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The beta(1)-selective Adrenoceptor Agonist Dobutamine'': A Fallacy Being Perpetuated

Waldeck, Bertil LU (2011) 21st International Symposium on Chirality In Chirality 23(1). p.63-64
Abstract
Dobutamine is a cardiotonic agent, developed as a racemate more than 30 years ago. The compound soon got the label "the beta 1-selective adrenoceptor agonist''. However, a closer examination of the enantiomers showed that (+)-dobutamine is predominantly a beta(1)- and beta(2)-adrenoceptor agonist with modest selectivity whereas (-)-dobutamine is predominantly an alpha(1)-adrenoceptor agonist. Nevertheless, rac dobutamine is still frequently used as a tool for classification of beta-adrenoceptors. This ignorance of chiralilty may lead to erroneous conclusions and consolidate false labels. Chirality 23: 63-64, 2011. (C) 2010 Wiley-Liss, Inc.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
beta-adrenoceptors, alpha-adrenoceptors, dobutamine, enantiomers, selectivity
in
Chirality
volume
23
issue
1
pages
63 - 64
publisher
John Wiley & Sons
conference name
21st International Symposium on Chirality
external identifiers
  • wos:000285262400007
  • scopus:78650026307
ISSN
0899-0042
1520-636X
DOI
10.1002/chir.20874
language
English
LU publication?
yes
id
09dc56db-05d3-41bb-8f1e-9d44c17b8393 (old id 1774007)
date added to LUP
2011-02-01 10:07:40
date last changed
2017-07-30 03:20:58
@inproceedings{09dc56db-05d3-41bb-8f1e-9d44c17b8393,
  abstract     = {Dobutamine is a cardiotonic agent, developed as a racemate more than 30 years ago. The compound soon got the label "the beta 1-selective adrenoceptor agonist''. However, a closer examination of the enantiomers showed that (+)-dobutamine is predominantly a beta(1)- and beta(2)-adrenoceptor agonist with modest selectivity whereas (-)-dobutamine is predominantly an alpha(1)-adrenoceptor agonist. Nevertheless, rac dobutamine is still frequently used as a tool for classification of beta-adrenoceptors. This ignorance of chiralilty may lead to erroneous conclusions and consolidate false labels. Chirality 23: 63-64, 2011. (C) 2010 Wiley-Liss, Inc.},
  author       = {Waldeck, Bertil},
  booktitle    = {Chirality},
  issn         = {0899-0042},
  keyword      = {beta-adrenoceptors,alpha-adrenoceptors,dobutamine,enantiomers,selectivity},
  language     = {eng},
  number       = {1},
  pages        = {63--64},
  publisher    = {John Wiley & Sons},
  title        = {The beta(1)-selective Adrenoceptor Agonist Dobutamine'': A Fallacy Being Perpetuated},
  url          = {http://dx.doi.org/10.1002/chir.20874},
  volume       = {23},
  year         = {2011},
}