Advanced

LifeGene-a large prospective population-based study of global relevance

Almqvist, Catarina; Adami, Hans-Olov; Franks, Paul LU ; Groop, Leif LU ; Ingelsson, Erik; Kere, Juha; Lissner, Lauren; Litton, Jan-Eric; Maeurer, Markus and Michaelsson, Karl, et al. (2011) In European Journal of Epidemiology 26(1). p.67-77
Abstract
Studying gene-environment interactions requires that the amount and quality of the lifestyle data is comparable to what is available for the corresponding genomic data. Sweden has several crucial prerequisites for comprehensive longitudinal biomedical research, such as the personal identity number, the universally available national health care system, continuously updated population and health registries and a scientifically motivated population. LifeGene builds on these strengths to bridge the gap between basic research and clinical applications with particular attention to populations, through a unique design in a research-friendly setting. LifeGene is designed both as a prospective cohort study and an infrastructure with repeated... (More)
Studying gene-environment interactions requires that the amount and quality of the lifestyle data is comparable to what is available for the corresponding genomic data. Sweden has several crucial prerequisites for comprehensive longitudinal biomedical research, such as the personal identity number, the universally available national health care system, continuously updated population and health registries and a scientifically motivated population. LifeGene builds on these strengths to bridge the gap between basic research and clinical applications with particular attention to populations, through a unique design in a research-friendly setting. LifeGene is designed both as a prospective cohort study and an infrastructure with repeated contacts of study participants approximately every 5 years. Index persons aged 18-45 years old will be recruited and invited to include their household members (partner and any children). A comprehensive questionnaire addressing cutting-edge research questions will be administered through the web with short follow-ups annually. Biosamples and physical measurements will also be collected at baseline, and re-administered every 5 years thereafter. Event-based sampling will be a key feature of LifeGene. The household-based design will give the opportunity to involve young couples prior to and during pregnancy, allowing for the first study of children born into cohort with complete pre-and perinatal data from both the mother and father. Questions and sampling schemes will be tailored to the participants' age and life events. The target of LifeGene is to enrol 500,000 Swedes and follow them longitudinally for at least 20 years. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biobank, Cohort study, Epidemiology, Prospective study, Questionnaires, Population genetics
in
European Journal of Epidemiology
volume
26
issue
1
pages
67 - 77
publisher
Springer
external identifiers
  • wos:000286104700009
  • scopus:79151483327
ISSN
1573-7284
DOI
10.1007/s10654-010-9521-x
language
English
LU publication?
yes
id
3709d5ef-b77f-4950-836a-19d3a094e24a (old id 1790914)
date added to LUP
2011-03-02 13:29:54
date last changed
2017-10-08 03:23:28
@article{3709d5ef-b77f-4950-836a-19d3a094e24a,
  abstract     = {Studying gene-environment interactions requires that the amount and quality of the lifestyle data is comparable to what is available for the corresponding genomic data. Sweden has several crucial prerequisites for comprehensive longitudinal biomedical research, such as the personal identity number, the universally available national health care system, continuously updated population and health registries and a scientifically motivated population. LifeGene builds on these strengths to bridge the gap between basic research and clinical applications with particular attention to populations, through a unique design in a research-friendly setting. LifeGene is designed both as a prospective cohort study and an infrastructure with repeated contacts of study participants approximately every 5 years. Index persons aged 18-45 years old will be recruited and invited to include their household members (partner and any children). A comprehensive questionnaire addressing cutting-edge research questions will be administered through the web with short follow-ups annually. Biosamples and physical measurements will also be collected at baseline, and re-administered every 5 years thereafter. Event-based sampling will be a key feature of LifeGene. The household-based design will give the opportunity to involve young couples prior to and during pregnancy, allowing for the first study of children born into cohort with complete pre-and perinatal data from both the mother and father. Questions and sampling schemes will be tailored to the participants' age and life events. The target of LifeGene is to enrol 500,000 Swedes and follow them longitudinally for at least 20 years.},
  author       = {Almqvist, Catarina and Adami, Hans-Olov and Franks, Paul and Groop, Leif and Ingelsson, Erik and Kere, Juha and Lissner, Lauren and Litton, Jan-Eric and Maeurer, Markus and Michaelsson, Karl and Palmgren, Juni and Pershagen, Goran and Ploner, Alexander and Sullivan, Patrick F. and Tybring, Gunnel and Pedersen, Nancy L.},
  issn         = {1573-7284},
  keyword      = {Biobank,Cohort study,Epidemiology,Prospective study,Questionnaires,Population genetics},
  language     = {eng},
  number       = {1},
  pages        = {67--77},
  publisher    = {Springer},
  series       = {European Journal of Epidemiology},
  title        = {LifeGene-a large prospective population-based study of global relevance},
  url          = {http://dx.doi.org/10.1007/s10654-010-9521-x},
  volume       = {26},
  year         = {2011},
}