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The ‘autoimmunome’ of centenarians

Carrera-Bastos, Pedro LU ; Plaza-Florido, Abel ; Santos-Lozano, Alejandro ; Borba, Vânia ; Rodríguez-Romo, Gabriel ; García-Chico, Celia ; Lista, Simone ; Saco-Ledo, Gonzalo ; Emanuele, Enzo and Shoenfeld, Yehuda , et al. (2025) In Journal of Translational Autoimmunity 11.
Abstract

Objective: To identify signature proteins potentially linked to resistance to autoimmunity in the blood of centenarians. Methods: We conducted in silico data mining of previously published proteomic results using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and PHENOPEDIA databases. Results: Sixteen autoimmune disease-related proteins were identified within the proteomic signatures of centenarians. Albumin was the most connected hub protein, notably elevated in centenarians compared to younger controls, suggesting a protective role. Eight of the identified autoimmunity-related proteins—ADIPOQ, C1S, C5, C7, C9, CFD, MASP1, and SERPING1—were associated with the complement system. Conclusion: Elevated albumin... (More)

Objective: To identify signature proteins potentially linked to resistance to autoimmunity in the blood of centenarians. Methods: We conducted in silico data mining of previously published proteomic results using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and PHENOPEDIA databases. Results: Sixteen autoimmune disease-related proteins were identified within the proteomic signatures of centenarians. Albumin was the most connected hub protein, notably elevated in centenarians compared to younger controls, suggesting a protective role. Eight of the identified autoimmunity-related proteins—ADIPOQ, C1S, C5, C7, C9, CFD, MASP1, and SERPING1—were associated with the complement system. Conclusion: Elevated albumin levels and a prominent complement system presence in centenarians' blood proteome may contribute to resistance to autoimmunity, highlighting potential protective mechanisms against autoimmune diseases in extreme longevity.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aging, Autoimmunity, Centenarians, Complement system, Longevity, Protein-protein interaction
in
Journal of Translational Autoimmunity
volume
11
article number
100295
publisher
Elsevier
external identifiers
  • scopus:105007552517
  • pmid:40546301
ISSN
2589-9090
DOI
10.1016/j.jtauto.2025.100295
language
English
LU publication?
yes
id
17667bc0-a2ca-44b5-8bdb-0220ca932937
date added to LUP
2025-10-28 13:26:57
date last changed
2025-10-29 03:00:03
@article{17667bc0-a2ca-44b5-8bdb-0220ca932937,
  abstract     = {{<p>Objective: To identify signature proteins potentially linked to resistance to autoimmunity in the blood of centenarians. Methods: We conducted in silico data mining of previously published proteomic results using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and PHENOPEDIA databases. Results: Sixteen autoimmune disease-related proteins were identified within the proteomic signatures of centenarians. Albumin was the most connected hub protein, notably elevated in centenarians compared to younger controls, suggesting a protective role. Eight of the identified autoimmunity-related proteins—ADIPOQ, C1S, C5, C7, C9, CFD, MASP1, and SERPING1—were associated with the complement system. Conclusion: Elevated albumin levels and a prominent complement system presence in centenarians' blood proteome may contribute to resistance to autoimmunity, highlighting potential protective mechanisms against autoimmune diseases in extreme longevity.</p>}},
  author       = {{Carrera-Bastos, Pedro and Plaza-Florido, Abel and Santos-Lozano, Alejandro and Borba, Vânia and Rodríguez-Romo, Gabriel and García-Chico, Celia and Lista, Simone and Saco-Ledo, Gonzalo and Emanuele, Enzo and Shoenfeld, Yehuda and Lucia, Alejandro}},
  issn         = {{2589-9090}},
  keywords     = {{Aging; Autoimmunity; Centenarians; Complement system; Longevity; Protein-protein interaction}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Translational Autoimmunity}},
  title        = {{The ‘autoimmunome’ of centenarians}},
  url          = {{http://dx.doi.org/10.1016/j.jtauto.2025.100295}},
  doi          = {{10.1016/j.jtauto.2025.100295}},
  volume       = {{11}},
  year         = {{2025}},
}