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Risk of recurrence following delayed large flap reconstruction after mastectomy for breast cancer.

Isern, A E; Manjer, Jonas LU ; Malina, J; Loman, Niklas LU ; Mårtensson, Tuve; Bofin, A; Hagen, A I; Tengrup, Ingrid; Landberg, Göran LU and Ringberg, Anita LU (2011) In British Journal of Surgery 98. p.659-666
Abstract
BACKGROUND: The aim of this retrospective matched cohort study was to evaluate the rate of recurrence among women with delayed large flap breast reconstruction after mastectomy for breast cancer. The recurrence rate among women treated at a single hospital was compared with that in an individually matched control group of women with breast cancer who did not have reconstruction after mastectomy. METHODS: Between 1982 and 2001, 125 women with previous invasive breast carcinoma underwent delayed large flap breast reconstruction with pedicled musculocutaneous or microvascular flaps (a median of 32 months after mastectomy). They were matched individually with 182 women with breast cancer who had a mastectomy but did not undergo breast... (More)
BACKGROUND: The aim of this retrospective matched cohort study was to evaluate the rate of recurrence among women with delayed large flap breast reconstruction after mastectomy for breast cancer. The recurrence rate among women treated at a single hospital was compared with that in an individually matched control group of women with breast cancer who did not have reconstruction after mastectomy. METHODS: Between 1982 and 2001, 125 women with previous invasive breast carcinoma underwent delayed large flap breast reconstruction with pedicled musculocutaneous or microvascular flaps (a median of 32 months after mastectomy). They were matched individually with 182 women with breast cancer who had a mastectomy but did not undergo breast reconstruction. Matching criteria were year of diagnosis, age at diagnosis and treating hospital. Medical records were evaluated until October 2007. Histopathological specimens for all included women were re-evaluated. The endpoint was locoregional or distant breast cancer recurrence. The risk of recurrent disease was calculated using a Cox proportional hazards analysis, adjusted for established prognostic factors. RESULTS: Median follow-up for the entire cohort was 146 months. The reconstruction group had a 2·08 (95 per cent confidence interval 1·07 to 4·06) times higher risk of recurrent disease than the mastectomy only group. CONCLUSION: Women with breast cancer who had delayed reconstruction with a large flap in this study had a higher risk of recurrent disease than those with mastectomy alone. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Surgery
volume
98
pages
659 - 666
publisher
John Wiley & Sons
external identifiers
  • wos:000289262900010
  • pmid:21312190
  • scopus:79953729631
ISSN
1365-2168
DOI
10.1002/bjs.7399
language
English
LU publication?
yes
id
446ec039-8248-4d84-9d69-161712ae7cdf (old id 1831951)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21312190?dopt=Abstract
date added to LUP
2011-03-01 14:22:38
date last changed
2017-11-12 04:08:00
@article{446ec039-8248-4d84-9d69-161712ae7cdf,
  abstract     = {BACKGROUND: The aim of this retrospective matched cohort study was to evaluate the rate of recurrence among women with delayed large flap breast reconstruction after mastectomy for breast cancer. The recurrence rate among women treated at a single hospital was compared with that in an individually matched control group of women with breast cancer who did not have reconstruction after mastectomy. METHODS: Between 1982 and 2001, 125 women with previous invasive breast carcinoma underwent delayed large flap breast reconstruction with pedicled musculocutaneous or microvascular flaps (a median of 32 months after mastectomy). They were matched individually with 182 women with breast cancer who had a mastectomy but did not undergo breast reconstruction. Matching criteria were year of diagnosis, age at diagnosis and treating hospital. Medical records were evaluated until October 2007. Histopathological specimens for all included women were re-evaluated. The endpoint was locoregional or distant breast cancer recurrence. The risk of recurrent disease was calculated using a Cox proportional hazards analysis, adjusted for established prognostic factors. RESULTS: Median follow-up for the entire cohort was 146 months. The reconstruction group had a 2·08 (95 per cent confidence interval 1·07 to 4·06) times higher risk of recurrent disease than the mastectomy only group. CONCLUSION: Women with breast cancer who had delayed reconstruction with a large flap in this study had a higher risk of recurrent disease than those with mastectomy alone. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.},
  author       = {Isern, A E and Manjer, Jonas and Malina, J and Loman, Niklas and Mårtensson, Tuve and Bofin, A and Hagen, A I and Tengrup, Ingrid and Landberg, Göran and Ringberg, Anita},
  issn         = {1365-2168},
  language     = {eng},
  pages        = {659--666},
  publisher    = {John Wiley & Sons},
  series       = {British Journal of Surgery},
  title        = {Risk of recurrence following delayed large flap reconstruction after mastectomy for breast cancer.},
  url          = {http://dx.doi.org/10.1002/bjs.7399},
  volume       = {98},
  year         = {2011},
}