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Genetics of Type 2 Diabetes.

Ahlqvist, Emma LU ; Ahluwalia, Tarunveer Singh and Groop, Leif LU (2011) In Clinical Chemistry 57. p.241-254
Abstract
BACKGROUND: Type 2 diabetes (T2D) is a complex disorder that is affected by multiple genetic and environmental factors. Extensive efforts have been made to identify the disease-affecting genes to better understand the disease pathogenesis, find new targets for clinical therapy, and allow prediction of disease. CONTENT: Our knowledge about the genes involved in disease pathogenesis has increased substantially in recent years, thanks to genome-wide association studies and international collaborations joining efforts to collect the huge numbers of individuals needed to study complex diseases on a population level. We have summarized what we have learned so far about the genes that affect T2D risk and their functions. Although more than 40... (More)
BACKGROUND: Type 2 diabetes (T2D) is a complex disorder that is affected by multiple genetic and environmental factors. Extensive efforts have been made to identify the disease-affecting genes to better understand the disease pathogenesis, find new targets for clinical therapy, and allow prediction of disease. CONTENT: Our knowledge about the genes involved in disease pathogenesis has increased substantially in recent years, thanks to genome-wide association studies and international collaborations joining efforts to collect the huge numbers of individuals needed to study complex diseases on a population level. We have summarized what we have learned so far about the genes that affect T2D risk and their functions. Although more than 40 loci associated with T2D or glycemic traits have been reported and reproduced, only a minor part of the genetic component of the disease have been explained, and the causative variants and affected genes are unknown for many of the loci. SUMMARY: Great advances have recently occurred in our understanding of the genetics of T2D, but much remains to be learned about the disease etiology. The genetics of T2D has so far been driven by technology, and we now hope that next-generation sequencing will provide important information on rare variants with stronger effects. Even when variants are known, however, great effort will be required to discover how they affect disease risk. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Chemistry
volume
57
pages
241 - 254
publisher
American Association for Clinical Chemistry
external identifiers
  • wos:000286653000016
  • pmid:21119033
  • scopus:79551497900
ISSN
0009-9147
DOI
10.1373/clinchem.2010.157016
language
English
LU publication?
yes
id
0505e4f6-5550-4c5f-907a-164e004268b8 (old id 1756906)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21119033?dopt=Abstract
date added to LUP
2011-01-03 11:30:39
date last changed
2017-09-03 04:51:00
@article{0505e4f6-5550-4c5f-907a-164e004268b8,
  abstract     = {BACKGROUND: Type 2 diabetes (T2D) is a complex disorder that is affected by multiple genetic and environmental factors. Extensive efforts have been made to identify the disease-affecting genes to better understand the disease pathogenesis, find new targets for clinical therapy, and allow prediction of disease. CONTENT: Our knowledge about the genes involved in disease pathogenesis has increased substantially in recent years, thanks to genome-wide association studies and international collaborations joining efforts to collect the huge numbers of individuals needed to study complex diseases on a population level. We have summarized what we have learned so far about the genes that affect T2D risk and their functions. Although more than 40 loci associated with T2D or glycemic traits have been reported and reproduced, only a minor part of the genetic component of the disease have been explained, and the causative variants and affected genes are unknown for many of the loci. SUMMARY: Great advances have recently occurred in our understanding of the genetics of T2D, but much remains to be learned about the disease etiology. The genetics of T2D has so far been driven by technology, and we now hope that next-generation sequencing will provide important information on rare variants with stronger effects. Even when variants are known, however, great effort will be required to discover how they affect disease risk.},
  author       = {Ahlqvist, Emma and Ahluwalia, Tarunveer Singh and Groop, Leif},
  issn         = {0009-9147},
  language     = {eng},
  pages        = {241--254},
  publisher    = {American Association for Clinical Chemistry},
  series       = {Clinical Chemistry},
  title        = {Genetics of Type 2 Diabetes.},
  url          = {http://dx.doi.org/10.1373/clinchem.2010.157016},
  volume       = {57},
  year         = {2011},
}