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Children with screening-detected celiac disease show increased levels of nitric oxide products in urine.

Högberg, L; Webb, Charlotta LU ; Fälth-Magnusson, K; Forslund, T; Magnusson, K-E; Danielsson, L; Ivarsson, A; Karlsson, E; Sandström, O and Sundqvist, T (2011) In Acta paediatrica (Oslo, Norway : 1992) 100(7). p.1023-1027
Abstract
Aim Increased concentration of nitric oxide (NO) metabolites, nitrite and nitrate, in the urine is a strong indication of ongoing small intestinal, inflammation, which is a hallmark of the enteropathy of celiac disease (CD). It has previously been shown that children with symptomatic, untreated CD have increased levels of NO oxidation products in their urine. The aim of the present study was to investigate if screening-detected, asymptomatic celiac children display the same urinary nitrite/nitrate pattern. Methods In a multicenter screening study serum samples were collected from 7,207 12-year-old children without previously diagnosed CD. Sera were analyzed for anti-human tissue transglutaminase (tTG) of isotype IgA. Small bowel biopsy was... (More)
Aim Increased concentration of nitric oxide (NO) metabolites, nitrite and nitrate, in the urine is a strong indication of ongoing small intestinal, inflammation, which is a hallmark of the enteropathy of celiac disease (CD). It has previously been shown that children with symptomatic, untreated CD have increased levels of NO oxidation products in their urine. The aim of the present study was to investigate if screening-detected, asymptomatic celiac children display the same urinary nitrite/nitrate pattern. Methods In a multicenter screening study serum samples were collected from 7,207 12-year-old children without previously diagnosed CD. Sera were analyzed for anti-human tissue transglutaminase (tTG) of isotype IgA. Small bowel biopsy was performed in antibody-positive children, yielding 153 new cases of CD. In the screening detected individuals the sum of nitrite and nitrate concentrations in the urine was analyzed and used as an indicator of NO production. For comparison 73 children with untreated, symptomatic CD were studied. Results The nitrite/nitrate levels in children with screening-detected CD and those with untreated symptomatic CD did not differ significantly. Both groups had significantly increased urinary nitrite/nitrate concentrations compared to the children with normal small bowel biopsy (p<0.001). Conclusion Children with screening-detected CD have increased production of NO just as children with untreated symptomatic CD. High NO metabolite levels in the urine may indicate a pathogenetic feature of CD and be a marker of major clinical importance. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Nitric oxide, Coeliac disease, Screening, Urinary nitrite, nitrate
in
Acta paediatrica (Oslo, Norway : 1992)
volume
100
issue
7
pages
1023 - 1027
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000291224200031
  • pmid:21284717
  • scopus:79958034089
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2011.02186.x
language
English
LU publication?
yes
id
cbd5ff97-3a75-4545-a025-c5310789e1fc (old id 1832394)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21284717?dopt=Abstract
date added to LUP
2011-03-01 11:42:08
date last changed
2017-08-27 04:35:39
@article{cbd5ff97-3a75-4545-a025-c5310789e1fc,
  abstract     = {Aim Increased concentration of nitric oxide (NO) metabolites, nitrite and nitrate, in the urine is a strong indication of ongoing small intestinal, inflammation, which is a hallmark of the enteropathy of celiac disease (CD). It has previously been shown that children with symptomatic, untreated CD have increased levels of NO oxidation products in their urine. The aim of the present study was to investigate if screening-detected, asymptomatic celiac children display the same urinary nitrite/nitrate pattern. Methods In a multicenter screening study serum samples were collected from 7,207 12-year-old children without previously diagnosed CD. Sera were analyzed for anti-human tissue transglutaminase (tTG) of isotype IgA. Small bowel biopsy was performed in antibody-positive children, yielding 153 new cases of CD. In the screening detected individuals the sum of nitrite and nitrate concentrations in the urine was analyzed and used as an indicator of NO production. For comparison 73 children with untreated, symptomatic CD were studied. Results The nitrite/nitrate levels in children with screening-detected CD and those with untreated symptomatic CD did not differ significantly. Both groups had significantly increased urinary nitrite/nitrate concentrations compared to the children with normal small bowel biopsy (p&lt;0.001). Conclusion Children with screening-detected CD have increased production of NO just as children with untreated symptomatic CD. High NO metabolite levels in the urine may indicate a pathogenetic feature of CD and be a marker of major clinical importance.},
  author       = {Högberg, L and Webb, Charlotta and Fälth-Magnusson, K and Forslund, T and Magnusson, K-E and Danielsson, L and Ivarsson, A and Karlsson, E and Sandström, O and Sundqvist, T},
  issn         = {1651-2227},
  keyword      = {Nitric oxide,Coeliac disease,Screening,Urinary nitrite,nitrate},
  language     = {eng},
  number       = {7},
  pages        = {1023--1027},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta paediatrica (Oslo, Norway : 1992)},
  title        = {Children with screening-detected celiac disease show increased levels of nitric oxide products in urine.},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2011.02186.x},
  volume       = {100},
  year         = {2011},
}