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Influence of Insulin-Like Growth Factor-I and Nutrition during Phases of Postnatal Growth in Very Preterm Infants.

Pupp, Ingrid LU ; Löfqvist, Chatarina; Polberger, Staffan LU ; Niklasson, Aimon; Fellman, Vineta LU ; Hellström, Ann and Ley, David LU (2011) In Pediatric Research 69(5). p.448-453
Abstract
Pronounced growth restriction occurs after very preterm birth. The interaction between IGF-I, nutritional intake and growth was evaluated prospectively in 64 infants with a mean (SD) GA of 25.7 (1.9) weeks. Blood sampling of IGF-I and measurements of weight, length and head circumference were performed weekly until discharge. Daily calculation of nutritional intake. Standard deviation scores (SDS) for growth parameters defined two growth phases 1/growth restriction (GR) phase (birth until lowest SDS), 2/catch-up (CU) phase (lowest SDS until 35 gestational weeks). IGF-I concentrations during the first postnatal weeks were low, and increased at 30 weeks GA, irrespective of GA at birth, coinciding with initiation of CU growth. Concentrations... (More)
Pronounced growth restriction occurs after very preterm birth. The interaction between IGF-I, nutritional intake and growth was evaluated prospectively in 64 infants with a mean (SD) GA of 25.7 (1.9) weeks. Blood sampling of IGF-I and measurements of weight, length and head circumference were performed weekly until discharge. Daily calculation of nutritional intake. Standard deviation scores (SDS) for growth parameters defined two growth phases 1/growth restriction (GR) phase (birth until lowest SDS), 2/catch-up (CU) phase (lowest SDS until 35 gestational weeks). IGF-I concentrations during the first postnatal weeks were low, and increased at 30 weeks GA, irrespective of GA at birth, coinciding with initiation of CU growth. Concentrations of IGF-I were positively associated with change in weight SDS during the GR phase, p=0.001 and CU, p=0.004-0.027. Protein and energy intake were not associated with change in SDS weight during the GR phase as opposed to the CU phase (p<0.001 respectively). Nutritional intake did not correlate to concentrations of IGF-I before 30 weeks GA. IGF-I is associated with growth at an earlier postnatal age than nutrient intake and the effect of nutrition on levels of IGF-I may be restricted to the period of established CU growth. ABBREVIATIONS: (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Research
volume
69
issue
5
pages
448 - 453
publisher
International Pediatric Foundation Inc.
external identifiers
  • wos:000289811000014
  • pmid:21263374
  • scopus:79954572585
ISSN
1530-0447
DOI
10.1203/PDR.0b013e3182115000
language
English
LU publication?
yes
id
ed51dc58-0870-4e85-817c-cdb5f0e68840 (old id 1777072)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21263374?dopt=Abstract
date added to LUP
2011-02-01 09:18:26
date last changed
2017-11-19 03:08:45
@article{ed51dc58-0870-4e85-817c-cdb5f0e68840,
  abstract     = {Pronounced growth restriction occurs after very preterm birth. The interaction between IGF-I, nutritional intake and growth was evaluated prospectively in 64 infants with a mean (SD) GA of 25.7 (1.9) weeks. Blood sampling of IGF-I and measurements of weight, length and head circumference were performed weekly until discharge. Daily calculation of nutritional intake. Standard deviation scores (SDS) for growth parameters defined two growth phases 1/growth restriction (GR) phase (birth until lowest SDS), 2/catch-up (CU) phase (lowest SDS until 35 gestational weeks). IGF-I concentrations during the first postnatal weeks were low, and increased at 30 weeks GA, irrespective of GA at birth, coinciding with initiation of CU growth. Concentrations of IGF-I were positively associated with change in weight SDS during the GR phase, p=0.001 and CU, p=0.004-0.027. Protein and energy intake were not associated with change in SDS weight during the GR phase as opposed to the CU phase (p&lt;0.001 respectively). Nutritional intake did not correlate to concentrations of IGF-I before 30 weeks GA. IGF-I is associated with growth at an earlier postnatal age than nutrient intake and the effect of nutrition on levels of IGF-I may be restricted to the period of established CU growth. ABBREVIATIONS:},
  author       = {Pupp, Ingrid and Löfqvist, Chatarina and Polberger, Staffan and Niklasson, Aimon and Fellman, Vineta and Hellström, Ann and Ley, David},
  issn         = {1530-0447},
  language     = {eng},
  number       = {5},
  pages        = {448--453},
  publisher    = {International Pediatric Foundation Inc.},
  series       = {Pediatric Research},
  title        = {Influence of Insulin-Like Growth Factor-I and Nutrition during Phases of Postnatal Growth in Very Preterm Infants.},
  url          = {http://dx.doi.org/10.1203/PDR.0b013e3182115000},
  volume       = {69},
  year         = {2011},
}