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Insight into molecular imprinting in precipitation polymerization systems using solution NMR and dynamic light scattering.

Long, Yuanyuan LU ; Philip, JosephYN LU ; Schillén, Karin LU ; Liu, Feng and Ye, Lei LU (2011) In Journal of Molecular Recognition 24(4). p.619-630
Abstract
Molecular imprinting is a powerful synthetic technique for generating template-defined binding sites in cross-linked polymers. One scientific challenge in molecular imprinting research is to understand the intermolecular interactions leading to molecular complexation and the process of binding site formation during polymerization. In this work, we present a novel method for studying the molecular imprinting process in precipitation polymerization systems. This method employs solution (1)H NMR and dynamic light scattering (DLS) to investigate the association of template molecules with colloidal particles and the dynamic process of particle growth. Under precipitation polymerization conditions, the colloidal particles formed did not... (More)
Molecular imprinting is a powerful synthetic technique for generating template-defined binding sites in cross-linked polymers. One scientific challenge in molecular imprinting research is to understand the intermolecular interactions leading to molecular complexation and the process of binding site formation during polymerization. In this work, we present a novel method for studying the molecular imprinting process in precipitation polymerization systems. This method employs solution (1)H NMR and dynamic light scattering (DLS) to investigate the association of template molecules with colloidal particles and the dynamic process of particle growth. Under precipitation polymerization conditions, the colloidal particles formed did not interfere with NMR signals from the soluble components, allowing unreacted monomers and free template to be easily quantified. To examine the process of particle nucleation and growth, DLS was used to measure the hydrodynamic particle size at different reaction times. To corroborate the interpretation of the NMR and DLS results, imprinted nanoparticles were collected at different reaction times and their binding characteristics were evaluated using radioligand-binding analysis. Our experimental results provide new insights into the molecular imprinting process that will be useful in the development of new imprinted nanoparticles. Copyright © 2010 John Wiley & Sons, Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Molecular Recognition
volume
24
issue
4
pages
619 - 630
publisher
John Wiley & Sons
external identifiers
  • wos:000289786300010
  • pmid:21161950
  • scopus:79953782253
ISSN
1099-1352
DOI
10.1002/jmr.1097
language
English
LU publication?
yes
id
9381160c-1f11-4533-ad3e-e771b951caa2 (old id 1756259)
date added to LUP
2011-01-11 14:41:40
date last changed
2017-09-24 03:13:55
@article{9381160c-1f11-4533-ad3e-e771b951caa2,
  abstract     = {Molecular imprinting is a powerful synthetic technique for generating template-defined binding sites in cross-linked polymers. One scientific challenge in molecular imprinting research is to understand the intermolecular interactions leading to molecular complexation and the process of binding site formation during polymerization. In this work, we present a novel method for studying the molecular imprinting process in precipitation polymerization systems. This method employs solution (1)H NMR and dynamic light scattering (DLS) to investigate the association of template molecules with colloidal particles and the dynamic process of particle growth. Under precipitation polymerization conditions, the colloidal particles formed did not interfere with NMR signals from the soluble components, allowing unreacted monomers and free template to be easily quantified. To examine the process of particle nucleation and growth, DLS was used to measure the hydrodynamic particle size at different reaction times. To corroborate the interpretation of the NMR and DLS results, imprinted nanoparticles were collected at different reaction times and their binding characteristics were evaluated using radioligand-binding analysis. Our experimental results provide new insights into the molecular imprinting process that will be useful in the development of new imprinted nanoparticles. Copyright © 2010 John Wiley & Sons, Ltd.},
  author       = {Long, Yuanyuan and Philip, JosephYN and Schillén, Karin and Liu, Feng and Ye, Lei},
  issn         = {1099-1352},
  language     = {eng},
  number       = {4},
  pages        = {619--630},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Molecular Recognition},
  title        = {Insight into molecular imprinting in precipitation polymerization systems using solution NMR and dynamic light scattering.},
  url          = {http://dx.doi.org/10.1002/jmr.1097},
  volume       = {24},
  year         = {2011},
}