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Ultrasonographic findings in spontaneous miscarriage: relation to euploidy and aneuploidy

Ljunger, Elisabeth; Stavreus-Evers, Anneli; Cnattingius, Sven; Ekbom, Anders; Lundin, Catarina LU ; Anneren, Goran and Sundstrom-Poromaa, Inger (2011) In Fertility and Sterility 95(1). p.221-224
Abstract
Objective: To evaluate a possible correlation between transvaginal ultrasound findings in miscarriages and cytogenetic analyses from chorionic villi obtained by dilatation and curettage. Design: Prospective, population-based study. Setting: University-based hospital. Patient(s): Five hundred seventy-six women with spontaneous miscarriage diagnosed between 6 and 12 completed pregnancy weeks. Intervention(s): Transvaginal ultrasonography and dilatation and curettage. Main Outcome Measure(s): Cytogenetic analyses and ultrasound measurement of embryonic pole. Result(s): The mean gestational age was 9.5 weeks. Chromosomal analyses were successful in 259 cases, 159 with cytogenetic abnormalities and 100 euploidy. Empty gestational sacs were... (More)
Objective: To evaluate a possible correlation between transvaginal ultrasound findings in miscarriages and cytogenetic analyses from chorionic villi obtained by dilatation and curettage. Design: Prospective, population-based study. Setting: University-based hospital. Patient(s): Five hundred seventy-six women with spontaneous miscarriage diagnosed between 6 and 12 completed pregnancy weeks. Intervention(s): Transvaginal ultrasonography and dilatation and curettage. Main Outcome Measure(s): Cytogenetic analyses and ultrasound measurement of embryonic pole. Result(s): The mean gestational age was 9.5 weeks. Chromosomal analyses were successful in 259 cases, 159 with cytogenetic abnormalities and 100 euploidy. Empty gestational sacs were equally often found in euploidy and aneuploidy, whereas small embryonic or fetal poles were significantly more often associated with aneuploidy. Conclusion(s): A smaller than expected fetal size when a miscarriage is diagnosed during the first trimester is significantly associated with a chromosomal aberration. (Fertil Steril(R) 2011;95:221-4. (C) 2011 by American Society for Reproductive Medicine.) (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Miscarriage, karyotype, ultrasonography
in
Fertility and Sterility
volume
95
issue
1
pages
221 - 224
publisher
Elsevier
external identifiers
  • wos:000285411600045
  • scopus:78650414592
ISSN
1556-5653
DOI
10.1016/j.fertnstert.2010.06.018
language
English
LU publication?
yes
id
631360fe-3387-494d-90a5-7584e413b6c4 (old id 1790789)
date added to LUP
2011-03-02 13:08:37
date last changed
2017-08-13 03:10:46
@article{631360fe-3387-494d-90a5-7584e413b6c4,
  abstract     = {Objective: To evaluate a possible correlation between transvaginal ultrasound findings in miscarriages and cytogenetic analyses from chorionic villi obtained by dilatation and curettage. Design: Prospective, population-based study. Setting: University-based hospital. Patient(s): Five hundred seventy-six women with spontaneous miscarriage diagnosed between 6 and 12 completed pregnancy weeks. Intervention(s): Transvaginal ultrasonography and dilatation and curettage. Main Outcome Measure(s): Cytogenetic analyses and ultrasound measurement of embryonic pole. Result(s): The mean gestational age was 9.5 weeks. Chromosomal analyses were successful in 259 cases, 159 with cytogenetic abnormalities and 100 euploidy. Empty gestational sacs were equally often found in euploidy and aneuploidy, whereas small embryonic or fetal poles were significantly more often associated with aneuploidy. Conclusion(s): A smaller than expected fetal size when a miscarriage is diagnosed during the first trimester is significantly associated with a chromosomal aberration. (Fertil Steril(R) 2011;95:221-4. (C) 2011 by American Society for Reproductive Medicine.)},
  author       = {Ljunger, Elisabeth and Stavreus-Evers, Anneli and Cnattingius, Sven and Ekbom, Anders and Lundin, Catarina and Anneren, Goran and Sundstrom-Poromaa, Inger},
  issn         = {1556-5653},
  keyword      = {Miscarriage,karyotype,ultrasonography},
  language     = {eng},
  number       = {1},
  pages        = {221--224},
  publisher    = {Elsevier},
  series       = {Fertility and Sterility},
  title        = {Ultrasonographic findings in spontaneous miscarriage: relation to euploidy and aneuploidy},
  url          = {http://dx.doi.org/10.1016/j.fertnstert.2010.06.018},
  volume       = {95},
  year         = {2011},
}