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Tumor‐associated humoral cytotoxicity in patients with acute myelogenous leukemia before and after chemotherapy

Fäldt, R. LU and Ankerst, J. LU orcid (1977) In International Journal of Cancer 20(6). p.824-833
Abstract

Sera of eight unselected adult patients with acute myelogenous leukemia obtained before and after chemotherapy were repeatedly tested for specific complement‐dependent cytotoxicity against autochthonous peripheral white blood cells from the acute leukemia stage and from the remission stage, respectively. Complement‐dependent cytotoxicity against white blood cells from the acute leukemia stage was demonstrated in all of the eight patients, while none of three patients' sera were reactive against white blood cells from the remission stage tested in parallel. The cytotoxicity was increased after chemotherapy, also in those patients in whom remission was not achieved.

Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
20
issue
6
pages
824 - 833
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:271142
  • scopus:0017658222
ISSN
0020-7136
DOI
10.1002/ijc.2910200603
language
English
LU publication?
yes
id
1827481f-bf99-440f-b4a3-207a0da9fdf8
date added to LUP
2021-01-22 12:21:48
date last changed
2024-01-03 05:36:54
@article{1827481f-bf99-440f-b4a3-207a0da9fdf8,
  abstract     = {{<p>Sera of eight unselected adult patients with acute myelogenous leukemia obtained before and after chemotherapy were repeatedly tested for specific complement‐dependent cytotoxicity against autochthonous peripheral white blood cells from the acute leukemia stage and from the remission stage, respectively. Complement‐dependent cytotoxicity against white blood cells from the acute leukemia stage was demonstrated in all of the eight patients, while none of three patients' sera were reactive against white blood cells from the remission stage tested in parallel. The cytotoxicity was increased after chemotherapy, also in those patients in whom remission was not achieved.</p>}},
  author       = {{Fäldt, R. and Ankerst, J.}},
  issn         = {{0020-7136}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{824--833}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Tumor‐associated humoral cytotoxicity in patients with acute myelogenous leukemia before and after chemotherapy}},
  url          = {{http://dx.doi.org/10.1002/ijc.2910200603}},
  doi          = {{10.1002/ijc.2910200603}},
  volume       = {{20}},
  year         = {{1977}},
}