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A Biphasic Pattern of Reproductive Hormones in Healthy Female Infants : The COPENHAGEN Minipuberty Study

Ljubicic, Marie L. ; Busch, Alexander S. ; Upners, Emmie N. ; Fischer, Margit B. ; Petersen, Jørgen H. ; Raket, Lars L. LU orcid ; Frederiksen, Hanne ; Johannsen, Trine H. ; Juul, Anders and Hagen, Casper P. (2022) In The Journal of clinical endocrinology and metabolism 107(9). p.2598-2605
Abstract

CONTEXT: Minipuberty, a period of a transient activation of the hypothalamic-pituitary-gonadal (HPG) axis in both sexes, enables evaluation of gonadal function in infants suspected of hypogonadism. However, female minipuberty remains poorly elucidated. OBJECTIVE: We aimed to establish continuous reference ranges for the most commonly used reproductive hormones and to evaluate the dynamics of the HPG axis in females aged 0 to 1 year. DESIGN: The COPENHAGEN Minipuberty Study (ClinicalTrials.gov ID: NCT02784184), a longitudinal, prospective cohort study. SETTING: Healthy infants from Copenhagen. PATIENTS OR OTHER PARTICIPANTS: A total of 98 healthy, term female infants followed with 6 examinations including venipuncture during the first... (More)

CONTEXT: Minipuberty, a period of a transient activation of the hypothalamic-pituitary-gonadal (HPG) axis in both sexes, enables evaluation of gonadal function in infants suspected of hypogonadism. However, female minipuberty remains poorly elucidated. OBJECTIVE: We aimed to establish continuous reference ranges for the most commonly used reproductive hormones and to evaluate the dynamics of the HPG axis in females aged 0 to 1 year. DESIGN: The COPENHAGEN Minipuberty Study (ClinicalTrials.gov ID: NCT02784184), a longitudinal, prospective cohort study. SETTING: Healthy infants from Copenhagen. PATIENTS OR OTHER PARTICIPANTS: A total of 98 healthy, term female infants followed with 6 examinations including venipuncture during the first year of life.None. MAIN OUTCOME MEASURE(S): Serum concentrations of LH, FSH, inhibin B, anti-Müllerian hormone (AMH), estrone (E1), estradiol (E2), and SHBG were quantified using highly sensitive methods in 266 serum samples. RESULTS: Reference ranges were established for LH, FSH, inhibin B, AMH, E1, E2, and SHBG. Two peaks were observed in normalized mean curves for all hormones. The first peaks were timed around postnatal days 15 to 27 followed by a general nadir for all hormones around days 58 to 92. The second peaks occurred around days 107 to 125 for inhibin B, AMH, E1, E2, and SHBG and days 164 to 165 for LH and FSH. CONCLUSIONS: We present age-related, continuous reference ranges of the most commonly used reproductive hormones and present novel data revealing a biphasic and prolonged female minipuberty. CLINICALTRIALS.GOV ID: NCT02784184.

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; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
female, HPG axis, hypothalamic-pituitary-gonadal axis, minipuberty, reference ranges, reproductive hormones
in
The Journal of clinical endocrinology and metabolism
volume
107
issue
9
pages
8 pages
publisher
Oxford University Press
external identifiers
  • pmid:35704034
  • scopus:85136910676
ISSN
1945-7197
DOI
10.1210/clinem/dgac363
language
English
LU publication?
yes
id
183c5e67-7454-460b-9c6d-45a9d37a0c37
date added to LUP
2022-10-25 15:42:42
date last changed
2024-04-18 08:17:44
@article{183c5e67-7454-460b-9c6d-45a9d37a0c37,
  abstract     = {{<p>CONTEXT: Minipuberty, a period of a transient activation of the hypothalamic-pituitary-gonadal (HPG) axis in both sexes, enables evaluation of gonadal function in infants suspected of hypogonadism. However, female minipuberty remains poorly elucidated. OBJECTIVE: We aimed to establish continuous reference ranges for the most commonly used reproductive hormones and to evaluate the dynamics of the HPG axis in females aged 0 to 1 year. DESIGN: The COPENHAGEN Minipuberty Study (ClinicalTrials.gov ID: NCT02784184), a longitudinal, prospective cohort study. SETTING: Healthy infants from Copenhagen. PATIENTS OR OTHER PARTICIPANTS: A total of 98 healthy, term female infants followed with 6 examinations including venipuncture during the first year of life.None. MAIN OUTCOME MEASURE(S): Serum concentrations of LH, FSH, inhibin B, anti-Müllerian hormone (AMH), estrone (E1), estradiol (E2), and SHBG were quantified using highly sensitive methods in 266 serum samples. RESULTS: Reference ranges were established for LH, FSH, inhibin B, AMH, E1, E2, and SHBG. Two peaks were observed in normalized mean curves for all hormones. The first peaks were timed around postnatal days 15 to 27 followed by a general nadir for all hormones around days 58 to 92. The second peaks occurred around days 107 to 125 for inhibin B, AMH, E1, E2, and SHBG and days 164 to 165 for LH and FSH. CONCLUSIONS: We present age-related, continuous reference ranges of the most commonly used reproductive hormones and present novel data revealing a biphasic and prolonged female minipuberty. CLINICALTRIALS.GOV ID: NCT02784184.</p>}},
  author       = {{Ljubicic, Marie L. and Busch, Alexander S. and Upners, Emmie N. and Fischer, Margit B. and Petersen, Jørgen H. and Raket, Lars L. and Frederiksen, Hanne and Johannsen, Trine H. and Juul, Anders and Hagen, Casper P.}},
  issn         = {{1945-7197}},
  keywords     = {{female; HPG axis; hypothalamic-pituitary-gonadal axis; minipuberty; reference ranges; reproductive hormones}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{2598--2605}},
  publisher    = {{Oxford University Press}},
  series       = {{The Journal of clinical endocrinology and metabolism}},
  title        = {{A Biphasic Pattern of Reproductive Hormones in Healthy Female Infants : The COPENHAGEN Minipuberty Study}},
  url          = {{http://dx.doi.org/10.1210/clinem/dgac363}},
  doi          = {{10.1210/clinem/dgac363}},
  volume       = {{107}},
  year         = {{2022}},
}