Influence of Insulin-Like Growth Factor-I and Nutrition during Phases of Postnatal Growth in Very Preterm Infants.
(2011) In Pediatric Research 69(5). p.448-453- Abstract
- Pronounced growth restriction occurs after very preterm birth. The interaction between IGF-I, nutritional intake and growth was evaluated prospectively in 64 infants with a mean (SD) GA of 25.7 (1.9) weeks. Blood sampling of IGF-I and measurements of weight, length and head circumference were performed weekly until discharge. Daily calculation of nutritional intake. Standard deviation scores (SDS) for growth parameters defined two growth phases 1/growth restriction (GR) phase (birth until lowest SDS), 2/catch-up (CU) phase (lowest SDS until 35 gestational weeks). IGF-I concentrations during the first postnatal weeks were low, and increased at 30 weeks GA, irrespective of GA at birth, coinciding with initiation of CU growth. Concentrations... (More)
- Pronounced growth restriction occurs after very preterm birth. The interaction between IGF-I, nutritional intake and growth was evaluated prospectively in 64 infants with a mean (SD) GA of 25.7 (1.9) weeks. Blood sampling of IGF-I and measurements of weight, length and head circumference were performed weekly until discharge. Daily calculation of nutritional intake. Standard deviation scores (SDS) for growth parameters defined two growth phases 1/growth restriction (GR) phase (birth until lowest SDS), 2/catch-up (CU) phase (lowest SDS until 35 gestational weeks). IGF-I concentrations during the first postnatal weeks were low, and increased at 30 weeks GA, irrespective of GA at birth, coinciding with initiation of CU growth. Concentrations of IGF-I were positively associated with change in weight SDS during the GR phase, p=0.001 and CU, p=0.004-0.027. Protein and energy intake were not associated with change in SDS weight during the GR phase as opposed to the CU phase (p<0.001 respectively). Nutritional intake did not correlate to concentrations of IGF-I before 30 weeks GA. IGF-I is associated with growth at an earlier postnatal age than nutrient intake and the effect of nutrition on levels of IGF-I may be restricted to the period of established CU growth. ABBREVIATIONS: (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1777072
- author
- Pupp, Ingrid LU ; Löfqvist, Chatarina ; Polberger, Staffan LU ; Niklasson, Aimon ; Fellman, Vineta LU ; Hellström, Ann and Ley, David LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatric Research
- volume
- 69
- issue
- 5
- pages
- 448 - 453
- publisher
- International Pediatric Foundation Inc.
- external identifiers
-
- wos:000289811000014
- pmid:21263374
- scopus:79954572585
- pmid:21263374
- ISSN
- 1530-0447
- DOI
- 10.1203/PDR.0b013e3182115000
- language
- English
- LU publication?
- yes
- id
- ed51dc58-0870-4e85-817c-cdb5f0e68840 (old id 1777072)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21263374?dopt=Abstract
- date added to LUP
- 2016-04-01 10:17:40
- date last changed
- 2023-08-30 23:02:43
@article{ed51dc58-0870-4e85-817c-cdb5f0e68840, abstract = {{Pronounced growth restriction occurs after very preterm birth. The interaction between IGF-I, nutritional intake and growth was evaluated prospectively in 64 infants with a mean (SD) GA of 25.7 (1.9) weeks. Blood sampling of IGF-I and measurements of weight, length and head circumference were performed weekly until discharge. Daily calculation of nutritional intake. Standard deviation scores (SDS) for growth parameters defined two growth phases 1/growth restriction (GR) phase (birth until lowest SDS), 2/catch-up (CU) phase (lowest SDS until 35 gestational weeks). IGF-I concentrations during the first postnatal weeks were low, and increased at 30 weeks GA, irrespective of GA at birth, coinciding with initiation of CU growth. Concentrations of IGF-I were positively associated with change in weight SDS during the GR phase, p=0.001 and CU, p=0.004-0.027. Protein and energy intake were not associated with change in SDS weight during the GR phase as opposed to the CU phase (p<0.001 respectively). Nutritional intake did not correlate to concentrations of IGF-I before 30 weeks GA. IGF-I is associated with growth at an earlier postnatal age than nutrient intake and the effect of nutrition on levels of IGF-I may be restricted to the period of established CU growth. ABBREVIATIONS:}}, author = {{Pupp, Ingrid and Löfqvist, Chatarina and Polberger, Staffan and Niklasson, Aimon and Fellman, Vineta and Hellström, Ann and Ley, David}}, issn = {{1530-0447}}, language = {{eng}}, number = {{5}}, pages = {{448--453}}, publisher = {{International Pediatric Foundation Inc.}}, series = {{Pediatric Research}}, title = {{Influence of Insulin-Like Growth Factor-I and Nutrition during Phases of Postnatal Growth in Very Preterm Infants.}}, url = {{http://dx.doi.org/10.1203/PDR.0b013e3182115000}}, doi = {{10.1203/PDR.0b013e3182115000}}, volume = {{69}}, year = {{2011}}, }