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In vivo estimation of the contribution of elastin and collagen to the mechanical properties in the human abdominal aorta: effect of age and sex

Astrand, H.; Stalhand, J.; Karlsson, J.; Karlsson, M.; Sonesson, Björn LU and Lanne, T. (2011) In Journal of Applied Physiology 110(1). p.176-187
Abstract
Astrand H, Stalhand J, Karlsson J, Karlsson M, Sonesson B, Lanne T. In vivo estimation of the contribution of elastin and collagen to the mechanical properties in the human abdominal aorta: effect of age and sex. J Appl Physiol 110: 176-187, 2011. First published November 11, 2010; doi:10.1152/japplphysiol.00579.2010.-The mechanical properties of the aorta affect cardiac function and are related to cardiovascular morbidity/mortality. This study was designed to evaluate the isotropic (mainly elastin, elastin(iso)) and anisotropic (mainly collagen, collagen(ani)) material parameters within the human aorta in vivo. Thirty healthy men and women in three different age categories (23-30, 41-54, and 67-72 yr) were included. A novel mechanical... (More)
Astrand H, Stalhand J, Karlsson J, Karlsson M, Sonesson B, Lanne T. In vivo estimation of the contribution of elastin and collagen to the mechanical properties in the human abdominal aorta: effect of age and sex. J Appl Physiol 110: 176-187, 2011. First published November 11, 2010; doi:10.1152/japplphysiol.00579.2010.-The mechanical properties of the aorta affect cardiac function and are related to cardiovascular morbidity/mortality. This study was designed to evaluate the isotropic (mainly elastin, elastin(iso)) and anisotropic (mainly collagen, collagen(ani)) material parameters within the human aorta in vivo. Thirty healthy men and women in three different age categories (23-30, 41-54, and 67-72 yr) were included. A novel mechanical model was used to identify the mechanical properties and the strain field with aid of simultaneously recorded pressure and radius in the abdominal aorta. The magnitudes of the material parameters relating to both the stiffness of elastin(iso) and collagen(ani) were in agreement with earlier in vitro studies. The load-bearing fraction attributed to collagen(ani) oscillated from 10 to 30% between diastolic and systolic pressures during the cardiac cycle. With age, stiffness of elastin(iso) increased in men, despite the decrease in elastin content that has been found due to elastolysis. Furthermore, an increase in stiffness of collagen(ani) at high physiological pressure was found. This might be due to increased glycation, as well as changed isoforms of collagen in the aortic wall with age. A marked sex difference was observed, with a much less age-related effect, both on elastin(iso) and collagen(ani) stiffness in women. Possible factors of importance could be the effect of sex hormones, as well as differing collagen isoforms, between the sexes. (Less)
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organization
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Contribution to journal
publication status
published
subject
keywords
human, stiffness, artery, stress, strain
in
Journal of Applied Physiology
volume
110
issue
1
pages
176 - 187
publisher
American Physiological Society
external identifiers
  • wos:000286140900022
  • scopus:79251519000
ISSN
1522-1601
DOI
10.1152/japplphysiol.00579.2010
language
English
LU publication?
yes
id
8af358b7-6afb-46d4-b3cf-e1c6fb2d552c (old id 1790733)
date added to LUP
2011-03-02 13:15:40
date last changed
2017-11-12 03:17:30
@article{8af358b7-6afb-46d4-b3cf-e1c6fb2d552c,
  abstract     = {Astrand H, Stalhand J, Karlsson J, Karlsson M, Sonesson B, Lanne T. In vivo estimation of the contribution of elastin and collagen to the mechanical properties in the human abdominal aorta: effect of age and sex. J Appl Physiol 110: 176-187, 2011. First published November 11, 2010; doi:10.1152/japplphysiol.00579.2010.-The mechanical properties of the aorta affect cardiac function and are related to cardiovascular morbidity/mortality. This study was designed to evaluate the isotropic (mainly elastin, elastin(iso)) and anisotropic (mainly collagen, collagen(ani)) material parameters within the human aorta in vivo. Thirty healthy men and women in three different age categories (23-30, 41-54, and 67-72 yr) were included. A novel mechanical model was used to identify the mechanical properties and the strain field with aid of simultaneously recorded pressure and radius in the abdominal aorta. The magnitudes of the material parameters relating to both the stiffness of elastin(iso) and collagen(ani) were in agreement with earlier in vitro studies. The load-bearing fraction attributed to collagen(ani) oscillated from 10 to 30% between diastolic and systolic pressures during the cardiac cycle. With age, stiffness of elastin(iso) increased in men, despite the decrease in elastin content that has been found due to elastolysis. Furthermore, an increase in stiffness of collagen(ani) at high physiological pressure was found. This might be due to increased glycation, as well as changed isoforms of collagen in the aortic wall with age. A marked sex difference was observed, with a much less age-related effect, both on elastin(iso) and collagen(ani) stiffness in women. Possible factors of importance could be the effect of sex hormones, as well as differing collagen isoforms, between the sexes.},
  author       = {Astrand, H. and Stalhand, J. and Karlsson, J. and Karlsson, M. and Sonesson, Björn and Lanne, T.},
  issn         = {1522-1601},
  keyword      = {human,stiffness,artery,stress,strain},
  language     = {eng},
  number       = {1},
  pages        = {176--187},
  publisher    = {American Physiological Society},
  series       = {Journal of Applied Physiology},
  title        = {In vivo estimation of the contribution of elastin and collagen to the mechanical properties in the human abdominal aorta: effect of age and sex},
  url          = {http://dx.doi.org/10.1152/japplphysiol.00579.2010},
  volume       = {110},
  year         = {2011},
}