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TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia

Zainuddin, Norafiza; Murray, Fiona; Kanduri, Meena; Gunnarsson, Rebeqa LU ; Smedby, Karin E.; Enblad, Gunilla; Jurlander, Jesper; Juliusson, Gunnar LU and Rosenquist, Richard (2011) In Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis 35(2). p.272-274
Abstract
TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease... (More)
TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression. (C) 2010 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
TP53 mutation, 17p-deletion, Prognosis, Chronic lymphocytic leukemia
in
Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
volume
35
issue
2
pages
272 - 274
publisher
Elsevier
external identifiers
  • wos:000286460200024
  • scopus:78751702338
ISSN
1873-5835
DOI
10.1016/j.leukres.2010.08.023
language
English
LU publication?
yes
id
607dac1d-fa58-4df6-a17f-eca7532d14dc (old id 1790700)
date added to LUP
2011-03-02 13:17:51
date last changed
2017-05-14 03:02:44
@article{607dac1d-fa58-4df6-a17f-eca7532d14dc,
  abstract     = {TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression. (C) 2010 Elsevier Ltd. All rights reserved.},
  author       = {Zainuddin, Norafiza and Murray, Fiona and Kanduri, Meena and Gunnarsson, Rebeqa and Smedby, Karin E. and Enblad, Gunilla and Jurlander, Jesper and Juliusson, Gunnar and Rosenquist, Richard},
  issn         = {1873-5835},
  keyword      = {TP53 mutation,17p-deletion,Prognosis,Chronic lymphocytic leukemia},
  language     = {eng},
  number       = {2},
  pages        = {272--274},
  publisher    = {Elsevier},
  series       = {Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis},
  title        = {TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia},
  url          = {http://dx.doi.org/10.1016/j.leukres.2010.08.023},
  volume       = {35},
  year         = {2011},
}