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Occupation and occupational exposure to endocrine disrupting chemicals in male breast cancer: a case-control study in Europe

Villeneuve, Sara; Cyr, Diane; Lynge, Elsebeth; Orsi, Laurent; Sabroe, Svend; Merletti, Franco; Gorini, Giuseppe; Morales-Suarez-Varela, Maria; Ahrens, Wolfgang and Baumgardt-Elms, Cornelia, et al. (2010) In Occupational and Environmental Medicine1994-01-01+01:00 67(12). p.837-844
Abstract
Objectives Male breast cancer is a rare disease of largely unknown aetiology. In addition to genetic and hormone-related risk factors, a large number of environmental chemicals are suspected of playing a role in breast cancer. The identification of occupations or occupational exposures associated with an increased incidence of breast cancer in men may help to identify mammary carcinogens in the environment. Methods Occupational risk factors for male breast cancer were investigated in a multi-centre case-control study conducted in eight European countries which included 104 cases and 1901 controls. Lifetime work history was obtained during in-person interviews. Occupational exposures to endocrine disrupting chemicals (alkylphenolic... (More)
Objectives Male breast cancer is a rare disease of largely unknown aetiology. In addition to genetic and hormone-related risk factors, a large number of environmental chemicals are suspected of playing a role in breast cancer. The identification of occupations or occupational exposures associated with an increased incidence of breast cancer in men may help to identify mammary carcinogens in the environment. Methods Occupational risk factors for male breast cancer were investigated in a multi-centre case-control study conducted in eight European countries which included 104 cases and 1901 controls. Lifetime work history was obtained during in-person interviews. Occupational exposures to endocrine disrupting chemicals (alkylphenolic compounds, phthalates, polychlorinated biphenyls and dioxins) were assessed on a case-by-case basis using expert judgement. Results Male breast cancer incidence was particularly increased in motor vehicle mechanics (OR 2.1, 95% CI 1.0 to 4.4) with a dose-effect relationship with duration of employment. It was also increased in paper makers and painters, forestry and logging workers, health and social workers, and furniture manufacture workers. The OR for exposure to alkylphenolic compounds above the median was 3.8 (95% CI 1.5 to 9.5). This association persisted after adjustment for occupational exposures to other environmental oestrogens. Conclusion These findings suggest that some environmental chemicals are possible mammary carcinogens. Petrol, organic petroleum solvents or polycyclic aromatic hydrocarbons are suspect because of the consistent elevated risk of male breast cancer observed in motor vehicle mechanics. Endocrine disruptors such as alkylphenolic compounds may play a role in breast cancer. (Less)
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published
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Occupational and Environmental Medicine1994-01-01+01:00
volume
67
issue
12
pages
837 - 844
publisher
BMJ Publishing Group
external identifiers
  • wos:000284148600008
  • scopus:78649644144
ISSN
1470-7926
DOI
10.1136/oem.2009.052175
language
English
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yes
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9fc33cc7-2dbf-4d4b-a023-3c521d63aa12 (old id 1753034)
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2011-01-04 08:03:46
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2018-05-29 12:00:06
@article{9fc33cc7-2dbf-4d4b-a023-3c521d63aa12,
  abstract     = {Objectives Male breast cancer is a rare disease of largely unknown aetiology. In addition to genetic and hormone-related risk factors, a large number of environmental chemicals are suspected of playing a role in breast cancer. The identification of occupations or occupational exposures associated with an increased incidence of breast cancer in men may help to identify mammary carcinogens in the environment. Methods Occupational risk factors for male breast cancer were investigated in a multi-centre case-control study conducted in eight European countries which included 104 cases and 1901 controls. Lifetime work history was obtained during in-person interviews. Occupational exposures to endocrine disrupting chemicals (alkylphenolic compounds, phthalates, polychlorinated biphenyls and dioxins) were assessed on a case-by-case basis using expert judgement. Results Male breast cancer incidence was particularly increased in motor vehicle mechanics (OR 2.1, 95% CI 1.0 to 4.4) with a dose-effect relationship with duration of employment. It was also increased in paper makers and painters, forestry and logging workers, health and social workers, and furniture manufacture workers. The OR for exposure to alkylphenolic compounds above the median was 3.8 (95% CI 1.5 to 9.5). This association persisted after adjustment for occupational exposures to other environmental oestrogens. Conclusion These findings suggest that some environmental chemicals are possible mammary carcinogens. Petrol, organic petroleum solvents or polycyclic aromatic hydrocarbons are suspect because of the consistent elevated risk of male breast cancer observed in motor vehicle mechanics. Endocrine disruptors such as alkylphenolic compounds may play a role in breast cancer.},
  author       = {Villeneuve, Sara and Cyr, Diane and Lynge, Elsebeth and Orsi, Laurent and Sabroe, Svend and Merletti, Franco and Gorini, Giuseppe and Morales-Suarez-Varela, Maria and Ahrens, Wolfgang and Baumgardt-Elms, Cornelia and Kaerlev, Linda and Eriksson, Mikael and Hardell, Lennart and Fevotte, Joelle and Guenel, Pascal},
  issn         = {1470-7926},
  language     = {eng},
  number       = {12},
  pages        = {837--844},
  publisher    = {BMJ Publishing Group},
  series       = {Occupational and Environmental Medicine1994-01-01+01:00},
  title        = {Occupation and occupational exposure to endocrine disrupting chemicals in male breast cancer: a case-control study in Europe},
  url          = {http://dx.doi.org/10.1136/oem.2009.052175},
  volume       = {67},
  year         = {2010},
}