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Anthropometric factors and ovarian cancer risk in the Malmö Diet and Cancer Study.

Brändstedt, Jenny LU ; Nodin, Björn LU ; Manjer, Jonas LU and Jirström, Karin LU (2011) In Cancer Epidemiology 35. p.432-437
Abstract
Objective: To examine the associations of measured anthropometric factors, including general and central adiposity, with epithelial ovarian cancer (EOC) risk in the Malmö Diet and Cancer Study. Methods: In 93 incident EOC cases from a Swedish population-based prospective cohort study, seven anthropometric factors; height, weight, BMI, body fat percentage, waist- and hip circumference, and waist-hip ratio (WHR), were categorized by tertiles of baseline anthropometric measurements and relative risks were calculated using multivariate Cox regression models. Results: A high WHR (<0.77, ≥0.77 to <0.81, ≥0.81cm/cm) was associated with a statistically significantly lower overall risk for EOC (RR 0.60; 0.36-1.00; p-trend=0.04), particularly... (More)
Objective: To examine the associations of measured anthropometric factors, including general and central adiposity, with epithelial ovarian cancer (EOC) risk in the Malmö Diet and Cancer Study. Methods: In 93 incident EOC cases from a Swedish population-based prospective cohort study, seven anthropometric factors; height, weight, BMI, body fat percentage, waist- and hip circumference, and waist-hip ratio (WHR), were categorized by tertiles of baseline anthropometric measurements and relative risks were calculated using multivariate Cox regression models. Results: A high WHR (<0.77, ≥0.77 to <0.81, ≥0.81cm/cm) was associated with a statistically significantly lower overall risk for EOC (RR 0.60; 0.36-1.00; p-trend=0.04), particularly tumours of differentiation grades 1 and 2 (RR 0.27; 0.09-0.81; p-trend=0.03) and clinical stages 1 and 2 (RR 0.32; 0.10-0.97; p-trend=0.03) and these associations were stronger in postmenopausal women. Neither height, weight, BMI, body fat percentage, waist- or hip circumference were associated with overall risk, nor with risk for different subtypes, differentiation grade or stage. Conclusions: These results demonstrate that a high WHR is associated with a decreased risk of EOC. Other anthropometric factors were not associated with EOC risk. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Epidemiology
volume
35
pages
432 - 437
publisher
Elsevier
external identifiers
  • wos:000296167600007
  • pmid:21288792
  • scopus:80052916321
ISSN
1877-7821
DOI
10.1016/j.canep.2011.01.003
language
English
LU publication?
yes
id
28f6cb89-c167-4fd0-aa56-67317ae93255 (old id 1832339)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21288792?dopt=Abstract
date added to LUP
2011-03-01 12:04:13
date last changed
2017-01-01 07:37:45
@article{28f6cb89-c167-4fd0-aa56-67317ae93255,
  abstract     = {Objective: To examine the associations of measured anthropometric factors, including general and central adiposity, with epithelial ovarian cancer (EOC) risk in the Malmö Diet and Cancer Study. Methods: In 93 incident EOC cases from a Swedish population-based prospective cohort study, seven anthropometric factors; height, weight, BMI, body fat percentage, waist- and hip circumference, and waist-hip ratio (WHR), were categorized by tertiles of baseline anthropometric measurements and relative risks were calculated using multivariate Cox regression models. Results: A high WHR (&lt;0.77, ≥0.77 to &lt;0.81, ≥0.81cm/cm) was associated with a statistically significantly lower overall risk for EOC (RR 0.60; 0.36-1.00; p-trend=0.04), particularly tumours of differentiation grades 1 and 2 (RR 0.27; 0.09-0.81; p-trend=0.03) and clinical stages 1 and 2 (RR 0.32; 0.10-0.97; p-trend=0.03) and these associations were stronger in postmenopausal women. Neither height, weight, BMI, body fat percentage, waist- or hip circumference were associated with overall risk, nor with risk for different subtypes, differentiation grade or stage. Conclusions: These results demonstrate that a high WHR is associated with a decreased risk of EOC. Other anthropometric factors were not associated with EOC risk.},
  author       = {Brändstedt, Jenny and Nodin, Björn and Manjer, Jonas and Jirström, Karin},
  issn         = {1877-7821},
  language     = {eng},
  pages        = {432--437},
  publisher    = {Elsevier},
  series       = {Cancer Epidemiology},
  title        = {Anthropometric factors and ovarian cancer risk in the Malmö Diet and Cancer Study.},
  url          = {http://dx.doi.org/10.1016/j.canep.2011.01.003},
  volume       = {35},
  year         = {2011},
}