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Prostate cancer diagnosed after prostate-specific antigen testing of men without clinical signs of the disease: A population-based study from the National Prostate Cancer Register of Sweden

Bratt, Ola LU ; Berglund, Anders; Adolfsson, Jan; Johansson, Jan-Erik; Tornblom, Magnus and Stattin, Par (2010) In Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00 44(6). p.384-390
Abstract
Objective. To investigate the effects of prostate-specific antigen (PSA) testing of men without clinical signs of prostate cancer on the incidence of prostate cancer in Sweden. Material and methods. Information on the cause of diagnosis, tumour characteristics and primary treatment for patients diagnosed with prostate cancer between January 1999 and December 2007 was extracted from the National Prostate Cancer Register of Sweden. This register includes data for 95% of Swedish prostate cancer cases. Results. The total age-standardized annual incidence of prostate cancer per 100 000 men increased from 187 in 1999 to 233 in 2004, but decreased thereafter to 196 in 2007. The incidence of asymptomatic cases also peaked in 2004 (at 62 per 100... (More)
Objective. To investigate the effects of prostate-specific antigen (PSA) testing of men without clinical signs of prostate cancer on the incidence of prostate cancer in Sweden. Material and methods. Information on the cause of diagnosis, tumour characteristics and primary treatment for patients diagnosed with prostate cancer between January 1999 and December 2007 was extracted from the National Prostate Cancer Register of Sweden. This register includes data for 95% of Swedish prostate cancer cases. Results. The total age-standardized annual incidence of prostate cancer per 100 000 men increased from 187 in 1999 to 233 in 2004, but decreased thereafter to 196 in 2007. The incidence of asymptomatic cases also peaked in 2004 (at 62 per 100 000 men), but varied six-fold between different counties in that year (16-98 per 100 000 men). Asymptomatic cases (n = 17 143) constituted 15% of all new cases in 2000 and 30% in 2007. Almost as many cases were diagnosed in stage T1c in men with symptoms, usually from the lower urinary tract. Together these two groups constituted 29% of all new cases in 2000 and 52% in 2007. It was estimated that at least one-third of all Swedish men aged 50-75 years had a PSA test between 2000 and 2007. Conclusions. Even though screening for prostate cancer is not recommended in Sweden, PSA testing of men without clinical signs of prostate cancer is common. The effects on the Swedish incidence of prostate cancer were similar to those reported from the USA. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prostate-specific antigen, prostate cancer, Epidemiology, incidence, screening
in
Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00
volume
44
issue
6
pages
384 - 390
publisher
Taylor & Francis
external identifiers
  • wos:000284316200003
  • scopus:78649308573
ISSN
0036-5599
DOI
10.3109/00365599.2010.498793
language
English
LU publication?
yes
id
efdd0dc1-e5c5-41be-ae3a-083f2263cc70 (old id 1752030)
date added to LUP
2011-01-04 08:05:25
date last changed
2018-05-29 10:31:33
@article{efdd0dc1-e5c5-41be-ae3a-083f2263cc70,
  abstract     = {Objective. To investigate the effects of prostate-specific antigen (PSA) testing of men without clinical signs of prostate cancer on the incidence of prostate cancer in Sweden. Material and methods. Information on the cause of diagnosis, tumour characteristics and primary treatment for patients diagnosed with prostate cancer between January 1999 and December 2007 was extracted from the National Prostate Cancer Register of Sweden. This register includes data for 95% of Swedish prostate cancer cases. Results. The total age-standardized annual incidence of prostate cancer per 100 000 men increased from 187 in 1999 to 233 in 2004, but decreased thereafter to 196 in 2007. The incidence of asymptomatic cases also peaked in 2004 (at 62 per 100 000 men), but varied six-fold between different counties in that year (16-98 per 100 000 men). Asymptomatic cases (n = 17 143) constituted 15% of all new cases in 2000 and 30% in 2007. Almost as many cases were diagnosed in stage T1c in men with symptoms, usually from the lower urinary tract. Together these two groups constituted 29% of all new cases in 2000 and 52% in 2007. It was estimated that at least one-third of all Swedish men aged 50-75 years had a PSA test between 2000 and 2007. Conclusions. Even though screening for prostate cancer is not recommended in Sweden, PSA testing of men without clinical signs of prostate cancer is common. The effects on the Swedish incidence of prostate cancer were similar to those reported from the USA.},
  author       = {Bratt, Ola and Berglund, Anders and Adolfsson, Jan and Johansson, Jan-Erik and Tornblom, Magnus and Stattin, Par},
  issn         = {0036-5599},
  keyword      = {prostate-specific antigen,prostate cancer,Epidemiology,incidence,screening},
  language     = {eng},
  number       = {6},
  pages        = {384--390},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00},
  title        = {Prostate cancer diagnosed after prostate-specific antigen testing of men without clinical signs of the disease: A population-based study from the National Prostate Cancer Register of Sweden},
  url          = {http://dx.doi.org/10.3109/00365599.2010.498793},
  volume       = {44},
  year         = {2010},
}