Advanced

Effects of Selenium Status and Polymorphisms in Selenoprotein Genes on Prostate Cancer Risk in a Prospective Study of European Men

Steinbrecher, Astrid; Meplan, Catherine; Hesketh, John; Schomburg, Lutz; Endermann, Tobias; Jansen, Eugene; Åkesson, Björn LU ; Rohrmann, Sabine and Linseisen, Jakob (2010) In Cancer Epidemiology Biomarkers & Prevention 19(11). p.2958-2968
Abstract
Background: Evidence for an association between selenium status and prostate cancer risk is still inconclusive. Anticarcinogenic effects of selenium are supposedly mediated through cellular protective and redox properties of selenoenzymes in vivo. We evaluated the association between serum selenium status and prostate cancer risk in a population with relative low selenium concentrations considering effect modification by genetic variants in selenoprotein genes. Materials and Methods: A case-control study of 248 incident prostate cancer cases and 492 matched controls was nested within the EPIC-Heidelberg cohort. Baseline blood samples were analyzed for serum selenium and selenoprotein P concentrations and glutathione peroxidase activity.... (More)
Background: Evidence for an association between selenium status and prostate cancer risk is still inconclusive. Anticarcinogenic effects of selenium are supposedly mediated through cellular protective and redox properties of selenoenzymes in vivo. We evaluated the association between serum selenium status and prostate cancer risk in a population with relative low selenium concentrations considering effect modification by genetic variants in selenoprotein genes. Materials and Methods: A case-control study of 248 incident prostate cancer cases and 492 matched controls was nested within the EPIC-Heidelberg cohort. Baseline blood samples were analyzed for serum selenium and selenoprotein P concentrations and glutathione peroxidase activity. Genotyping was carried out for SEP15 (rs5859, rs540049), SEPP1 (rs3877899, rs7579), GPX1 (rs1050450), and GPX4 (rs713041). Conditional logistic regression was used to calculate adjusted odds ratios (OR) and 95% confidence intervals (95% CI). Results: The OR for prostate cancer was 0.89 (95% CI, 0.79-1.01) per 10 mu g/L increase of serum selenium concentration. This association was modified by rs1050450 (C>T) in GPX1 (P-interaction = 0.03), with carriers of one or two T alleles having a significantly reduced OR of 0.87 (95% CI, 0.76-0.99). Furthermore, there was an association between rs7579 genotype in SEPP1 and prostate cancer risk (OR, 1.72; 95% CI, 0.99-2.98). Conclusions: Our results support a role of selenium and polymorphisms in selenoenzymes in prostate cancer etiology, which warrants confirmation in future studies. Impact: These findings might help to explain biological effects of selenium in prostate cancer development in order to overcome inconsistencies arising from former studies. Cancer Epidemiol Biomarkers Prev; 19(11); 2958-68. (C) 2010 AACR. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Epidemiology Biomarkers & Prevention
volume
19
issue
11
pages
2958 - 2968
publisher
American Association for Cancer Research
external identifiers
  • wos:000283991600030
  • scopus:78549266895
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-10-0364
language
English
LU publication?
yes
id
9bbeb3ba-7c68-4d21-bd6d-1ed5e9d77af2 (old id 1753416)
date added to LUP
2010-12-29 13:01:31
date last changed
2018-05-29 10:59:28
@article{9bbeb3ba-7c68-4d21-bd6d-1ed5e9d77af2,
  abstract     = {Background: Evidence for an association between selenium status and prostate cancer risk is still inconclusive. Anticarcinogenic effects of selenium are supposedly mediated through cellular protective and redox properties of selenoenzymes in vivo. We evaluated the association between serum selenium status and prostate cancer risk in a population with relative low selenium concentrations considering effect modification by genetic variants in selenoprotein genes. Materials and Methods: A case-control study of 248 incident prostate cancer cases and 492 matched controls was nested within the EPIC-Heidelberg cohort. Baseline blood samples were analyzed for serum selenium and selenoprotein P concentrations and glutathione peroxidase activity. Genotyping was carried out for SEP15 (rs5859, rs540049), SEPP1 (rs3877899, rs7579), GPX1 (rs1050450), and GPX4 (rs713041). Conditional logistic regression was used to calculate adjusted odds ratios (OR) and 95% confidence intervals (95% CI). Results: The OR for prostate cancer was 0.89 (95% CI, 0.79-1.01) per 10 mu g/L increase of serum selenium concentration. This association was modified by rs1050450 (C>T) in GPX1 (P-interaction = 0.03), with carriers of one or two T alleles having a significantly reduced OR of 0.87 (95% CI, 0.76-0.99). Furthermore, there was an association between rs7579 genotype in SEPP1 and prostate cancer risk (OR, 1.72; 95% CI, 0.99-2.98). Conclusions: Our results support a role of selenium and polymorphisms in selenoenzymes in prostate cancer etiology, which warrants confirmation in future studies. Impact: These findings might help to explain biological effects of selenium in prostate cancer development in order to overcome inconsistencies arising from former studies. Cancer Epidemiol Biomarkers Prev; 19(11); 2958-68. (C) 2010 AACR.},
  author       = {Steinbrecher, Astrid and Meplan, Catherine and Hesketh, John and Schomburg, Lutz and Endermann, Tobias and Jansen, Eugene and Åkesson, Björn and Rohrmann, Sabine and Linseisen, Jakob},
  issn         = {1538-7755},
  language     = {eng},
  number       = {11},
  pages        = {2958--2968},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Effects of Selenium Status and Polymorphisms in Selenoprotein Genes on Prostate Cancer Risk in a Prospective Study of European Men},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-10-0364},
  volume       = {19},
  year         = {2010},
}