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Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection

Svensson Frej, Marcus LU ; Bell, L.; Little, M. C.; deSchoolmeester, M.; Locksley, R. M. and Else, K. J. (2011) In Parasite Immunology 33(1). p.1-11
Abstract
P>Eosinophils have recently been demonstrated capable of localizing to lymph nodes that drain mucosal surfaces, in particular during T helper 2 (Th2) responses. Resistance of mice to infection with the gastrointestinal nematode Trichuris muris depends critically on mounting of a Th2 response and represents a useful model system to investigate Th2 responses. Following infection of resistant BALB/c mice with T. muris, we observed accumulation of eosinophils in intestine-draining mesenteric lymph nodes (MLNs). The accumulation of MLN eosinophils was initiated during the second week of infection and peaked during worm expulsion. In contrast, we detected a comparably late and modest increase in eosinophil numbers in the MLNs of infected... (More)
P>Eosinophils have recently been demonstrated capable of localizing to lymph nodes that drain mucosal surfaces, in particular during T helper 2 (Th2) responses. Resistance of mice to infection with the gastrointestinal nematode Trichuris muris depends critically on mounting of a Th2 response and represents a useful model system to investigate Th2 responses. Following infection of resistant BALB/c mice with T. muris, we observed accumulation of eosinophils in intestine-draining mesenteric lymph nodes (MLNs). The accumulation of MLN eosinophils was initiated during the second week of infection and peaked during worm expulsion. In contrast, we detected a comparably late and modest increase in eosinophil numbers in the MLNs of infected susceptible AKR mice. MLN eosinophils localized preferentially to the medullary region of the lymph node, displayed an activated phenotype and contributed to the interleukin-4 (IL-4) response in the MLN. Despite this, mice genetically deficient in eosinophils efficiently generated IL-4-expressing CD4+ T cells, produced Th2 cytokines and mediated worm expulsion during primary T. muris infection. Thus, IL-4-expressing eosinophils accumulate in MLNs of T. muris-infected BALB/c mice but are dispensable for worm expulsion and generation of Th2 responses, suggesting a distinct or subtle role of MLN eosinophils in the immune response to T. muris infection. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Trichuris, mesenteric lymph nodes, large intestine, eosinophils, IL-4, muris
in
Parasite Immunology
volume
33
issue
1
pages
1 - 11
publisher
Wiley-Blackwell
external identifiers
  • wos:000285306700001
  • scopus:78650050022
ISSN
1365-3024
DOI
10.1111/j.1365-3024.2010.01246.x
language
English
LU publication?
no
id
d1bae85a-50ee-41a5-b867-a200a7198bbc (old id 1773837)
date added to LUP
2011-02-01 10:36:06
date last changed
2017-10-01 03:05:57
@article{d1bae85a-50ee-41a5-b867-a200a7198bbc,
  abstract     = {P>Eosinophils have recently been demonstrated capable of localizing to lymph nodes that drain mucosal surfaces, in particular during T helper 2 (Th2) responses. Resistance of mice to infection with the gastrointestinal nematode Trichuris muris depends critically on mounting of a Th2 response and represents a useful model system to investigate Th2 responses. Following infection of resistant BALB/c mice with T. muris, we observed accumulation of eosinophils in intestine-draining mesenteric lymph nodes (MLNs). The accumulation of MLN eosinophils was initiated during the second week of infection and peaked during worm expulsion. In contrast, we detected a comparably late and modest increase in eosinophil numbers in the MLNs of infected susceptible AKR mice. MLN eosinophils localized preferentially to the medullary region of the lymph node, displayed an activated phenotype and contributed to the interleukin-4 (IL-4) response in the MLN. Despite this, mice genetically deficient in eosinophils efficiently generated IL-4-expressing CD4+ T cells, produced Th2 cytokines and mediated worm expulsion during primary T. muris infection. Thus, IL-4-expressing eosinophils accumulate in MLNs of T. muris-infected BALB/c mice but are dispensable for worm expulsion and generation of Th2 responses, suggesting a distinct or subtle role of MLN eosinophils in the immune response to T. muris infection.},
  author       = {Svensson Frej, Marcus and Bell, L. and Little, M. C. and deSchoolmeester, M. and Locksley, R. M. and Else, K. J.},
  issn         = {1365-3024},
  keyword      = {Trichuris,mesenteric lymph nodes,large intestine,eosinophils,IL-4,muris},
  language     = {eng},
  number       = {1},
  pages        = {1--11},
  publisher    = {Wiley-Blackwell},
  series       = {Parasite Immunology},
  title        = {Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection},
  url          = {http://dx.doi.org/10.1111/j.1365-3024.2010.01246.x},
  volume       = {33},
  year         = {2011},
}