduces satisfactorily a series of experimentally observed patterns in human β-cells, such as spiking and rapid bursting electrical activity, and their response to a range of ion channel antagonists. The possibility of Human Ether-a-Go-Go-related- and leak channels as drug targets for diabetes treatment is discussed based on model results.},
  author       = {Pedersen, Morten Gram},
  issn         = {1542-0086},
  language     = {eng},
  number       = {10},
  pages        = {3200--3207},
  publisher    = {Cell Press},
  series       = {Biophysical Journal},
  title        = {A Biophysical Model of Electrical Activity in Human β-Cells.},
  url          = {http://dx.doi.org/10.1016/j.bpj.2010.09.004},
  volume       = {99},
  year         = {2010},
}