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Growth-limiting role of endothelial cells in endoderm development.

Wolfhagen Sand, Fredrik LU ; Hörnblad, Andreas; Johansson, Jenny LU ; Lorén, Christina; Edsbagge, Josefina; Ståhlberg, Anders; Magenheim, Judith; Ilovich, Ohad; Mishani, Eyal and Dor, Yuval, et al. (2011) In Developmental Biology 352(2). p.267-277
Abstract
Endoderm development is dependent on inductive signals from different structures in close vicinity, including the notochord, lateral plate mesoderm and endothelial cells. Recently, we demonstrated that a functional vascular system is necessary for proper pancreas development, and that sphingosine-1-phosphate (S1P) exhibits the traits of a blood vessel-derived molecule involved in early pancreas morphogenesis. To examine whether S1P(1)-signaling plays a more general role in endoderm development, S1P(1)-deficient mice were analyzed. S1P(1) ablation results in compromised growth of several foregut-derived organs, including the stomach, dorsal and ventral pancreas and liver. Within the developing pancreas the reduction in organ size was due to... (More)
Endoderm development is dependent on inductive signals from different structures in close vicinity, including the notochord, lateral plate mesoderm and endothelial cells. Recently, we demonstrated that a functional vascular system is necessary for proper pancreas development, and that sphingosine-1-phosphate (S1P) exhibits the traits of a blood vessel-derived molecule involved in early pancreas morphogenesis. To examine whether S1P(1)-signaling plays a more general role in endoderm development, S1P(1)-deficient mice were analyzed. S1P(1) ablation results in compromised growth of several foregut-derived organs, including the stomach, dorsal and ventral pancreas and liver. Within the developing pancreas the reduction in organ size was due to deficient proliferation of Pdx1(+) pancreatic progenitors, whereas endocrine cell differentiation was unaffected. Ablation of endothelial cells in vitro did not mimic the S1P(1) phenotype, instead, increased organ size and hyperbranching were observed. Consistent with a negative role for endothelial cells in endoderm organ expansion, excessive vasculature was discovered in S1P(1)-deficient embryos. Altogether, our results show that endothelial cell hyperplasia negatively influences organ development in several foregut-derived organs. (Less)
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publication status
published
subject
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Developmental Biology
volume
352
issue
2
pages
267 - 277
publisher
Elsevier
external identifiers
  • wos:000289180200008
  • pmid:21281624
  • scopus:79953028801
ISSN
1095-564X
DOI
10.1016/j.ydbio.2011.01.026
language
English
LU publication?
yes
id
f0310917-4bca-4d09-819c-bef6d6f73b28 (old id 1832453)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21281624?dopt=Abstract
date added to LUP
2011-03-01 11:29:14
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2017-09-24 03:19:53
@article{f0310917-4bca-4d09-819c-bef6d6f73b28,
  abstract     = {Endoderm development is dependent on inductive signals from different structures in close vicinity, including the notochord, lateral plate mesoderm and endothelial cells. Recently, we demonstrated that a functional vascular system is necessary for proper pancreas development, and that sphingosine-1-phosphate (S1P) exhibits the traits of a blood vessel-derived molecule involved in early pancreas morphogenesis. To examine whether S1P(1)-signaling plays a more general role in endoderm development, S1P(1)-deficient mice were analyzed. S1P(1) ablation results in compromised growth of several foregut-derived organs, including the stomach, dorsal and ventral pancreas and liver. Within the developing pancreas the reduction in organ size was due to deficient proliferation of Pdx1(+) pancreatic progenitors, whereas endocrine cell differentiation was unaffected. Ablation of endothelial cells in vitro did not mimic the S1P(1) phenotype, instead, increased organ size and hyperbranching were observed. Consistent with a negative role for endothelial cells in endoderm organ expansion, excessive vasculature was discovered in S1P(1)-deficient embryos. Altogether, our results show that endothelial cell hyperplasia negatively influences organ development in several foregut-derived organs.},
  author       = {Wolfhagen Sand, Fredrik and Hörnblad, Andreas and Johansson, Jenny and Lorén, Christina and Edsbagge, Josefina and Ståhlberg, Anders and Magenheim, Judith and Ilovich, Ohad and Mishani, Eyal and Dor, Yuval and Ahlgren, Ulf and Semb, Henrik},
  issn         = {1095-564X},
  language     = {eng},
  number       = {2},
  pages        = {267--277},
  publisher    = {Elsevier},
  series       = {Developmental Biology},
  title        = {Growth-limiting role of endothelial cells in endoderm development.},
  url          = {http://dx.doi.org/10.1016/j.ydbio.2011.01.026},
  volume       = {352},
  year         = {2011},
}