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Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors

Thullberg, M; Bartkova, J; Khan, S; Hansen, Klaus; Rönnstrand, Lars LU ; Lukas, Jiri; Strauss, M and Bartek, Jiri (2000) In FEBS Letters 470(2). p.161-166
Abstract
p16(INK4a), p15(INK4b), p18(INK4c) and p19(INK4d) comprise a family of cyclin-dependent kinase inhibitors and tumor suppressors. We report that the INK4 proteins share the ability to arrest cells in G1, and interact with CDK4 or CDK6 with similar avidity. In contrast, only p18 and particularly p19 are phosphorylated in vivo, and each of the human INK4 proteins shows unique expression patterns dependent on cell and tissue type, and differentiation stage. Thus, the INK4 proteins harbor redundant as well as non-overlapping properties, suggesting distinct regulatory modes, and diverse roles for the individual INK4 family members in cell cycle control, cellular differentiation, and multistep oncogenesis.
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
FEBS Letters
volume
470
issue
2
pages
161 - 166
publisher
Wiley-Blackwell
external identifiers
  • scopus:0034708554
ISSN
1873-3468
language
English
LU publication?
no
id
b2a67523-154b-4110-b87d-d4d2c3cbaf13 (old id 1782575)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/10734227
http://www.sciencedirect.com/science/article/pii/S0014579300013077
date added to LUP
2013-05-14 16:07:31
date last changed
2017-02-05 04:38:06
@article{b2a67523-154b-4110-b87d-d4d2c3cbaf13,
  abstract     = {p16(INK4a), p15(INK4b), p18(INK4c) and p19(INK4d) comprise a family of cyclin-dependent kinase inhibitors and tumor suppressors. We report that the INK4 proteins share the ability to arrest cells in G1, and interact with CDK4 or CDK6 with similar avidity. In contrast, only p18 and particularly p19 are phosphorylated in vivo, and each of the human INK4 proteins shows unique expression patterns dependent on cell and tissue type, and differentiation stage. Thus, the INK4 proteins harbor redundant as well as non-overlapping properties, suggesting distinct regulatory modes, and diverse roles for the individual INK4 family members in cell cycle control, cellular differentiation, and multistep oncogenesis.},
  author       = {Thullberg, M and Bartkova, J and Khan, S and Hansen, Klaus and Rönnstrand, Lars and Lukas, Jiri and Strauss, M and Bartek, Jiri},
  issn         = {1873-3468},
  language     = {eng},
  number       = {2},
  pages        = {161--166},
  publisher    = {Wiley-Blackwell},
  series       = {FEBS Letters},
  title        = {Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors},
  volume       = {470},
  year         = {2000},
}