Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait
(2019) In Nature Communications 10(1).- Abstract
Survival to extreme ages clusters within families. However, identifying genetic loci conferring longevity and low morbidity in such longevous families is challenging. There is debate concerning the survival percentile that best isolates the genetic component in longevity. Here, we use three-generational mortality data from two large datasets, UPDB (US) and LINKS (Netherlands). We study 20,360 unselected families containing index persons, their parents, siblings, spouses, and children, comprising 314,819 individuals. Our analyses provide strong evidence that longevity is transmitted as a quantitative genetic trait among survivors up to the top 10% of their birth cohort. We subsequently show a survival advantage, mounting to 31%, for... (More)
Survival to extreme ages clusters within families. However, identifying genetic loci conferring longevity and low morbidity in such longevous families is challenging. There is debate concerning the survival percentile that best isolates the genetic component in longevity. Here, we use three-generational mortality data from two large datasets, UPDB (US) and LINKS (Netherlands). We study 20,360 unselected families containing index persons, their parents, siblings, spouses, and children, comprising 314,819 individuals. Our analyses provide strong evidence that longevity is transmitted as a quantitative genetic trait among survivors up to the top 10% of their birth cohort. We subsequently show a survival advantage, mounting to 31%, for individuals with top 10% surviving first and second-degree relatives in both databases and across generations, even in the presence of non-longevous parents. To guide future genetic studies, we suggest to base case selection on top 10% survivors of their birth cohort with equally long-lived family members.
(Less)
- author
- van den Berg, Niels ; Rodríguez-Girondo, Mar ; van Dijk, Ingrid K. LU ; Mourits, Rick J. ; Mandemakers, Kees ; Janssens, Angelique A.P.O. ; Beekman, Marian ; Smith, Ken R. and Slagboom, P. Eline
- publishing date
- 2019-01-07
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Communications
- volume
- 10
- issue
- 1
- article number
- 35
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:30617297
- scopus:85059813148
- ISSN
- 2041-1723
- DOI
- 10.1038/s41467-018-07925-0
- language
- English
- LU publication?
- no
- id
- 1774a3b8-afea-42a1-b98d-1cd479d79f48
- date added to LUP
- 2019-05-10 13:10:21
- date last changed
- 2024-04-16 04:55:49
@article{1774a3b8-afea-42a1-b98d-1cd479d79f48,
abstract = {{<p>Survival to extreme ages clusters within families. However, identifying genetic loci conferring longevity and low morbidity in such longevous families is challenging. There is debate concerning the survival percentile that best isolates the genetic component in longevity. Here, we use three-generational mortality data from two large datasets, UPDB (US) and LINKS (Netherlands). We study 20,360 unselected families containing index persons, their parents, siblings, spouses, and children, comprising 314,819 individuals. Our analyses provide strong evidence that longevity is transmitted as a quantitative genetic trait among survivors up to the top 10% of their birth cohort. We subsequently show a survival advantage, mounting to 31%, for individuals with top 10% surviving first and second-degree relatives in both databases and across generations, even in the presence of non-longevous parents. To guide future genetic studies, we suggest to base case selection on top 10% survivors of their birth cohort with equally long-lived family members.</p>}},
author = {{van den Berg, Niels and Rodríguez-Girondo, Mar and van Dijk, Ingrid K. and Mourits, Rick J. and Mandemakers, Kees and Janssens, Angelique A.P.O. and Beekman, Marian and Smith, Ken R. and Slagboom, P. Eline}},
issn = {{2041-1723}},
language = {{eng}},
month = {{01}},
number = {{1}},
publisher = {{Nature Publishing Group}},
series = {{Nature Communications}},
title = {{Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait}},
url = {{http://dx.doi.org/10.1038/s41467-018-07925-0}},
doi = {{10.1038/s41467-018-07925-0}},
volume = {{10}},
year = {{2019}},
}