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Gene-Lifestyle and Gene-Pharmacotherpy Interactions in Obesity and Its Cardiovascular Consequences.

Franks, Paul LU and Poveda, Alaitz LU (2011) In Current Vascular Pharmacology 9(4). p.401-456
Abstract
Obesity is a highly prevalent complex trait that raises the risk of other chronic diseases such as type 2 diabetes, certain cancers, sleep apnea, and cardiovascular disease, and shortens lifespan. Clinical intervention studies focused on weight loss and epidemiological studies of obesity indicate that genetic variation may modify the relationship between lifestyle behaviors and weight loss or weight gain. Similar observations have also emerged from pharmacogenetic studies. The literature includes several reports from these studies, but few examples of interactions have been adequately replicated. In this review we introduce the topics of population genetics research and gene x environment interaction. We also provide a systematic review of... (More)
Obesity is a highly prevalent complex trait that raises the risk of other chronic diseases such as type 2 diabetes, certain cancers, sleep apnea, and cardiovascular disease, and shortens lifespan. Clinical intervention studies focused on weight loss and epidemiological studies of obesity indicate that genetic variation may modify the relationship between lifestyle behaviors and weight loss or weight gain. Similar observations have also emerged from pharmacogenetic studies. The literature includes several reports from these studies, but few examples of interactions have been adequately replicated. In this review we introduce the topics of population genetics research and gene x environment interaction. We also provide a systematic review of the published literature on gene x lifestyle (physical activity and dietary factors) and gene x drug interactions in relation to obesity. Finally, we overview the scope and findings from these studies and discuss some of their strengths and limitations. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
gene x drug interaction, Genetic, gene x lifestyle interaction, nutrition, nutriogenomics, obesity, pharmacogenetics, physical activity
in
Current Vascular Pharmacology
volume
9
issue
4
pages
401 - 456
publisher
Bentham Science Publishers
external identifiers
  • wos:000293216900003
  • pmid:21143160
ISSN
1570-1611
language
English
LU publication?
yes
id
ad06ef2a-8497-436c-8391-058720402ee3 (old id 1756577)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21143160?dopt=Abstract
date added to LUP
2011-01-03 14:48:09
date last changed
2016-04-15 14:47:58
@article{ad06ef2a-8497-436c-8391-058720402ee3,
  abstract     = {Obesity is a highly prevalent complex trait that raises the risk of other chronic diseases such as type 2 diabetes, certain cancers, sleep apnea, and cardiovascular disease, and shortens lifespan. Clinical intervention studies focused on weight loss and epidemiological studies of obesity indicate that genetic variation may modify the relationship between lifestyle behaviors and weight loss or weight gain. Similar observations have also emerged from pharmacogenetic studies. The literature includes several reports from these studies, but few examples of interactions have been adequately replicated. In this review we introduce the topics of population genetics research and gene x environment interaction. We also provide a systematic review of the published literature on gene x lifestyle (physical activity and dietary factors) and gene x drug interactions in relation to obesity. Finally, we overview the scope and findings from these studies and discuss some of their strengths and limitations.},
  author       = {Franks, Paul and Poveda, Alaitz},
  issn         = {1570-1611},
  keyword      = {gene x drug interaction,Genetic,gene x lifestyle interaction,nutrition,nutriogenomics,obesity,pharmacogenetics,physical activity},
  language     = {eng},
  number       = {4},
  pages        = {401--456},
  publisher    = {Bentham Science Publishers},
  series       = {Current Vascular Pharmacology},
  title        = {Gene-Lifestyle and Gene-Pharmacotherpy Interactions in Obesity and Its Cardiovascular Consequences.},
  volume       = {9},
  year         = {2011},
}