Developmental changes in the rules for B cell selection*
Vergani, Stefano LU and Yuan, Joan LU
(2021)
In Immunological Reviews
300(1).
p.194-202
- Abstract
The autoimmune checkpoint during B cell maturation eliminates self-antigen reactive specificities from the mature B cell repertoire. However, an exception to this rule is illustrated by B-1 cells, an innate-like self-reactive B cell subset that is positively selected into the mature B cell pool in a self-antigen-driven fashion. The mechanisms by which B-1 cells escape central tolerance have puzzled the field for decades. A key clue comes from their restricted developmental window during fetal and neonatal life. Here we use B-1 cells as a prototypic early life derived B cell subset to explore developmental changes in the constraints of B cell selection. We discuss recent advancements in the understanding of the molecular program,... (More)
The autoimmune checkpoint during B cell maturation eliminates self-antigen reactive specificities from the mature B cell repertoire. However, an exception to this rule is illustrated by B-1 cells, an innate-like self-reactive B cell subset that is positively selected into the mature B cell pool in a self-antigen-driven fashion. The mechanisms by which B-1 cells escape central tolerance have puzzled the field for decades. A key clue comes from their restricted developmental window during fetal and neonatal life. Here we use B-1 cells as a prototypic early life derived B cell subset to explore developmental changes in the constraints of B cell selection. We discuss recent advancements in the understanding of the molecular program, centered around the RNA binding protein Lin28b, that licenses self-reactive B-1 cell output during ontogeny. Finally, we speculate on the possible link between the unique rules of early life B cell tolerance and the establishment of B cell – microbial mutualism to propose an integrated model for how developmental and environmental cues come together to create a protective layer of B cell memory involved in neonatal immune imprinting.
(Less)
- author
- Vergani, Stefano
LU
and Yuan, Joan
LU
- organization
- publishing date
- 2021-01-26
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- B cell tolerance, B-1 cells, early life B cell memory, Lin28b, neonatal immune imprinting, window of opportunity
- in
- Immunological Reviews
- volume
- 300
- issue
- 1
- pages
- 194 - 202
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:33501672
- scopus:85099747891
- ISSN
- 0105-2896
- DOI
- 10.1111/imr.12949
- language
- English
- LU publication?
- yes
- id
- 18343f90-db35-41f6-8ba7-7f2e1d611937
- date added to LUP
- 2021-02-02 11:09:55
- date last changed
- 2024-09-19 15:49:13
@article{18343f90-db35-41f6-8ba7-7f2e1d611937,
abstract = {{<p>The autoimmune checkpoint during B cell maturation eliminates self-antigen reactive specificities from the mature B cell repertoire. However, an exception to this rule is illustrated by B-1 cells, an innate-like self-reactive B cell subset that is positively selected into the mature B cell pool in a self-antigen-driven fashion. The mechanisms by which B-1 cells escape central tolerance have puzzled the field for decades. A key clue comes from their restricted developmental window during fetal and neonatal life. Here we use B-1 cells as a prototypic early life derived B cell subset to explore developmental changes in the constraints of B cell selection. We discuss recent advancements in the understanding of the molecular program, centered around the RNA binding protein Lin28b, that licenses self-reactive B-1 cell output during ontogeny. Finally, we speculate on the possible link between the unique rules of early life B cell tolerance and the establishment of B cell – microbial mutualism to propose an integrated model for how developmental and environmental cues come together to create a protective layer of B cell memory involved in neonatal immune imprinting.</p>}},
author = {{Vergani, Stefano and Yuan, Joan}},
issn = {{0105-2896}},
keywords = {{B cell tolerance; B-1 cells; early life B cell memory; Lin28b; neonatal immune imprinting; window of opportunity}},
language = {{eng}},
month = {{01}},
number = {{1}},
pages = {{194--202}},
publisher = {{Wiley-Blackwell}},
series = {{Immunological Reviews}},
title = {{Developmental changes in the rules for B cell selection*}},
url = {{http://dx.doi.org/10.1111/imr.12949}},
doi = {{10.1111/imr.12949}},
volume = {{300}},
year = {{2021}},
}