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Mechanistic modelling of drug release from polymer-coated and swelling and dissolving polymer matrix systems.

Kaunisto, Erik LU ; Marucci, Mariagrazia LU ; Borgquist, Per LU and Axelsson, Anders LU (2011) In International Journal of Pharmaceutics 418. p.54-77
Abstract
The time required for the design of a new delivery device can be sensibly reduced if the release mechanism is understood and an appropriate mathematical model is used to characterize the system. Once all the model parameters are obtained, in silico experiments can be performed, to provide estimates of the release from devices with different geometries and compositions. In this review coated and matrix systems are considered. For coated formulations, models describing the diffusional drug release, the osmotic pumping drug release, and the lag phase of pellets undergoing cracking in the coating due to the build-up of a hydrostatic pressure are reviewed. For matrix systems, models describing pure polymer dissolution, diffusion in the polymer... (More)
The time required for the design of a new delivery device can be sensibly reduced if the release mechanism is understood and an appropriate mathematical model is used to characterize the system. Once all the model parameters are obtained, in silico experiments can be performed, to provide estimates of the release from devices with different geometries and compositions. In this review coated and matrix systems are considered. For coated formulations, models describing the diffusional drug release, the osmotic pumping drug release, and the lag phase of pellets undergoing cracking in the coating due to the build-up of a hydrostatic pressure are reviewed. For matrix systems, models describing pure polymer dissolution, diffusion in the polymer and drug release from swelling and eroding polymer matrix formulations are reviewed. Importantly, the experiments used to characterize the processes occurring during the release and to validate the models are presented and discussed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Pharmaceutics
volume
418
pages
54 - 77
publisher
Elsevier
external identifiers
  • wos:000296035400008
  • pmid:21256939
  • scopus:80052857200
ISSN
1873-3476
DOI
10.1016/j.ijpharm.2011.01.021
language
English
LU publication?
yes
id
d20871a3-85bf-4529-bc3f-74259d9e5ff6 (old id 1777122)
date added to LUP
2011-02-10 17:54:53
date last changed
2017-10-08 03:03:44
@article{d20871a3-85bf-4529-bc3f-74259d9e5ff6,
  abstract     = {The time required for the design of a new delivery device can be sensibly reduced if the release mechanism is understood and an appropriate mathematical model is used to characterize the system. Once all the model parameters are obtained, in silico experiments can be performed, to provide estimates of the release from devices with different geometries and compositions. In this review coated and matrix systems are considered. For coated formulations, models describing the diffusional drug release, the osmotic pumping drug release, and the lag phase of pellets undergoing cracking in the coating due to the build-up of a hydrostatic pressure are reviewed. For matrix systems, models describing pure polymer dissolution, diffusion in the polymer and drug release from swelling and eroding polymer matrix formulations are reviewed. Importantly, the experiments used to characterize the processes occurring during the release and to validate the models are presented and discussed.},
  author       = {Kaunisto, Erik and Marucci, Mariagrazia and Borgquist, Per and Axelsson, Anders},
  issn         = {1873-3476},
  language     = {eng},
  pages        = {54--77},
  publisher    = {Elsevier},
  series       = {International Journal of Pharmaceutics},
  title        = {Mechanistic modelling of drug release from polymer-coated and swelling and dissolving polymer matrix systems.},
  url          = {http://dx.doi.org/10.1016/j.ijpharm.2011.01.021},
  volume       = {418},
  year         = {2011},
}