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Immunochemical Staining of MT2-MMP Correlates Positively to Angiogenesis of Human Esophageal Cancer

Chen, Lujun; Di, Dongmei; Luo, Guanghua; Zheng, Lu; Tan, Yan; Zhang, Xiaoying and Xu, Ning LU (2010) In Anticancer Research 30(10). p.4363-4368
Abstract
Matrix metalloproteinases (MMPs) play an important role in the pathological processes of degradation of extracellular matrix and destruction of basement membrane, which leads to tumor invasion and metastasis. In the present study, we investigated membrane-type 2 MMP (MT2-MMP) expression pattern in esophageal cancer tissues collected from 103 patients, and explored MT2-MMP expression pattern in correlation to patients' clinicopathological features, intratumoral angiogenesis and postoperative prognoses. The intensity of immunochemical staining of MT2-MMP was significantly positively correlated to the intratumoral angiogenesis of esophageal cancer tissues. Positive MT2-MMP immunoreactions were found in 85.4% of total tumor sections, whereas... (More)
Matrix metalloproteinases (MMPs) play an important role in the pathological processes of degradation of extracellular matrix and destruction of basement membrane, which leads to tumor invasion and metastasis. In the present study, we investigated membrane-type 2 MMP (MT2-MMP) expression pattern in esophageal cancer tissues collected from 103 patients, and explored MT2-MMP expression pattern in correlation to patients' clinicopathological features, intratumoral angiogenesis and postoperative prognoses. The intensity of immunochemical staining of MT2-MMP was significantly positively correlated to the intratumoral angiogenesis of esophageal cancer tissues. Positive MT2-MMP immunoreactions were found in 85.4% of total tumor sections, whereas none or very weak MT2-MMP staining occurred in normal esophageal tissues. In addition, MT2-MMP immunochemical intensities were significantly correlated to tumor size, but not to patient's gender, age, invasion depth, lymph node metastasis and distant metastasis. Moreover, MT2-MMP levels could not be applied for predicting patients' survival rate although the H-score cut-off value showed the overall survival rate of patients with low MT2-MMP protein level to be better than those with high MT2-MMP protein level. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
MT2-MMP, intratumoral angiogenesis, esophageal cancer
in
Anticancer Research
volume
30
issue
10
pages
4363 - 4368
publisher
International Institute of Cancer Research
external identifiers
  • wos:000283914400070
  • scopus:78650244557
ISSN
1791-7530
language
English
LU publication?
yes
id
bdb258ff-6cc1-48e4-8077-6bdbf630455d (old id 1753481)
alternative location
http://ar.iiarjournals.org/content/30/10/4363
date added to LUP
2010-12-29 11:29:08
date last changed
2018-05-29 10:10:46
@article{bdb258ff-6cc1-48e4-8077-6bdbf630455d,
  abstract     = {Matrix metalloproteinases (MMPs) play an important role in the pathological processes of degradation of extracellular matrix and destruction of basement membrane, which leads to tumor invasion and metastasis. In the present study, we investigated membrane-type 2 MMP (MT2-MMP) expression pattern in esophageal cancer tissues collected from 103 patients, and explored MT2-MMP expression pattern in correlation to patients' clinicopathological features, intratumoral angiogenesis and postoperative prognoses. The intensity of immunochemical staining of MT2-MMP was significantly positively correlated to the intratumoral angiogenesis of esophageal cancer tissues. Positive MT2-MMP immunoreactions were found in 85.4% of total tumor sections, whereas none or very weak MT2-MMP staining occurred in normal esophageal tissues. In addition, MT2-MMP immunochemical intensities were significantly correlated to tumor size, but not to patient's gender, age, invasion depth, lymph node metastasis and distant metastasis. Moreover, MT2-MMP levels could not be applied for predicting patients' survival rate although the H-score cut-off value showed the overall survival rate of patients with low MT2-MMP protein level to be better than those with high MT2-MMP protein level.},
  author       = {Chen, Lujun and Di, Dongmei and Luo, Guanghua and Zheng, Lu and Tan, Yan and Zhang, Xiaoying and Xu, Ning},
  issn         = {1791-7530},
  keyword      = {MT2-MMP,intratumoral angiogenesis,esophageal cancer},
  language     = {eng},
  number       = {10},
  pages        = {4363--4368},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer Research},
  title        = {Immunochemical Staining of MT2-MMP Correlates Positively to Angiogenesis of Human Esophageal Cancer},
  volume       = {30},
  year         = {2010},
}