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Coagulation Systems of Invertebrates and Vertebrates and Their Roles in Innate Immunity: The Same Side of Two Coins?

Loof, Torsten LU ; Schmidt, Otto; Herwald, Heiko LU and Theopold, Ulrich (2011) In Journal of Innate Immunity Dec. p.34-40
Abstract
Bacterial infections represent a serious health care problem, and all multicellular organisms have developed defense mechanisms to eliminate pathogens that enter the host via different paths including wounds. Many invertebrates have an open circulatory system, and effective coagulation systems are in place to ensure fast and efficient closure of wounds. It was proposed early on that coagulation systems in invertebrates play a major role not only in sealing wounds but also in preventing systemic infections. More recent evidence suggests that vertebrates, too, rely on clotting as an immune effector mechanism. Here we discuss the evolution of clotting systems against the background of their versatile function in innate immunity.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Innate Immunity
volume
Dec
pages
34 - 40
publisher
Karger
external identifiers
  • wos:000285568700006
  • pmid:21051879
  • scopus:78650515757
ISSN
1662-811X
DOI
10.1159/000321641
language
English
LU publication?
yes
id
a139307e-8bd2-4805-bfe7-a651f411e0c8 (old id 1732311)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21051879?dopt=Abstract
date added to LUP
2010-12-01 10:33:22
date last changed
2017-11-05 04:42:25
@article{a139307e-8bd2-4805-bfe7-a651f411e0c8,
  abstract     = {Bacterial infections represent a serious health care problem, and all multicellular organisms have developed defense mechanisms to eliminate pathogens that enter the host via different paths including wounds. Many invertebrates have an open circulatory system, and effective coagulation systems are in place to ensure fast and efficient closure of wounds. It was proposed early on that coagulation systems in invertebrates play a major role not only in sealing wounds but also in preventing systemic infections. More recent evidence suggests that vertebrates, too, rely on clotting as an immune effector mechanism. Here we discuss the evolution of clotting systems against the background of their versatile function in innate immunity.},
  author       = {Loof, Torsten and Schmidt, Otto and Herwald, Heiko and Theopold, Ulrich},
  issn         = {1662-811X},
  language     = {eng},
  pages        = {34--40},
  publisher    = {Karger},
  series       = {Journal of Innate Immunity},
  title        = {Coagulation Systems of Invertebrates and Vertebrates and Their Roles in Innate Immunity: The Same Side of Two Coins?},
  url          = {http://dx.doi.org/10.1159/000321641},
  volume       = {Dec},
  year         = {2011},
}